Artur Mazur
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View article: Synthesis of Antiviral Drug Tecovirimat and Its Key Maleimide Intermediates Using Organocatalytic Mumm Rearrangement at Ambient Conditions
Synthesis of Antiviral Drug Tecovirimat and Its Key Maleimide Intermediates Using Organocatalytic Mumm Rearrangement at Ambient Conditions Open
Tecovirimat is an antiviral agent approved for the treatment of orthopoxvirus infections including smallpox, cowpox and monkeypox. A key challenge in its synthesis lies in the generation of maleimide intermediates, which traditionally requ…
View article: Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier Open
Nuclear pore complexes (NPCs) mediate selective exchange of macromolecules between the nucleus and cytoplasm, but the organization of their transport barrier has been a matter of debate. Here we used high-speed atomic force microscopy, com…
View article: The Clinical and Diagnostic Characterization of 6q24-Related Transient Neonatal Diabetes Mellitus: A Polish Pediatric Cohort Study
The Clinical and Diagnostic Characterization of 6q24-Related Transient Neonatal Diabetes Mellitus: A Polish Pediatric Cohort Study Open
Background/Objectives: Transient neonatal diabetes mellitus (TNDM) is a form of neonatal diabetes mellitus (NDM) arising in the first weeks of life and remitting in infancy. Epigenetic aberrations at the imprinted 6q24 locus (overexpressio…
View article: Control and determinants of the tobacco epidemic and the use of other tobacco products among children and adolescents in the Subcarpathian Voivodeship
Control and determinants of the tobacco epidemic and the use of other tobacco products among children and adolescents in the Subcarpathian Voivodeship Open
Introduction Tobacco smoking remains one of the most significant public health challenges, particularly among children and adolescents, for whom early smoking initiation increases the risk of long-term addiction and severe health consequen…
View article: Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants
Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants Open
Importance Extremely preterm infants are at high risk for bronchopulmonary dysplasia (BPD) and death. Multiple small randomized clinical trials showed that a combination of budesonide with surfactant compared with surfactant alone reduced …
View article: Diagnostic value of cardiac magnetic resonance imaging during transition care in adolescents with Turner syndrome
Diagnostic value of cardiac magnetic resonance imaging during transition care in adolescents with Turner syndrome Open
Background Turner Syndrome (TS) is a chromosomal disorder frequently associated with congenital cardiovascular abnormalities, particularly bicuspid aortic valve (BAV), coarctation of the aorta (CoA), and aortic dilatation. These conditions…
View article: Body Modifications in Adolescents: Risks, Responsibilities, and the Role of Paediatricians
Body Modifications in Adolescents: Risks, Responsibilities, and the Role of Paediatricians Open
Aim This European Academy of Paediatrics (EAP) position paper provides a comprehensive overview of body modifications (BMs) among adolescents, addressing prevalence, health implications and regulatory gaps. Based on these findings, it offe…
View article: Delayed Intervention for Severe Childhood Obesity in Poland: A 7-Year Gap Between Onset and Specialized Care
Delayed Intervention for Severe Childhood Obesity in Poland: A 7-Year Gap Between Onset and Specialized Care Open
Background: Childhood obesity is a growing global health concern, with an increasing prevalence of severe obesity among young children. This study aimed to determine the average age of severe obesity onset in Polish children and evaluate t…
View article: Orthorexia Nervosa Tendencies in Two Cohorts of Polish Young Adults: A Comparative Analysis of Prevalence, Correlates, and Comorbidity
Orthorexia Nervosa Tendencies in Two Cohorts of Polish Young Adults: A Comparative Analysis of Prevalence, Correlates, and Comorbidity Open
Background: The rising focus on dietary choices has contributed to maladaptive eating patterns, including orthorexia nervosa (ON)—a pathological preoccupation with healthy eating. This study investigated ON prevalence and correlates in two…
View article: Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity
Serum leptin and its relation to body composition, puberty, and metabolism in severe obesity Open
Childhood severe obesity (SO) is a growing public health concern. Leptin (LEP) and its biologically active fraction (BioLEP) play a key role in energy balance and body mass regulation. Understanding their relationship with anthropometric a…
View article: Hypertension in children with intellectual disabilities: a population not to be overseen
Hypertension in children with intellectual disabilities: a population not to be overseen Open
Hypertension (HTN) is a significant public health concern affecting individuals across all age groups, including those with and without disabilities. Among children and adolescents, particularly those with intellectual disabilities, the ri…
View article: High Prevalence of Metabolic-Associated Fatty Liver Disease (MAFLD) in Children and Adolescents with Severe Obesity
High Prevalence of Metabolic-Associated Fatty Liver Disease (MAFLD) in Children and Adolescents with Severe Obesity Open
Background: Severe obesity in children and adolescents presents a particular health burden due to high prevalence of complications and comorbidities, including metabolic-associated fatty liver disease (MAFLD). The aim of this study was to …
View article: Consumer attitudes towards dietary behaviors: a mediator between socioeconomic status and diet quality in European adults
