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View article: Increasing uptake of physical health checks for people living with severe mental illness: a systematic review
Increasing uptake of physical health checks for people living with severe mental illness: a systematic review Open
Background People living with severe mental illness (SMI) can experience greater risk of premature mortality than the general population with preventable physical ill health a major contributor. Physical health checks are a strategy to imp…
View article: Revisiting the Links Between Asthma and the Psychosis Spectrum: shared molecular mechanisms
Revisiting the Links Between Asthma and the Psychosis Spectrum: shared molecular mechanisms Open
Epidemiological studies suggest associations of asthma with the psychosis spectrum (psychotic experiences, bipolar disorder, schizophrenia), but the mechanisms underlying these associations remain unclear. We examined the relationship betw…
View article: Predicting risk of psychosis in primary care: a qualitative study
Predicting risk of psychosis in primary care: a qualitative study Open
Background P Risk is a new tool that aims to help GPs identify people who are at risk of developing psychosis. It uses electronic health record data on non-psychotic symptoms, medications, and sociodemographic factors. Aim To explore clini…
View article: Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: evidence from a population-based birth cohort in the United Kingdom
Psychotic experiences and disorders in adolescents and young adults with borderline intellectual functioning and intellectual disabilities: evidence from a population-based birth cohort in the United Kingdom Open
Background Individuals with borderline intellectual functioning and intellectual disabilities (intellectual impairment) may be at increased risk of psychosis. However, studies have been limited by small and selected samples. Moreover, the …
View article: Efficacy and Safety of Adding 6 Weeks of Doxycycline to the Essential Package of Care to Treat Filarial Lymphedema: A Double-Blind, Randomized, Controlled Trial in Southern India
Efficacy and Safety of Adding 6 Weeks of Doxycycline to the Essential Package of Care to Treat Filarial Lymphedema: A Double-Blind, Randomized, Controlled Trial in Southern India Open
Finding additional ways to manage lymphedema due to lymphatic filariasis (LF) is a primary concern for the Global Program to Eliminate Lymphatic Filariasis. The WHO-recommended Essential Package of Care (EPC) consists of skin hygiene, elev…
View article: Effect of Adding a Six-Week Course of Doxycycline to Intensive Hygiene-Based Care for Improving Lymphedema in a Rural Setting of Mali: A Double-Blind, Randomized Controlled 24-Month Trial
Effect of Adding a Six-Week Course of Doxycycline to Intensive Hygiene-Based Care for Improving Lymphedema in a Rural Setting of Mali: A Double-Blind, Randomized Controlled 24-Month Trial Open
Lymphedema (LE) is one the most disfiguring chronic manifestations of lymphatic filariasis. Its management relies primarily on limb hygiene and local care. A previous study in Ghana demonstrating a beneficial effect of doxycycline on LE le…
View article: External validation of a prognostic model to improve prediction of psychosis: a retrospective cohort study in primary care
External validation of a prognostic model to improve prediction of psychosis: a retrospective cohort study in primary care Open
Background Early detection could reduce the duration of untreated psychosis. GPs are a vital part of the psychosis care pathway, but find it difficult to detect the early features. An accurate risk prediction tool, P Risk, was developed to…
View article: Psychotic experiences and disorders in adolescents and young adults with intellectual disabilities: Evidence from a population-based birth cohort in the United Kingdom
Psychotic experiences and disorders in adolescents and young adults with intellectual disabilities: Evidence from a population-based birth cohort in the United Kingdom Open
Summary Background Evidence suggests that individuals with intellectual disabilities may be at increased risk of affective and non-affective psychotic disorders. However, studies so far have been limited by small and selected samples. More…
View article: Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol
Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol Open
Background Early intervention in psychosis (EIP) services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority yo…
View article: PB0323 Preliminary Analysis of ATHN 16: Real-World Safety of Eptacog Beta
PB0323 Preliminary Analysis of ATHN 16: Real-World Safety of Eptacog Beta Open
Background: Congenital thrombotic thrombocytopenic purpura (cTTP) is an ultra-rare thrombotic disorder caused by an inherited deficiency of the von Willebrand factor-cleaving enzyme ADAMTS13.Aims: To synthesize knowledge on the disease bur…
View article: The potential of digital behavioural tests as a diagnostic aid for psychosis
The potential of digital behavioural tests as a diagnostic aid for psychosis Open
Timely interventions have a proven benefit for people experiencing psychotic illness. One bottleneck to accessing timely interventions is the referral process to the specialist team for early psychosis (STEP). Many general practitioners la…
View article: Antipsychotic Medication and Risk of Metabolic Disorders in People With Schizophrenia: A Longitudinal Study Using the UK Clinical Practice Research Datalink
Antipsychotic Medication and Risk of Metabolic Disorders in People With Schizophrenia: A Longitudinal Study Using the UK Clinical Practice Research Datalink Open
Background and Hypothesis Antipsychotics are first-line drug treatments for schizophrenia. When antipsychotic monotherapy is ineffective, combining two antipsychotic drugs is common although treatment guidelines warn of possible increases …
View article: Association between menopause and suicidal ideation in mothers of adolescents: A longitudinal study using data from a population-based cohort
Association between menopause and suicidal ideation in mothers of adolescents: A longitudinal study using data from a population-based cohort Open
Women who have experienced the onset of menopausal transition presented an increased risk of suicidal ideation. Psychosocial interventions to increase social support may be beneficial in preventing mental health inequalities during menopau…
View article: Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol (Preprint)
Implementing and Evaluating a National Integrated Digital Registry and Clinical Decision Support System in Early Intervention in Psychosis Services (Early Psychosis Informatics Into Care): Co-Designed Protocol (Preprint) Open
BACKGROUND Early intervention in psychosis (EIP) services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority y…
