Anna B. Meier
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View article: Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder: evidence from patients and models of the disease
Pantethine ameliorates dilated cardiomyopathy features in PPCS deficiency disorder: evidence from patients and models of the disease Open
Background PPCS deficiency disorder (PPCS DD) is an ultra-rare, autosomal recessive form of dilated cardiomyopathy (DCM) caused by pathogenic variants in PPCS, which encodes the enzyme catalyzing the second step in the coenzyme A (CoA) bio…
View article: Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease
Epicardioid single-cell genomics uncovers principles of human epicardium biology in heart development and disease Open
The epicardium, the mesothelial envelope of the vertebrate heart, is the source of multiple cardiac cell lineages during embryonic development and provides signals that are essential to myocardial growth and repair. Here we generate self-o…
View article: High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus
High-throughput optical action potential recordings in hiPSC-derived cardiomyocytes with a genetically encoded voltage indicator in the AAVS1 locus Open
Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) represent an excellent in vitro model in cardiovascular research. Changes in their action potential (AP) dynamics convey information that is essential for dise…
View article: Organoids as tools for fundamental discovery and translation—a Keystone Symposia report
Organoids as tools for fundamental discovery and translation—a Keystone Symposia report Open
Complex three‐dimensional in vitro organ‐like models, or organoids, offer a unique biological tool with distinct advantages over two‐dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex…
View article: Retinoic acid signaling modulation guides <i>in vitro</i> specification of human heart field-specific progenitor pools
Retinoic acid signaling modulation guides <i>in vitro</i> specification of human heart field-specific progenitor pools Open
Cardiogenesis relies on the precise spatiotemporal coordination of multiple progenitor populations. Understanding the specification and differentiation of these distinct progenitor pools during human embryonic development is crucial for ad…
View article: Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish
Granulocyte Colony-Stimulating Factor Mediated Regulation of Early Myeloid Cells in Zebrafish Open
Background: Colony-stimulating factor 3 (CSF3), more commonly known as granulocyte colony-stimulating factor (G-CSF), acts via a specific cell surface receptor CSF3R (or G-CSFR) to regulate hematopoiesis, with a particularly key role in th…
View article: Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome
Cell cycle defects underlie childhood-onset cardiomyopathy associated with Noonan syndrome Open
Childhood-onset myocardial hypertrophy and cardiomyopathic changes are associated with significant morbidity and mortality in early life, particularly in patients with Noonan syndrome, a multisystemic genetic disorder caused by autosomal d…
View article: Primate heart regeneration<i>via</i>migration and fibroblast repulsion by human heart progenitors
Primate heart regeneration<i>via</i>migration and fibroblast repulsion by human heart progenitors Open
SUMMARY Human heart regeneration is one of the most critical unmet clinical needs at a global level 1 . Muscular regeneration is hampered both by the limited renewing capacity of adult cardiomyocytes 2-4 and the onset of cardiac fibrosis 5…