Anna Aulinas
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View article: Real-World Data on the Efficacy and Safety of Osilodrostat in Patients with Cushing’s Disease in Spain
Real-World Data on the Efficacy and Safety of Osilodrostat in Patients with Cushing’s Disease in Spain Open
Objective: To evaluate the efficacy and safety of osilodrostat in patients with Cushing’s disease (CD). Methods: A retrospective, multicenter, real-world study of patients with CD. The main efficacy endpoint was the proportion of patients …
View article: SAT-051 Prolonged intranasal oxytocin treatment effects on reproductive hormones in adults with obesity
SAT-051 Prolonged intranasal oxytocin treatment effects on reproductive hormones in adults with obesity Open
Disclosure: F. Galbiati: None. S. Hiranandani: None. M. Wronski: None. F. Plessow: Inventor on US provisional patent application no. 63/467,980 (Oxytocin-based therapeutics to improve cognitive control in individuals with attention deficit…
View article: Predictors of therapeutic failure in GH and prolactin co-secreting pituitary adenomas
Predictors of therapeutic failure in GH and prolactin co-secreting pituitary adenomas Open
Aim To evaluate which factors are associated with a higher probability of failure to surgical and first-generation somatostatin receptor ligands (fgSRLs) treatment in patients with growth hormone and prolactin co-secreting pituitary adenom…
View article: Corrigendum: Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study
Corrigendum: Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study Open
[This corrects the article DOI: 10.3389/fendo.2024.1410080.].
View article: Central hypothyroidism and cardiovascular disease: A Spanish cohort observational study
Central hypothyroidism and cardiovascular disease: A Spanish cohort observational study Open
Purpose Little is known about cardiovascular (CV) risk in patients with central hypothyroidism (CeH). Herein, we describe prevalent and incident cardiovascular risk factors (CVRFs), cardiovascular diseases (CVDs), and mortality in adults w…
View article: Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study
Predictors of conversion to surgery in pituitary apoplexy: Insights from a Spanish multicenter observational study Open
View article: Validation and Limitations of the PANOMEN-3 Predictive Model for Tumor Recurrence and Progression in Pituitary Tumors
Validation and Limitations of the PANOMEN-3 Predictive Model for Tumor Recurrence and Progression in Pituitary Tumors Open
Context It has been proposed that the PANOMEN-3 classification may be useful to guide the prognosis and therapy of patients with pituitary tumors (PTs). However, the model has not yet been validated to date in order to assess its usefulnes…
View article: Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage
Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage Open
Context Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in hypopituitarism and hypothalamic damage (HHD). Identifying an applicable and reliable test to diagnose OXT-D is an unmet need. Melatonin (MEL) might be a c…
View article: The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease
The Oxytocin System and Implications for Oxytocin Deficiency in Hypothalamic-Pituitary Disease Open
Oxytocin (OXT) is a hypothalamic-posterior pituitary hormone with multiple effects, ranging from regulation of energy homeostasis to bone health and psychological well-being, in addition to its well-known effects on labor and lactation. Pa…
View article: Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study
Outcomes of transsphenoidal surgery for pituitary adenomas in Spain: a retrospective multicenter study Open
Background The outcomes of transsphenoidal surgery (TSS) for pituitary adenoma (PA) depend on many factors, including the availability of an expert team and the volume of surgeries performed. Data on the outcomes of TSS for PA are scarce i…
View article: Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial
Oxytocin levels in response to CRH administration in hypopituitarism and hypothalamic damage: a randomized, crossover, placebo-controlled trial Open
View article: Increased copeptin may reflect vasopressin‐related metabolic changes after bariatric surgery
Increased copeptin may reflect vasopressin‐related metabolic changes after bariatric surgery Open
Objective Mechanisms underlying metabolic improvement following metabolic and bariatric surgery (MBS) may provide insight into novel therapies. Vasopressin improves body composition and protects against hypoglycemia. Associations of copept…
View article: Sellar and perisellar meningiomas: effects on pituitary function in a Spanish observational study
Sellar and perisellar meningiomas: effects on pituitary function in a Spanish observational study Open
Purpose Studies focused on the effects of sellar and/or perisellar (S/PS) meningiomas on pituitary function are scarce. We evaluate the clinical characteristics, therapeutic outcomes, and the effects that S/PS meningiomas and their treatme…
View article: Blood DNA methylation of CRF and its association with amygdala volume and mood in Cushing’s syndrome
Blood DNA methylation of CRF and its association with amygdala volume and mood in Cushing’s syndrome Open
Objective The impact of chronic exposure to stress or glucocorticoids on psychiatric symptoms has been exemplified by cases of iatrogenic or endogenous hypercortisolism such as Cushing’s syndrome (CS). The amygdala plays an important role …
View article: 7458 Eight Weeks Intranasal Oxytocin vs. Placebo Does Not Impact Circulating Oxytocin or Arginine-Vasopressin Levels in Adults With Obesity
7458 Eight Weeks Intranasal Oxytocin vs. Placebo Does Not Impact Circulating Oxytocin or Arginine-Vasopressin Levels in Adults With Obesity Open
Disclosure: A. Aulinas: None. F. Galbiati: None. M. Wronski: None. C.S. Carter: None. J. Davis: None. H.P. Nazarloo: None. K. Holman: None. G. Julia: None. E. Asanza: None. S.E. Smith: None. L. Kerem: None. F. Plessow: None. E.A. Lawson: R…
View article: ERRATUM: Pegvisomant and pasireotide in PRL and GH co-secreting vs GH-secreting Pit-NETs
