Anna Bachmann
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View article: Efficacy of Praziquantel for Treatment of <i>Plasmodium falciparum</i> Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial
Efficacy of Praziquantel for Treatment of <i>Plasmodium falciparum</i> Infection in Asymptomatic Gabonese Adults: A Double-Blind Placebo-Controlled Randomized Trial Open
Background Schistosomiasis and malaria are major poverty-related parasitic infectious diseases. They are often coendemic and affect similar target populations. Mass drug administration and intermittent preventive treatment programs are com…
View article: Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
Full text Figures and data Side by side Abstract eLife assessment Introduction Results Discussion Materials and methods Data availability References Peer review Author response Article and author information Abstract The pathogenesis of se…
View article: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Reviewer #1 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Reviewer #1 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Reviewer #2 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Reviewer #2 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Reviewer #3 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Reviewer #3 (Public Review): A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Erratum for Wichers-Misterek et al., “A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission”
Erratum for Wichers-Misterek et al., “A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission” Open
Volume 14, no. 1, e03318-23, 2023, https://doi.org/10.1128/mbio.03318-22. Page 10, Fig. 5A and B: Parts of the colored markups (yellow, green, and magenta) are missing. The panels should appear as shown below.
View article: The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections
The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections Open
Controlled human malaria infections (CHMI) are a valuable tool to study parasite gene expression in vivo under defined conditions. In previous studies, virulence gene expression was analyzed in samples from volunteers infected with the Pla…
View article: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
Author Response: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: A novel computational pipeline for <i>var</i> gene expression augments the discovery of changes in the <i>Plasmodium falciparum</i> transcriptome during transition from <i>in vivo</i> to short-term <i>in vitro</i> culture
A novel computational pipeline for <i>var</i> gene expression augments the discovery of changes in the <i>Plasmodium falciparum</i> transcriptome during transition from <i>in vivo</i> to short-term <i>in vitro</i> culture Open
The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the high…
View article: A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission
A Microtubule-Associated Protein Is Essential for Malaria Parasite Transmission Open
A key structural feature driving the transition between different life cycle stages of the malaria parasite is the unique three-membrane pellicle, consisting of the parasite plasma membrane (PPM) and a double membrane structure underlying …
View article: The exception that proves the rule: Virulence gene expression at the onset of<i>Plasmodium falciparum</i>blood stage infections
The exception that proves the rule: Virulence gene expression at the onset of<i>Plasmodium falciparum</i>blood stage infections Open
Controlled human malaria infections (CHMI) are a valuable tool to study parasite gene expression in vivo under defined conditions. In previous studies, virulence gene expression was analyzed in samples from volunteers infected with the Pla…
View article: CD36—A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection
CD36—A Host Receptor Necessary for Malaria Parasites to Establish and Maintain Infection Open
Plasmodium falciparum-infected erythrocytes (PfIEs) present P. falciparum erythrocyte membrane protein 1 proteins (PfEMP1s) on the cell surface, via which they cytoadhere to various endothelial cell receptors (ECRs) on the walls of human b…
View article: A microtubule associated protein is essential for malaria parasite transmission
A microtubule associated protein is essential for malaria parasite transmission Open
Mature gametocytes of Plasmodium ( P .) falciparum display a banana (falciform) shape conferred by a complex array of subpellicular microtubules (SPMT) associated to the inner membrane complex (IMC). Microtubule associated proteins (MAPs) …
View article: In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma
In vitro neutrophil migration is associated with inhaled corticosteroid treatment and serum cytokines in pediatric asthma Open
Background: Different asthma phenotypes are driven by molecular endotypes. A Th1-high phenotype is linked to severe, therapy-refractory asthma, subclinical infections and neutrophil inflammation. Previously, we found neutrophil granulocyte…
View article: The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression
The Putative Bromodomain Protein PfBDP7 of the Human Malaria Parasite Plasmodium Falciparum Cooperates With PfBDP1 in the Silencing of Variant Surface Antigen Expression Open
Epigenetic regulation is a critical mechanism in controlling virulence, differentiation, and survival of the human malaria parasite Plasmodium (P.) falciparum . Bromodomain proteins contribute to this process by binding to acetylated lysin…
View article: PMRT1, a <i>Plasmodium</i> -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development
PMRT1, a <i>Plasmodium</i> -Specific Parasite Plasma Membrane Transporter, Is Essential for Asexual and Sexual Blood Stage Development Open
Plasmodium falciparum -infected erythrocytes possess multiple compartments with designated membranes. Transporter proteins embedded in these membranes not only facilitate movement of nutrients, metabolites, and other molecules between thes…
View article: PMRT1, a<i>Plasmodium</i>specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development
PMRT1, a<i>Plasmodium</i>specific parasite plasma membrane transporter is essential for asexual and sexual blood stage development Open
Membrane transport proteins perform crucial roles in cell physiology. The obligate intracellular parasite Plasmodium falciparum , an agent of human malaria, relies on membrane transport proteins for the uptake of nutrients from the host, d…
View article: Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite <i>Plasmodium falciparum</i>
Characterization of apicomplexan amino acid transporters (ApiATs) in the malaria parasite <i>Plasmodium falciparum</i> Open
During the symptomatic human blood phase, malaria parasites replicate within red blood cells. Parasite proliferation relies on the uptake of nutrients, such as amino acids, from the host cell and the blood plasma, requiring transport acros…
View article: Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma
Altered Cytokine Response of Human Brain Endothelial Cells after Stimulation with Malaria Patient Plasma Open
Infections with the deadliest malaria parasite, Plasmodium falciparum, are accompanied by a strong immunological response of the human host. To date, more than 30 cytokines have been detected in elevated levels in plasma of malaria patient…
View article: Common virulence gene expression in adult first-time infected malaria patients and severe cases
Common virulence gene expression in adult first-time infected malaria patients and severe cases Open
Sequestration of Plasmodium falciparum ( P. falciparum )-infected erythrocytes to host endothelium through the parasite-derived P. falciparum erythrocyte membrane protein 1 ( Pf EMP1) adhesion proteins is central to the development of mala…
View article: Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite <scp> <i>Plasmodium falciparum</i> </scp>
Identification of novel inner membrane complex and apical annuli proteins of the malaria parasite <span> <i>Plasmodium falciparum</i> </span> Open
The inner membrane complex (IMC) is a defining feature of apicomplexan parasites, which confers stability and shape to the cell, functions as a scaffolding compartment during the formation of daughter cells and plays an important role in m…