Anna Bode
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View article: Characteristics and clinical outcomes of patients (pts) with Acute Myeloid Leukemia (AML) with Mecom rearrangements: An analysis from the MARROW consortium
Characteristics and clinical outcomes of patients (pts) with Acute Myeloid Leukemia (AML) with Mecom rearrangements: An analysis from the MARROW consortium Open
Background: MECOM-rearranged (MECOM-r) AML is a rare AML subtype that is characterized by the disease-defining inv(3)(q21q26.2), t(3;3)(q21;q26.2), and other rare alterations involving 3q26.2. MECOM-r AML is an adverse-risk genetic abnorma…
View article: Gender Disparity in Enrollment in Clinical Trials for Hairy Cell Leukemia Treatments in the Last 40 Years
Gender Disparity in Enrollment in Clinical Trials for Hairy Cell Leukemia Treatments in the Last 40 Years Open
Background Hairy Cell Leukemia (HCL) is a B‐cell lymphoproliferative disorder that predominantly affects males, yet recent evidence suggests a notable gender participation gap in HCL clinical trials. This study aims to characterize that di…
View article: Spontaneous Polyploids and Antimutators Compete During the Evolution of <i>Saccharomyces cerevisiae</i> Mutator Cells
Spontaneous Polyploids and Antimutators Compete During the Evolution of <i>Saccharomyces cerevisiae</i> Mutator Cells Open
“Mutator” tumor cells that cannot correct DNA replication errors exhibit an extremely high mutation rate that accelerates their evolution. But this gamble puts them at risk for extinction....
View article: Spontaneous polyploids and antimutators compete during the evolution of mutator cells
Spontaneous polyploids and antimutators compete during the evolution of mutator cells Open
Heterozygous mutations affecting DNA polymerase (Pol) exonuclease domains and homozygous inactivation of mismatch repair (MMR) each generate “mutator” phenotypes capable of driving tumorigenesis. Cancers with both defects exhibit an explos…
View article: Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes
Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes Open
Significance Mutations accumulate throughout life in every cell of the body. A long-standing question is to what extent these mutations contribute to aging. Age is the single greatest risk factor for cancer, a disease driven by random muta…
View article: Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses
Structure/Function Studies of the α4 Subunit Reveal Evolutionary Loss of a GlyR Subtype Involved in Startle and Escape Responses Open
Inhibitory glycine receptors (GlyRs) are pentameric ligand-gated anion channels with major roles in startle disease/hyperekplexia (GlyR α1), cortical neuronal migration/autism spectrum disorder (GlyR α2), and inflammatory pain sensitizatio…
View article: Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia
Investigating the Mechanism by Which Gain-of-function Mutations to the α1 Glycine Receptor Cause Hyperekplexia Open
Hyperekplexia is a rare human neuromotor disorder caused by mutations that impair the efficacy of glycinergic inhibitory neurotransmission. Loss-of-function mutations in the GLRA1 or GLRB genes, which encode the α1 and β glycine receptor (…