Abigail J. Beer
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View article: microRNA Biomarkers in Paediatric Infection Diagnostics—Bridging the Gap Between Evidence and Clinical Application: A Scoping Review
microRNA Biomarkers in Paediatric Infection Diagnostics—Bridging the Gap Between Evidence and Clinical Application: A Scoping Review Open
Background: Distinguishing between bacterial and viral infections in children remains a significant challenge for clinicians. Traditional biomarkers have limited utility, often leading to antibiotic overprescription due to clinician uncert…
View article: microRNA Biomarkers in Paediatric Infection Diagnostics. Bridging the Gap Between Evidence and Clinical Application: A Scoping Review
microRNA Biomarkers in Paediatric Infection Diagnostics. Bridging the Gap Between Evidence and Clinical Application: A Scoping Review Open
Objective This scoping review aims to assess the evidence regarding miRNA associations with paediatric bacterial and viral infections. Introduction Febrile children present a challenge in emergency care, often leading to unnecessary antibi…
View article: Supplementary Figure 4 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 4 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 4
View article: Supplementary Figure 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 3
View article: Supplementary Figure 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 3
View article: Supplementary Figure 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 2
View article: TABLE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
ESR1 locus variants and TP53 mutation associations
View article: Supplemental Tables S1-S35 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplemental Tables S1-S35 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplemental Tables S1-S35
View article: Supplementary File 1: Supplemental Table References from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary File 1: Supplemental Table References from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplemental Information: References for Supplemental Table S5
View article: FIGURE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
FIGURE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Variant selection for validation studies. Flow chart for variant prioritization for validation studies is shown for TP53 mutation associations (A) and PIK3CA mutation associations (B). Variants were first filtered by P values, MAF, and loc…
View article: FIGURE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
FIGURE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Variant selection for validation studies. Flow chart for variant prioritization for validation studies is shown for TP53 mutation associations (A) and PIK3CA mutation associations (B). Variants were first filtered by P values, MAF, and loc…
View article: Supplementary Figure 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 1
View article: FIGURE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
FIGURE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Manhattan plots for TP53 and PIK3CA discovery GxM analyses. Discovery GWAS data for 879 TP53 mutation carriers and 1,965 breast cancer cases without TP53 mutations (A), 237 cases with TP53 GOF mutations and 1,965 breast cancer cases withou…
View article: TABLE 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
ESR1 variant associations in combined AFA datasets
View article: Supplementary File 1: Supplemental Table References from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary File 1: Supplemental Table References from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplemental Information: References for Supplemental Table S5
View article: Supplementary Figure 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 2
View article: Supplementary Figure 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 1
View article: TABLE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
ESR1 locus variants and TP53 mutation associations
View article: TABLE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
TP53 and PIK3CA somatic mutation frequencies
View article: FIGURE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
FIGURE 2 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Manhattan plots for TP53 and PIK3CA discovery GxM analyses. Discovery GWAS data for 879 TP53 mutation carriers and 1,965 breast cancer cases without TP53 mutations (A), 237 cases with TP53 GOF mutations and 1,965 breast cancer cases withou…
View article: Data from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Data from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. Emerging data suggest tumor mutation status is associated with germline variants and genetic ancestry. We aimed to identify germline vari…
View article: Supplementary Figure 4 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplementary Figure 4 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplementary Figure 4
View article: Supplemental Tables S1-S35 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Supplemental Tables S1-S35 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
Supplemental Tables S1-S35
View article: Data from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Data from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. Emerging data suggest tumor mutation status is associated with germline variants and genetic ancestry. We aimed to identify germline vari…
View article: TABLE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 1 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
TP53 and PIK3CA somatic mutation frequencies
View article: TABLE 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
TABLE 3 from Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
ESR1 variant associations in combined AFA datasets
View article: Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study
Association of <i>ESR1</i> Germline Variants with <i>TP53</i> Somatic Variants in Breast Tumors in a Genome-wide Study Open
In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. Emerging data suggest tumor mutation status is associated with germline variants and genetic ancestry. We aimed to identify germline vari…
View article: Association of<i>ESR1</i>germline variants with<i>TP53</i>somatic variants in breast tumors in a genome-wide study
Association of<i>ESR1</i>germline variants with<i>TP53</i>somatic variants in breast tumors in a genome-wide study Open
Background In breast tumors, somatic mutation frequencies in TP53 and PIK3CA vary by tumor subtype and ancestry. HER2 positive and triple negative breast cancers (TNBC) have a higher frequency of TP53 somatic mutations than other subtypes.…
View article: <i>KMT2D</i> loss drives aggressive tumor phenotypes in cutaneous squamous cell carcinoma.
<i>KMT2D</i> loss drives aggressive tumor phenotypes in cutaneous squamous cell carcinoma. Open
Cutaneous squamous cell carcinoma (cSCC) is the second most lethal skin cancer. Due to ultraviolet light-induced damage, cSCCs have a high mutation rate, but some genes are more frequently mutated in aggressive cSCCs. Lysine-specific histo…