Anna Bäck
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View article: A semi‐automated workflow for cohort‐wise preparation of radiotherapy data for dose‐response modeling, including autosegmentation of organs at risk
A semi‐automated workflow for cohort‐wise preparation of radiotherapy data for dose‐response modeling, including autosegmentation of organs at risk Open
Background Preparing retrospective dose data for risk modeling using large study cohorts can be time consuming as it often requires patient‐wise manual interventions. This is especially the case when considering organs at risk (OARs) not s…
View article: Three-dimensional dose uncertainty maps based on the fraction of field edge dose for volumetric modulated arc therapy plans
Three-dimensional dose uncertainty maps based on the fraction of field edge dose for volumetric modulated arc therapy plans Open
3DUMFED offers a way to estimate dose uncertainties related to the field edge in 3D. It also allows for separate evaluation in different regions of interest, unlike EAM, which mainly correlates with the dose uncertainty related to the PTV.
View article: Risk Stratification for Trial Enrichment Considering Loco‐Regional Failure in Head and Neck Cancer: <scp>UICC8</scp> Versus Purpose‐Built Failure‐Type Specific Risk Prediction Model
Risk Stratification for Trial Enrichment Considering Loco‐Regional Failure in Head and Neck Cancer: <span>UICC8</span> Versus Purpose‐Built Failure‐Type Specific Risk Prediction Model Open
Background A previously published failure‐type specific risk model showed good performance in the original cohort. Aim: to validate the model and separate patients with high‐ and low‐risk loco‐regional failure (LRF). Goal: to identify pati…
View article: Assessment of radiation pneumonitis and predictive factors in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy
Assessment of radiation pneumonitis and predictive factors in patients with locally advanced non-small cell lung cancer treated with chemoradiotherapy Open
Purpose: Radiation pneumonitis (RP) is a dose-limiting toxicity associated with increased mortality for patients with non-small cell lung cancer (NSCLC) treated with chemoradiotherapy (CRT). This study aims to assess the incidence of sympt…
View article: Impact of delivery variations on 3D dose distributions for volumetric modulated arc therapy plans of various complexity
Impact of delivery variations on 3D dose distributions for volumetric modulated arc therapy plans of various complexity Open
Background Delivery variations during radiotherapy can cause discrepancies between planned and delivered dose distribution. These variations could arise from random and systematic offsets in certain machine parameters or systematic offsets…
View article: Prediction of proton stopping power ratios using dual‐energy CT basis material decomposition
Prediction of proton stopping power ratios using dual‐energy CT basis material decomposition Open
Background Proton radiotherapy treatment plans are currently restricted by the range uncertainties originating from the stopping power ratio (SPR) prediction based on single‐energy computed tomography (SECT). Various studies have shown tha…
View article: Different aspects of plan complexity in prostate VMAT plans
Different aspects of plan complexity in prostate VMAT plans Open
In this work we evaluated VMAT plan complexity by using different methods and approaches: complexity related to the aperture shape, the nature of the dynamic delivery, the impact of delivery variations as well as complexity analyses based …
View article: Impact of delineation errors on the estimated organ at risk dose and of dose errors on the normal tissue complication probability model
Impact of delineation errors on the estimated organ at risk dose and of dose errors on the normal tissue complication probability model Open
Background Normal tissue complication probability (NTCP) models are often based on doses retrieved from delineated volumes. For retrospective dose‐response studies focusing on organs that have not been delineated historically, automatic se…
View article: Evaluation of measures related to dosimetric uncertainty of VMAT plans
Evaluation of measures related to dosimetric uncertainty of VMAT plans Open
Dosimetric uncertainty is most often not included in the process of creating and selecting plans for treatment. Treatment planning and the physician's choice of treatment plan is instead often based only on evaluation of clinical goals of …
View article: P091: Early analysis of the PRO-Hodgkin study: Clinical investigation of pencil beam scanning proton treatment in Hodgkin lymphoma patients
P091: Early analysis of the PRO-Hodgkin study: Clinical investigation of pencil beam scanning proton treatment in Hodgkin lymphoma patients Open
Background: Most stage I-IIA classical Hodgkin lymphoma (cHL) patients are cured with limited chemotherapy followed by radiotherapy (RT), with a risk of late toxicity from RT. The dose to normal tissue can be minimized with proton therapy …
View article: Dosimetric effects of respiratory motion during stereotactic body radiation therapy of lung tumors
Dosimetric effects of respiratory motion during stereotactic body radiation therapy of lung tumors Open
The dosimetric effects of respiratory-induced motion during lung SBRT are patient and plan specific. The magnitude of the dosimetric effect cannot be assessed solely based upon tumor motion amplitude or plan complexity.
View article: Surface guided frameless positioning for lung stereotactic body radiation therapy
Surface guided frameless positioning for lung stereotactic body radiation therapy Open
Background and purpose When treating lung tumors with stereotactic body radiation therapy (SBRT), patient immobilization is of outmost importance. In this study, the intra‐fractional shifts of the patient (based on bony anatomy) and the tu…
View article: COMPARISON OF METAL ARTEFACTS FOR DIFFERENT DUAL ENERGY CT TECHNIQUES
COMPARISON OF METAL ARTEFACTS FOR DIFFERENT DUAL ENERGY CT TECHNIQUES Open
This study compares dual-energy computed tomography (DECT) images of a phantom including different material inserts and with additional lateral titanium or stainless steel inserts, simulating bilateral hip prostheses. Dual-source (DS) and …
View article: What is plan quality in radiotherapy? The importance of evaluating dose metrics, complexity, and robustness of treatment plans
What is plan quality in radiotherapy? The importance of evaluating dose metrics, complexity, and robustness of treatment plans Open
Plan evaluation is a key step in the radiotherapy treatment workflow. Central to this step is the assessment of treatment plan quality. Hence, it is important to agree on what we mean by plan quality and to be fully aware of which paramete…
View article: Analysis of early respiratory-related mortality after radiation therapy of non-small-cell lung cancer: feasibility of automatic data extraction for dose–response studies
Analysis of early respiratory-related mortality after radiation therapy of non-small-cell lung cancer: feasibility of automatic data extraction for dose–response studies Open
Purpose: To examine the feasibility of automatic data extraction from clinical radiation therapy (RT) databases at four hospitals to investigate the impact of mean lung dose (MLD) and age on the risk of early respiratory-related death and …
View article: Harmonization of proton treatment planning for head and neck cancer using pencil beam scanning: first report of the IPACS collaboration group
Harmonization of proton treatment planning for head and neck cancer using pencil beam scanning: first report of the IPACS collaboration group Open
Background and purpose: A collaborative network between proton therapy (PT) centres in Trento in Italy, Poland, Austria, Czech Republic and Sweden (IPACS) was founded to implement trials and harmonize PT. This is the first report of IPACS …
View article: Impact of lung density on the lung dose estimation for radiotherapy of breast cancer
Impact of lung density on the lung dose estimation for radiotherapy of breast cancer Open
Background and purpose: To investigate the impact of the clinical implementation of a deterministic particle transport method on the lung dose evaluation for radiotherapy of breast cancer focusing on dosimetric effects of the lung density.…
View article: Complexity metric based on fraction of penumbra dose - initial study
Complexity metric based on fraction of penumbra dose - initial study Open
Volumetric modulated arc therapy improve radiotherapy outcome for many patients compared to conventional three dimensional conformal radiotherapy but require a more extensive, most often measurement based, quality assurance. Multi leaf col…