Patricia Murray
YOU?
Author Swipe
View article: Evaluating Labelling Efficiency of Commercial SPIONs in Mesenchymal Stem/Stromal Cells for Magnetic Particle Imaging Applications
Evaluating Labelling Efficiency of Commercial SPIONs in Mesenchymal Stem/Stromal Cells for Magnetic Particle Imaging Applications Open
Magnetic Particle Imaging (MPI) is a state-of-the-art, highly sensitive modality for non-invasive cell tracking. This study evaluated labelling efficiency, biocompatibility, intracellular localization, and MPI detection sensitivity of four…
View article: Indoxyl sulfate as a potential tubular function marker across kidney disease models
Indoxyl sulfate as a potential tubular function marker across kidney disease models Open
Plasma indoxyl sulfate (IS) and its clearance correlate better with tubular injury markers (Kim-1, NGAL) than filtration markers (GFR, creatinine) in chronic nephrectomy rats and chronic/acute ischemic injury (IRI) in mice. Mass spectromet…
View article: Modelling Glomerular Filtration using Multispectral Optoacoustic Tomography and a Novel Near-infrared Dye
Modelling Glomerular Filtration using Multispectral Optoacoustic Tomography and a Novel Near-infrared Dye Open
Kidney disease carries significant morbidity, mortality, and financial cost. Preclinical work exploring more accurate methods for assessing renal function is key for monitoring disease progression and the efficacy of future therapies. Meas…
View article: Kidney protection during surgery on the thoracoabdominal aorta: a systematic review
Kidney protection during surgery on the thoracoabdominal aorta: a systematic review Open
OBJECTIVES Acute kidney injury (AKI) is a common consequence of surgical repair of the thoraco-abdominal aorta (TAA). Perfusion techniques aim to facilitate renal protection through oxygenation or hypothermia. This systematic review assess…
View article: Kidney Protection During Surgery on the Thoracoabdominal Aorta: A Systematic Review
Kidney Protection During Surgery on the Thoracoabdominal Aorta: A Systematic Review Open
Background Acute kidney injury (AKI) is a common complication of surgery to repair the thoracoabdominal aorta, and is associated with risks of dialysis and early mortality. Renal ischaemia, initiated by clamping of the suprarenal aorta, is…
View article: An analysis of the UK’s commercial stem cell clinics
An analysis of the UK’s commercial stem cell clinics Open
Commercial stem cell clinics in the UK are offering therapies of unproven efficacy that have the potential to cause harm. Marketing information used to advertise the therapies is often misleading and prices can be extortionate. Most so-cal…
View article: Modification of nanodiamonds for fluorescence bioimaging
Modification of nanodiamonds for fluorescence bioimaging Open
Detonated and milled nanodiamonds are modified with a fluorescent perylene diimide. The resulting nanodiamonds show enhanced fluorescence, good biocompatibility & uptake by mesenchyml stromal cells, and high fluorescence imaging quality.
View article: Inside Cover
Inside Cover Open
Cells expressing firefly luciferase that were labelled with gold nanorods (GNRs) could be visualised with multispectral optoacoustic tomography (MSOT), whereas control cells did not generate an MSOT signal. The white line in the left image…
View article: Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro
Umbilical cord mesenchymal stromal cell-derived extracellular vesicles lack the potency to immunomodulate human monocyte-derived macrophages in vitro Open
Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a role for secreted factors, such as MSC-derived extracellular vesicles (EVs). MSCs a…
View article: Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung
Intravenous Administration of Human Umbilical Cord Mesenchymal Stromal Cells Leads to an Inflammatory Response in the Lung Open
Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in preclinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment in the lungs. The immunomodulatory …
View article: Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using deep-learning-based semantic segmentation in histology
Quantifying acute kidney injury in an Ischaemia-Reperfusion Injury mouse model using deep-learning-based semantic segmentation in histology Open
This study focuses on ischaemia-reperfusion injury (IRI) in kidneys, a cause of acute kidney injury (AKI) and end-stage kidney disease (ESKD). Traditional kidney damage assessment methods are semi-quantitative and subjective. This study ai…
View article: Multispectral optoacoustic tomography is more sensitive than micro‐computed tomography for tracking gold nanorod labelled mesenchymal stromal cells
Multispectral optoacoustic tomography is more sensitive than micro‐computed tomography for tracking gold nanorod labelled mesenchymal stromal cells Open
Tracking the fate of therapeutic cell types is important for assessing their safety and efficacy. Bioluminescence imaging (BLI) is an effective cell tracking technique, but poor spatial resolution means it has limited ability to precisely …
View article: Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach
Harmonised culture procedures minimise but do not eliminate mesenchymal stromal cell donor and tissue variability in a decentralised multicentre manufacturing approach Open