Consumer attitudes towards dietary behaviors: a mediator between socioeconomic status and diet quality in European adults Open
Background Socioeconomic disparities in dietary behaviors are well-known, but underlying mechanisms are not fully understood. We investigated whether consumer attitudes toward dietary behaviors mediate the relationship between socioeconomi…
View article: Evaluation of Taste Perception and Olfactory Function in Adolescents in Relation to the Duration of Type 1 Diabetes
Evaluation of Taste Perception and Olfactory Function in Adolescents in Relation to the Duration of Type 1 Diabetes Open
Background: Olfactory dysfunction may be one of the clinical symptoms of neuropathy in diabetics. It is also known that taste and smell disorders in diabetes may impact dietary adherence and, consequently, good glycemic control. The study …
View article: Effectiveness of Comprehensive Lifestyle Correction with a Personalized Nutrition, Physical Activity, and Psychological Support Program in Children with Overweight and Obesity (Literature Review, Clinical Cases Description)
Effectiveness of Comprehensive Lifestyle Correction with a Personalized Nutrition, Physical Activity, and Psychological Support Program in Children with Overweight and Obesity (Literature Review, Clinical Cases Description) Open
Introduction. Childhood overweight and obesity pose significant public health challenges, strongly associated with metabolic disorders such as insulin resistance, dyslipidemia, and chronic inflammation. Comprehensive interventions addressi…
View article: Prevalence of Abdominal Obesity in Children and Adolescents with Intellectual Disability in Southeastern Poland
Prevalence of Abdominal Obesity in Children and Adolescents with Intellectual Disability in Southeastern Poland Open
Background/Objectives: The aim of the study was to determine the frequency of occurrence of a significant health problem—abdominal obesity (AO)—in children and adolescents with intellectual disability (ID) compared to children and adolesce…
View article: The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity
The Effect of Maternal Diet and Lifestyle on the Risk of Childhood Obesity Open
Background/Objectives: Childhood obesity is a global health problem that affects at least 41 million children under the age of five. Increased BMI in children is associated with serious long-term health consequences, such as type 2 diabete…
View article: Orthorexia as an Eating Disorder Spectrum—A Review of the Literature
Orthorexia as an Eating Disorder Spectrum—A Review of the Literature Open
Background: The purpose of this study is to compare and analyze research studies focused on orthorexia nervosa (ON) as a spectrum of eating disorders, and to summarize potential risk factors in different age and social groups. ON is charac…
View article: Role of chemerin in the metabolic regulation of type 1 diabetes in children
Role of chemerin in the metabolic regulation of type 1 diabetes in children Open
Introduction and objective: Type 1 diabetes is one of the most common chronic diseases of childhood, leading to the development of chronic micro- and macrovascular complications. Recently, many researchers have been focusing their efforts …
View article: Factors beyond Body Mass Index Associated with Cardiometabolic Risk among Children with Severe Obesity
Factors beyond Body Mass Index Associated with Cardiometabolic Risk among Children with Severe Obesity Open
Background: The increasing prevalence of severe obesity among children and adolescents poses a significant challenge for pediatricians and general practitioners. This study aimed to investigate the relationships between biochemical results…
View article: Age- and Sex-Specific Reference Percentile Curves for Accelerometry-Measured Physical Activity in Healthy European Children
Age- and Sex-Specific Reference Percentile Curves for Accelerometry-Measured Physical Activity in Healthy European Children Open
PURPOSE: Physical activity measured by accelerometry (PA-accelerometry) is used as an indicator of disease severity in chronic diseases. Currently, only fragmented age ranges of reference percentile curves are available for European childr…
View article: Considering Multiple Parameters beyond BMI Alone Provides a Better Understanding of Cardiometabolic Risks Associated with Severe Obesity in Children
Considering Multiple Parameters beyond BMI Alone Provides a Better Understanding of Cardiometabolic Risks Associated with Severe Obesity in Children Open
Background: The increasing prevalence of severe obesity among children and adolescents poses a significant challenge for pediatricians and general practitioners. This study aimed to investigate the relationships between biochemical results…
View article: Teenage parents and their children—position paper of the European academy of paediatrics and the European confederation of primary care paediatricians
Teenage parents and their children—position paper of the European academy of paediatrics and the European confederation of primary care paediatricians Open
Introduction Teenage parenthood presents multifaceted implications, affecting adolescent parents, their children, and extended families. Despite a decrease in teenage pregnancy rates across Europe, the phenomenon continues to present signi…
View article: Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children
Progranulin and Vaspin as Potential Novel Markers in the Etiology of Type 1 Diabetes in Children Open
Background and Objectives: Diabetes is a significant health problem, prompting the search for new therapeutic strategies. Recently, researchers have focused on identifying novel markers for the progression of this condition. It is well est…