Anna Bläckberg
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View article: Non–β-hemolytic Streptococcal Bacteremia in Patients With Heart Valve Prosthesis—Is It Always Infective Endocarditis?
Non–β-hemolytic Streptococcal Bacteremia in Patients With Heart Valve Prosthesis—Is It Always Infective Endocarditis? Open
Background Non–β-hemolytic streptococci are among the most common causative agents of infective endocarditis (IE). Patients with a heart valve prosthesis (HVP) have a high risk of IE. We aimed to determine the risk for IE in patients with …
View article: A population-based study of the appearances of enteric <i>Campylobacter</i> and non-typhoidal <i>Salmonella</i> infections on computed tomography
A population-based study of the appearances of enteric <i>Campylobacter</i> and non-typhoidal <i>Salmonella</i> infections on computed tomography Open
The most common location of Campylobacter and Salmonella infections was the cecum, followed by the ascending colon. Enteric wall edema, contrast loading of the affected mucosa, and enteric fat stranding are typical features of both infecti…
View article: <i>Campylobacter</i> Infections With and Without Bacteremia: A Comparative Retrospective Population-Based Study
<i>Campylobacter</i> Infections With and Without Bacteremia: A Comparative Retrospective Population-Based Study Open
Background Bacteremia with species in the genus Campylobacter is rare, and knowledge of the disease course in comparison with Campylobacter enteritis is limited. Methods This is a retrospective population-based study. Episodes of Campyloba…
View article: Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts
Performance of the 2023 Duke-International Society of Cardiovascular Infectious Diseases Diagnostic Criteria for Infective Endocarditis in Relation to the Modified Duke Criteria and to Clinical Management—Reanalysis of Retrospective Bacteremia Cohorts Open
Background Revised diagnostic criteria for infective endocarditis (IE), the 2023 Duke-ISCVID criteria, were recently presented and need validation. Here, we compare the 2000 modified Duke criteria for IE with Duke-ISCVID among patients wit…
View article: Eubacterium bacteremia – a retrospective observational study of a seldom found anaerobic pathogen
Eubacterium bacteremia – a retrospective observational study of a seldom found anaerobic pathogen Open
Invasive infections with Eubacterium have a low incidence. The condition has a low mortality and an abdominal focus of infection, and malignancy, is common.
View article: Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population- based retrospective cohort study
Non-betahemolytic streptococcal bacteremia, cardiac implantable electronic device, endocarditis, extraction, and outcome; a population- based retrospective cohort study Open
Purpose Patients with non-beta-hemolytic streptococcal bacteremia (NBHSB) are at risk of infective endocarditis (IE). Patients with cardiac implantable electronic device (CIED) have been described to have an increased risk of IE. The aim o…
View article: Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow
Dissecting the properties of circulating IgG against Group A Streptococcus through a combined systems antigenomics-serology workflow Open
Most individuals maintain circulating antibodies against various pathogenic bacteria as a consequence of previous exposures. However, it remains unclear to what extent these antibodies contribute to host protection. This knowledge gap is l…
View article: A population-based study on the incidence, risk factors and outcome of Salmonella bloodstream infections in South Sweden 2012-2022
A population-based study on the incidence, risk factors and outcome of Salmonella bloodstream infections in South Sweden 2012-2022 Open
Introduction: Invasive infections caused by Salmonella are a significant global health concern. This population-based study aimed to comprehensively analyze invasive Salmonella infections in South Sweden, focusing on incidence, clinical pr…
View article: A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess
A Population-Based Study of Unfavorable Prognostic Factors Associated With Pyogenic Liver Abscess Open
Background Pyogenic liver abscess (PLA) is a rare entity that is associated with substantial mortality and morbidity. Our objective was to investigate variables associated with mortality and subsequent PLA in patients diagnosed with PLA in…
View article: Infection or Contamination with <i>Rothia, Kocuria, Arthrobacter</i> and <i>Pseudoglutamicibacter—</i> a Retrospective Observational Study of Non- <i>Micrococcus Micrococcaceae</i> in the Clinic
Infection or Contamination with <i>Rothia, Kocuria, Arthrobacter</i> and <i>Pseudoglutamicibacter—</i> a Retrospective Observational Study of Non- <i>Micrococcus Micrococcaceae</i> in the Clinic Open
Rothia , Kocuria , Arthrobacter , and Pseudoglutamicibacter are bacterial species within the family Micrococcaeae . Knowledge of human infections due to these bacteria is limited.
View article: Increasing incidence of pyogenic liver abscess in Southern Sweden: a population-based study from 2011 to 2020
Increasing incidence of pyogenic liver abscess in Southern Sweden: a population-based study from 2011 to 2020 Open
The incidence of PLA increased during the study period, and Streptococcus spp., Klebsiella spp. and E. coli dominated both blood and local cultures. Despite antimicrobial therapy, pathogens could be found in local abscess cultures several …
View article: Time to positivity of blood cultures in bloodstream infections with <i>Streptococcus dysgalactiae</i> and association with outcome
Time to positivity of blood cultures in bloodstream infections with <i>Streptococcus dysgalactiae</i> and association with outcome Open
TTP may be an important prognostic indicator for 30-day mortality in patients with bloodstream infections due to S. dysgalactiae.