View article: Early Psychosis Informatics into Care [EPICare]: A co-designed protocol for implementing and evaluating a national integrated digital registry and clinical decision support system within early intervention in psychosis services
Early Psychosis Informatics into Care [EPICare]: A co-designed protocol for implementing and evaluating a national integrated digital registry and clinical decision support system within early intervention in psychosis services Open
Introduction Early Intervention in Psychosis services are nationally mandated in England to provide multidisciplinary care to people experiencing first-episode psychosis, which disproportionately affects deprived and ethnic minority youth.…
View article: Digital behavioural tests as diagnostic aid for psychosis
Digital behavioural tests as diagnostic aid for psychosis Open
Timely interventions have a proven benefit for people experiencing psychotic illness. One bottleneck to accessing timely interventions is the referral process to the specialist team for early psychosis (STEP). Many general practitioners la…
View article: Urban factors and mental health symptoms in children of the Tokyo Early Adolescence Survey; impact of proximity to railway stations
Urban factors and mental health symptoms in children of the Tokyo Early Adolescence Survey; impact of proximity to railway stations Open
There is an evolving literature on the association of the proximity of place of residence to specific urban features with mental health symptoms or diagnoses, although few studies have examined these associations in children. This study te…
View article: Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort
Childhood Trauma As a Mediator of the Association Between Autistic Traits and Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children Cohort Open
Background Little is known on whether associations between childhood autistic traits and psychotic experiences persist into adulthood and whether genetic confounding and childhood trauma influence them. Here we investigate the associations…
View article: Stakeholder perceptions of lethal means safety counseling: A qualitative systematic review
Stakeholder perceptions of lethal means safety counseling: A qualitative systematic review Open
Introduction Lethal means safety counseling (LMSC) is an evidence-based suicide prevention intervention during which providers encourage patients to limit their access to lethal means (e.g., firearms, medications). Despite agreement about …
View article: Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): outcomes and community-based validation
Emotion Recognition and the Screening Instrument for Borderline Personality Disorder (SI-Bord): outcomes and community-based validation Open
Background Borderline Personality Disorder (BPD) is a psychiatric condition characterized by impulsivity, affect instability, dysregulation, low self-image, and interpersonal difficulties. There are many instruments to measure traits of BP…
View article: Developing and internally validating a prognostic model (P Risk) to improve the prediction of psychosis in a primary care population using electronic health records: The MAPPED study
Developing and internally validating a prognostic model (P Risk) to improve the prediction of psychosis in a primary care population using electronic health records: The MAPPED study Open
NIHR, School for Primary Care Research, Biomedical Research Centre.
View article: Characteristics of suicide attempts associated with lethality and method: A latent class analysis of the Military Suicide Research Consortium
Characteristics of suicide attempts associated with lethality and method: A latent class analysis of the Military Suicide Research Consortium Open
While suicide prevention is a national priority, particularly among service members and veterans (SMVs), understanding of suicide-related outcomes remains poor. Person-centered approaches (e.g., latent class analysis) have promise to ident…
View article: Immunological pathways underlying autism: Findings from Mendelian randomization and genetic colocalisation analyses
Immunological pathways underlying autism: Findings from Mendelian randomization and genetic colocalisation analyses Open
Emerging evidence implicates the role of inflammation and immunity in autism. However, little is known about the involvement of specific immunological pathways and their causal role. In 18,381 autism cases and 27,969 controls from the PGC …
View article: Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood
Precursors and correlates of transient and persistent longitudinal profiles of psychotic experiences from late childhood through early adulthood Open
Background Psychotic experiences are reported by 5–10% of young people, although only a minority persist and develop into psychotic disorders. It is unclear what characteristics differentiate those with transient psychotic experiences from…
View article: The Impact of Professional Coaching on Emerging Leaders
The Impact of Professional Coaching on Emerging Leaders Open
Coaching is a well-established developmental tool for senior managers and leaders, but almost no research has examined the value of coaching for young, emerging leaders. This paper presents two studies examining the impact of leadership co…
View article: Childhood trauma as a mediator of the association between autistic traits and psychotic experiences: evidence from the ALSPAC birth cohort
Childhood trauma as a mediator of the association between autistic traits and psychotic experiences: evidence from the ALSPAC birth cohort Open
Introduction: There is increasing evidence that autistic traits are associated with psychotic experiences. However, the mechanisms underlying such associations are still unknown. In this longitudinal birth cohort study, we examine the rela…
View article: Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs
Parental inflammatory bowel disease and autism in the offspring: Triangulating the evidence using four complementary study designs Open
Importance Evidence linking parental diagnoses of inflammatory bowel disease (IBD) with offspring autism is inconclusive. Objective To investigate associations between parental diagnoses of IBD and offspring autism and elucidate their unde…
View article: The Association Between Locus of Control and Psychopathology: A Cross-Cohort Comparison Between a UK (Avon Longitudinal Study of Parents and Children) and a Japanese (Tokyo Teen Cohort) Cohort
The Association Between Locus of Control and Psychopathology: A Cross-Cohort Comparison Between a UK (Avon Longitudinal Study of Parents and Children) and a Japanese (Tokyo Teen Cohort) Cohort Open
Background: An external locus of control (externality) is associated with poorer psychopathology in individualist cultures, but associations are reported to be weaker in collectivist cultures where an external style is less maladaptive. We…