Background Mesenchymal stromal cells (MSCs), commonly sourced from adipose tissue, bone marrow and umbilical cord, have been widely used in many medical conditions due to their therapeutic potential. Yet, the still limited understanding of…
View article: Harmonised culture procedures minimise but not eliminate mesenchymal stromal cell donor and tissue variability in a decentralized multicentre manufacturing approach
Harmonised culture procedures minimise but not eliminate mesenchymal stromal cell donor and tissue variability in a decentralized multicentre manufacturing approach Open
Background : Mesenchymal stromal cells (MSCs), commonly sourced from adipose tissue, bone marrow and umbilical cord, have been widely used in many medical conditions due to their therapeutic potential. Yet, the still limited understanding …
View article: Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging
Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging Open
Tracking the biodistribution of cell therapies is crucial for understanding their safety and efficacy. Optical imaging techniques are particularly useful for tracking cells due to their clinical translatability and potential for intra-oper…
View article: Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system
Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system Open
Mesenchymal stromal cells (MSCs) are multipotent cells showing promise in pre-clinical studies and currently used in many clinical trials. The regenerative potential of MSCs is mediated, at least in part, by direct and indirect immunomodul…
View article: Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging
Near infrared conjugated polymer nanoparticles (CPN™) for tracking cells using fluorescence and optoacoustic imaging Open
Tracking the biodistribution of cell therapies is crucial for understanding their safety and efficacy.
View article: Data: Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system
Data: Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system Open
This data set includes all the raw data collected for the following article: "Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system".
View article: Data: Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system
Data: Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system Open
This data set includes all the raw data collected for the following article: "Fate of intravenously administered umbilical cord mesenchymal stromal cells and interactions with the host's immune system".
View article: Evaluation of Cytotoxicity and Bioimaging of Nitrogen-Vacancy Nanodiamonds
Evaluation of Cytotoxicity and Bioimaging of Nitrogen-Vacancy Nanodiamonds Open
Nanodiamonds, due to their chemical inertness and biocompatibility, have found extensive uses in drug delivery and biomedical applications. Fluorescent nanodiamonds with fluorescent properties generated by nitrogen-vacancy defects have bee…
View article: Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival
Extracellular Vesicles from Human Umbilical Cord-Derived MSCs Affect Vessel Formation In Vitro and Promote VEGFR2-Mediated Cell Survival Open
Mesenchymal stromal cell (MSC)-derived extracellular vesicles (EVs) have emerged as novel tools in regenerative medicine. Angiogenesis modulation is widely studied for the treatment of ischaemic diseases, wound healing, and tissue regenera…
View article: Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells
Optical Tissue Clearing to Study the Intra-Pulmonary Biodistribution of Intravenously Delivered Mesenchymal Stromal Cells and Their Interactions with Host Lung Cells Open
Mesenchymal stromal cells (MSCs) injected intravenously are trapped in the capillaries of the lungs and die within the first 24 h. Studying the biodistribution and fate of labelled therapeutic cells in the 3D pulmonary context is important…
View article: Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung
Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung Open
Mesenchymal stromal cells (MSCs) administered intravenously (IV) have shown efficacy in pre-clinical models of various diseases. This is despite the cells not reaching the site of injury due to entrapment in the lungs. The ability of MSCs …
View article: DATA: Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung
DATA: Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung Open
This data set includes all the raw data collected for the following article: "Intravenous administration of human umbilical cord mesenchymal stromal cells leads to an inflammatory response in the lung."
View article: Data: DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype
Data: DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype Open
This data set includes all the raw data collected for the following article: "DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation …
View article: Data: DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype
Data: DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation and phenotype Open
This data set includes all the raw data collected for the following article: "DEAE-Dextran enhances the lentiviral transduction of primary human mesenchymal stromal cells from all major tissue sources without affecting their proliferation …