Deborah A. Pearson
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View article: Characterizing developmental and behavioral profiles in developmental synaptopathies to inform clinical trial endpoints
Characterizing developmental and behavioral profiles in developmental synaptopathies to inform clinical trial endpoints Open
Background: The Developmental Synaptopathies Consortium is a multi-site natural history network studying rare, neurogenetic syndromes associated with synaptic dysfunction and developmental delays. One aim of the Consortium is clinical tria…
View article: P205: Investigating sex differences in the behavioral phenotypes of Phelan-McDermid syndrome, tuberous sclerosis complex, and PTEN hamartoma tumor syndrome
P205: Investigating sex differences in the behavioral phenotypes of Phelan-McDermid syndrome, tuberous sclerosis complex, and PTEN hamartoma tumor syndrome Open
View article: 56. Longitudinal Neurodevelopmental Outcomes In Patients Undergoing Surgical Correction Of Nonsyndromic Craniosynostosis In A Single Center: A Prospective Study
56. Longitudinal Neurodevelopmental Outcomes In Patients Undergoing Surgical Correction Of Nonsyndromic Craniosynostosis In A Single Center: A Prospective Study Open
View article: Parental Stress in Tuberous Sclerosis Complex
Parental Stress in Tuberous Sclerosis Complex Open
View article: Pancreatic Replacement Therapy for Maladaptive Behaviors in Preschool Children With Autism Spectrum Disorder
Pancreatic Replacement Therapy for Maladaptive Behaviors in Preschool Children With Autism Spectrum Disorder Open
Importance There is an urgent unmet need for a treatment addressing the core symptoms and associated maladaptive symptoms of autism spectrum disorder (ASD), especially in preschool populations. Objectives To evaluate whether treatment of c…
View article: Profile of Autism Spectrum Disorder in Tuberous Sclerosis Complex: Results from a Longitudinal, Prospective, Multisite Study
Profile of Autism Spectrum Disorder in Tuberous Sclerosis Complex: Results from a Longitudinal, Prospective, Multisite Study Open
Objective Tuberous sclerosis complex (TSC) is highly associated with autism spectrum disorder (ASD). Objectives of the study were to characterize autistic features in young children with TSC. Methods Participants included 138 children foll…
View article: ADHD severity as a predictor of cognitive task performance in children with Autism Spectrum Disorder (ASD)
ADHD severity as a predictor of cognitive task performance in children with Autism Spectrum Disorder (ASD) Open
View article: Epilepsy Risk Prediction Model for Patients With Tuberous Sclerosis Complex
Epilepsy Risk Prediction Model for Patients With Tuberous Sclerosis Complex Open
View article: Effects of Extended-Release Methylphenidate Treatment on Cognitive Task Performance in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder
Effects of Extended-Release Methylphenidate Treatment on Cognitive Task Performance in Children with Autism Spectrum Disorder and Attention-Deficit/Hyperactivity Disorder Open
Objective: To examine the effectiveness of four doses of psychostimulant medication, combining extended-release methylphenidate (ER-MPH) in the morning with immediate-release MPH (IR-MPH) in the afternoon, on cognitive task p…
View article: Two different genetic etiologies for tuberous sclerosis complex (TSC) in a single family
Two different genetic etiologies for tuberous sclerosis complex (TSC) in a single family Open
Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic condition that involves abnormalities of the skin, hamartomas in the heart, brain, and kidneys, seizures, as well as TSC‐associated neuropsychiatric disorders (TA…
View article: Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex
Pilot Study of Neurodevelopmental Impact of Early Epilepsy Surgery in Tuberous Sclerosis Complex Open
View article: Community resilience to seismic events : a case study of Haida Gwaii, Canada
Community resilience to seismic events : a case study of Haida Gwaii, Canada Open
Small, remote communities situated along the Pacific Northwest coast of British Columbia are vulnerable to seismic events including earthquakes, and near- and far-field tsunamis. These have the potential to affect community sustainability.…
View article: Stimulant Medications and Cognition, Behavior and Quality of Life in Children and Youth with HIV
Stimulant Medications and Cognition, Behavior and Quality of Life in Children and Youth with HIV Open
The results suggest expectations for behavioral improvement may not align well with long-term effects of stimulant prescription use on behavior and QOL in children with HIV. Further research is necessary to determine if there are subsets o…