ERRATUM: Pegvisomant and pasireotide in PRL and GH co-secreting vs GH-secreting Pit-NETs Open
View article: Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study
Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study Open
Introduction Patients with Cushing’s syndrome (CS) in remission show sustained fatigue, myopathy, and an increased prevalence of sarcopenia. The mechanisms that determine these persistent muscle problems are not well known. We aimed to ide…
View article: Personalized Medicine in Acromegaly: The ACROFAST Study
Personalized Medicine in Acromegaly: The ACROFAST Study Open
Context Medical treatment of acromegaly is currently performed through a trial-and-error approach using first-generation somatostatin receptor ligands (fgSRLs) as first-line drugs, with an effectiveness of about 50%, and subsequent drugs a…
View article: Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With <scp>ARFID</scp>
Medical Comorbidities, Nutritional Markers, and Cardiovascular Risk Markers in Youth With <span>ARFID</span> Open
Objective Avoidant/restrictive food intake disorder (ARFID) is common among populations with nutrition‐related medical conditions. Less is known about the medical comorbidity/complication frequencies in youth with ARFID. We evaluated the m…
View article: Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study
Natural history and surgical outcomes of Rathke’s cleft cysts: a Spanish multicenter study Open
Rathke’s cleft cysts (RCC) are a common type of lesion found in the sellar or suprasellar area. They are usually monitored clinically, but in some cases, surgery may be required. However, their natural progression is not yet well understoo…
View article: Glucose metabolism outcomes after pituitary surgery in patients with acromegaly
Glucose metabolism outcomes after pituitary surgery in patients with acromegaly Open
Aim: To investigate the impact of pituitary surgery on glucose metabolism and to identify predictors of remission of diabetes after pituitary surgery in patients with acromegaly. Methods: A national multicenter retrospective study of patie…
View article: Integrative clinical, hormonal, and molecular data associate with invasiveness in acromegaly: REMAH study
Integrative clinical, hormonal, and molecular data associate with invasiveness in acromegaly: REMAH study Open
Introduction Growth hormone (GH)-secreting pituitary tumors (GHomas) are the most common acromegaly cause. At diagnosis, most of them are macroadenomas, and up to 56% display cavernous sinus invasion. Biomarker assessment associated with t…
View article: Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey
Venous thromboembolism in Cushing syndrome: results from an EuRRECa and Endo-ERN survey Open
Background Patients with Cushing syndrome (CS) are at increased risk of venous thromboembolism (VTE). Objective The aim was to evaluate the current management of new cases of CS with a focus on VTE and thromboprophylaxis. Design and method…
View article: Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly
Revisiting the usefulness of the short acute octreotide test to predict treatment outcomes in acromegaly Open
Introduction We previously described that a short version of the acute octreotide test (sAOT) can predict the response to first-generation somatostatin receptor ligands (SRLs) in patients with acromegaly. We have prospectively reassessed t…
View article: Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia
Clinical and outcome comparison of genetically positive vs. negative patients in a large cohort of suspected familial hypocalciuric hypercalcemia Open
Objective Biochemical suspicion of familial hypocalciuric hypercalcemia (FHH) might provide with a negative (FHH-negative) or positive (FHH-positive) genetic result. Understanding the differences between both groups may refine the identifi…
View article: Oxytocin response to food intake in avoidant/restrictive food intake disorder
Oxytocin response to food intake in avoidant/restrictive food intake disorder Open
Objective To investigate the response of anorexigenic oxytocin to food intake among adolescents and young adults with avoidant/restrictive food intake disorder (ARFID), a restrictive eating disorder characterized by lack of interest in foo…
View article: Clinical and Outcome Comparison of Genetically Positive Vs. Negative Patients in a Large Cohort of Suspected Familial Hypocalciuric Hypercalcemia
Clinical and Outcome Comparison of Genetically Positive Vs. Negative Patients in a Large Cohort of Suspected Familial Hypocalciuric Hypercalcemia Open
Objective Biochemical suspicion of familial hypocalciuric hypercalcemia (FHH) might provide with a negative (FHH-negative) or positive (FHH-positive) genetic result. Understanding the differences between both groups may refine the identifi…
View article: Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors
Molecular characterization of epithelial-mesenchymal transition and medical treatment related-genes in non-functioning pituitary neuroendocrine tumors Open
Introduction Different medical therapies have been developed for pituitary adenomas. However, Non-Functioning Pituitary Neuroendocrine Tumors (NF-PitNET) have shown little response to them. Furthermore, epithelial-mesenchymal transition (E…
View article: Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior
Low oxytocin levels are broadly associated with more pronounced psychopathology in anorexia nervosa with primarily restricting but not binge/purge eating behavior Open
Objective Anorexia nervosa (AN) is commonly associated with depression, anxiety, and deficits in socioemotional functioning. Basal levels of oxytocin, a neurohormone with antidepressant, anxiolytic, and prosocial properties, are low in wom…
View article: 11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature
11-Deoxycorticosterone Producing Adrenal Hyperplasia as a Very Unusual Cause of Endocrine Hypertension: Case Report and Systematic Review of the Literature Open
Background and Objectives 11-deoxycorticosterone overproduction due to an adrenal tumor or hyperplasia is a very rare cause of mineralocorticoid-induced hypertension. The objective is to provide the most relevant clinical features that cli…