Anna S. Dotsenko
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The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme Open
An acidic shift in the pH profile of Clonostachys rosea zearalenone hydrolase (ZHD), the most effective and well-studied zearalenone-specific lactone hydrolase, is required to extend the range of applications for the enzyme as a decontamin…
Comparative Study of the Convertibility of Pretreated Miscanthus Straw Using Enzyme Preparations Produced by Different Recombinant Strains of Penicillium verruculosum Open
Non-edible cellulosic biomass from perennial herbaceous plants is a promising and abundant feedstock for replacing slow-growing woody plants used in biotechnological applications. Herbaceous plant biomass, as other types of plant biomass, …
Testing and improving the performance of protein thermostability predictors for the engineering of cellulases Open
Thermostability of cellulases can be increased through amino acid substitutions and by protein engineering with predictors of protein thermostability. We have carried out a systematic analysis of the performance of 18 predictors for the en…
Conserved Peptides Recognition by Ensemble of Neural Networks for Mining Protein Data – LPMO Case Study Open
Mining protein data is a recent promising area of modern bioinformatics. In this work, we suggested a novel approach for mining protein data – conserved peptides recognition by ensemble of neural networks (CPRENN). This approach was applie…
Magnetic resonance spectroscopy of hippocampal and striatal neurometabolites in experimental PTSD rat modeling Open
The spectrum of the metabolites in the dorsal region of the hippocampus and striatum was studied using the method of 1H magnetic resonance spectroscopy at experimental modeling of the posttraumatic stress disorder syndrome (PTSD) in rats. …
Effect of<i>N</i>-linked glycosylation on the activity and other properties of recombinant endoglucanase IIa (Cel5A) from<i>Penicillium verruculosum</i> Open
Endoglucanase IIa from Penicillium verruculosum (PvCel5A) has three potential N-glycosylation sites: Asn19, Asn42 and Asn194. In order to study the role of N-glycosylation, the wild type (wt) PvCel5A and its mutant forms, carrying Asn to A…