Anna Batorsky
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View article: Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain
Baseline characteristics of participants in the Biomarkers for Evaluating Spine Treatments clinical trial: a sequential multiple assignment randomized trial for chronic low back pain Open
Objective Chronic low back pain (cLBP) is a significant public health problem in the United States. A method to identify treatments that are most likely effective for an individual patient based on their unique characteristics is needed. M…
View article: The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial
The design and rationale of the Biomarkers for Evaluating Spine Treatments trial: a sequential multiple assignment randomized trial Open
Objective Chronic low back pain (cLBP) is a common condition that impacts quality of life and function. There are many evidence-based treatments to address cLBP; however, treatment effects are modest, perhaps in part due to individual vari…
View article: Integrating randomized and observational studies to estimate optimal dynamic treatment regimes
Integrating randomized and observational studies to estimate optimal dynamic treatment regimes Open
Sequential multiple assignment randomized trials (SMARTs) are the gold standard for estimating optimal dynamic treatment regimes (DTRs), but are costly and require a large sample size. We introduce the multi-stage augmented Q-learning esti…
View article: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci Open
Background: DNA methylation (DNAm) is associated with gene regulation and estimated glomerular filtration rate (eGFR), a measure of kidney function. Decreased eGFR is more common among US Hispanics and African Americans. The causes for thi…
View article: Ten‐year cross‐sectional and longitudinal assessment and factors associated with unfavourable self‐rated oral health in older adults in the United States
Ten‐year cross‐sectional and longitudinal assessment and factors associated with unfavourable self‐rated oral health in older adults in the United States Open
Objective To investigate the association of demographic and socio‐economic characteristics with self‐reported oral health (SROH) among older adults who participated in the Health and Retirement Study (HRS) in 2008, 2018, or both, and to de…
View article: The Back Pain Consortium (BACPAC) Research Program Data Harmonization: Rationale for Data Elements and Standards
The Back Pain Consortium (BACPAC) Research Program Data Harmonization: Rationale for Data Elements and Standards Open
Objective One aim of the Back Pain Consortium (BACPAC) Research Program is to develop an integrated model of chronic low back pain that is informed by combined data from translational research and clinical trials. We describe efforts to ma…
View article: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci Open
Trans-ethnic meta-analysis results for eGFR EWAS Description of variables: CpG CPG name chr Chromosome pos_hg38 Position hg38 Beta Effect SE Standard error P P value totalsamplesize number of participants direction direction of effec…
View article: Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci Open
Trans-ethnic meta-analysis results for eGFR EWAS Description of variables: CpG CPG name chr Chromosome pos_hg38 Position hg38 Beta Effect SE Standard error P P value totalsamplesize number of participants direction direction of effec…
View article: Additional file 3 of Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
Additional file 3 of Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci Open
Additional file 3: Supplementary Tables. Tables S1 to S5. Descriptive characteristics, quality control and processing, and results.
View article: Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci
Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci Open
Significance Statement The absence of high-resolution epigenomic maps of key kidney cell types has hampered understanding of kidney-specific genome regulation in health and disease. Kidney-associated genetic variants, identified in genome-…