View article: Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies Open
The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this hum…
View article: Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies
Invasive streptococcal infection can lead to the generation of cross-strain opsonic antibodies Open
Introduction The human pathogen Streptococcus pyogenes causes substantial morbidity and mortality. It is unclear if antibodies developed after infections with this pathogen are opsonic and if they are strain-specific or more broadly protec…
View article: Time to Blood Culture Positivity: An Independent Predictor of Mortality in <i>Streptococcus Pyogenes</i> Bacteremia
Time to Blood Culture Positivity: An Independent Predictor of Mortality in <i>Streptococcus Pyogenes</i> Bacteremia Open
Background Streptococcus pyogenes bacteremia is a severe condition with high mortality. Time to blood culture positivity (TTP) is known to predict the outcome in bacteremia with other pathogens. This study aimed to determine the associatio…
View article: Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2
Spike-Dependent Opsonization Indicates Both Dose-Dependent Inhibition of Phagocytosis and That Non-Neutralizing Antibodies Can Confer Protection to SARS-CoV-2 Open
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immun…
View article: Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis
Opsonization by non-neutralizing antibodies can confer protection to SARS-CoV-2 despite Spike-dependent modulation of phagocytosis Open
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immun…
View article: Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19
Distinct phenotypes of platelet, monocyte, and neutrophil activation occur during the acute and convalescent phase of COVID-19 Open
SARS-CoV-2 has spread rapidly worldwide, causing the COVID-19 pandemic. Platelet activation and platelet-leukocyte complex formation are proposed to contribute to disease progression. Here, we report platelet and leukocyte activation durin…
View article: Lack of Opsonic Antibody Responses to Invasive Infections With Streptococcus dysgalactiae
Lack of Opsonic Antibody Responses to Invasive Infections With Streptococcus dysgalactiae Open
Introduction Streptococcus dysgalactiae can cause severe recurrent infections. This study aimed to investigate antibody responses following S. dysgalactiae bacteraemia and possible development of protective immunity. Materials and Methods …
View article: Infective endocarditis caused by HACEK group bacteria—a registry-based comparative study
Infective endocarditis caused by HACEK group bacteria—a registry-based comparative study Open
Infective endocarditis (IE) caused by bacteria within Haemophilus (excluding Haemophilus influenzae ), Aggregatibacter , Cardiobacterium , Eikenella and Kingella (HACEK) is rare. This study aimed to describe clinical features of IE caused …
View article: Antibody kinetics and clinical course of COVID-19 a prospective observational study
Antibody kinetics and clinical course of COVID-19 a prospective observational study Open
Background Serological response and association to clinical manifestation is important for understanding the pathogenesis of COVID-19. Materials and methods A prospective observational study was conducted where antibody responses of IgG an…
View article: Infective Endocarditis Due to <i>Corynebacterium</i> Species: Clinical Features and Antibiotic Resistance
Infective Endocarditis Due to <i>Corynebacterium</i> Species: Clinical Features and Antibiotic Resistance Open
Background Corynebacterium species are often dismissed as contaminants in blood cultures, but they can also cause infective endocarditis (IE), which is a severe condition. Antibiotic resistance of corynebacteria is increasing making treatm…
View article: Development of a Molecular Imprinting-Based Surface Plasmon Resonance Biosensor for Rapid and Sensitive Detection of Staphylococcus aureus Alpha Hemolysin From Human Serum
Development of a Molecular Imprinting-Based Surface Plasmon Resonance Biosensor for Rapid and Sensitive Detection of Staphylococcus aureus Alpha Hemolysin From Human Serum Open
Stapylococcus aureus is a common infectious agent in e.g. sepsis, associated with both high mortality rates and severe long-term effects. The cytolytic protein α-hemolysin has repeatedly been shown to enhance the virulence of S. aureus . C…
View article: Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test Open
The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Lifting confinement restriction and resuming to normality depends greatly on COVID-19 immunity screening. Detection of antibodies to severe …
View article: Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test
Serology assessment of antibody response to SARS-CoV-2 in patients with COVID-19 by rapid IgM/IgG antibody test Open
The coronavirus disease 2019 (COVID-19) pandemic has created a global health- and economic crisis. Detection of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes COVID-19 by serological methods is impo…
View article: Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department
Heparin-Binding Protein as a Prognostic Biomarker of Sepsis and Disease Severity at the Emergency Department Open
Objective: Rapid and early detection of patients at risk to develop sepsis remains demanding. Heparin-binding protein (HBP) has previously demonstrated good prognostic properties in detecting organ dysfunction among patients with suspected…
View article: Infective endocarditis due to Streptococcus dysgalactiae: clinical presentation and microbiological features
Infective endocarditis due to Streptococcus dysgalactiae: clinical presentation and microbiological features Open
Knowledge of infective endocarditis (IE) caused by Streptococcus dysgalactiae (SD) is limited. This study aimed to identify the clinical and microbiological features of SD-caused IE and to investigate any possible synergy between penicilli…