Anna Brandi
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View article: Pangenome analysis of <i>Paenibacillus polymyxa</i> strains reveals the existence of multiple and functionally distinct <i>Paenibacillus</i> species
Pangenome analysis of <i>Paenibacillus polymyxa</i> strains reveals the existence of multiple and functionally distinct <i>Paenibacillus</i> species Open
Paenibacillus polymyxa , a Gram-positive bacterium commonly found in soil and plant roots, plays an important role in the environment due to its nitrogen-fixing ability and is renowned for producing antibiotics like polymyxin. In this stud…
View article: The hns Gene of Escherichia coli Is Transcriptionally Down-Regulated by (p)ppGpp
The hns Gene of Escherichia coli Is Transcriptionally Down-Regulated by (p)ppGpp Open
Second messenger nucleotides, such as guanosine penta- or tetra-phosphate, commonly referred to as (p)ppGpp, are powerful signaling molecules, used by all bacteria to fine-tune cellular metabolism in response to nutrient availability. Inde…
View article: Transcriptional and post-transcriptional events trigger de novo infB expression in cold stressed Escherichia coli
Transcriptional and post-transcriptional events trigger de novo infB expression in cold stressed Escherichia coli Open
After a 37 to 10°C temperature downshift the level of translation initiation factor IF2, like that of IF1 and IF3, increases at least 3-fold with respect to the ribosomes. To clarify the mechanisms and conditions leading to cold-stress ind…
View article: Translation initiation factor IF2 contributes to ribosome assembly and maturation during cold adaptation
Translation initiation factor IF2 contributes to ribosome assembly and maturation during cold adaptation Open
Cold-stress in Escherichia coli induces de novo synthesis of translation initiation factors IF1, IF2 and IF3 while ribosome synthesis and assembly slow down. Consequently, the IFs/ribosome stoichiometric ratio increases about 3-fold during…
View article: Development of a graphene oxide-based assay for the sequence-specific detection of double-stranded DNA molecules
Development of a graphene oxide-based assay for the sequence-specific detection of double-stranded DNA molecules Open
Graphene oxide (GO) is a promising material for the development of cost-effective detection systems. In this work, we have devised a simple and rapid GO-based method for the sequence-specific identification of DNA molecules generated by PC…
View article: Screening an Archetypal Collection of Microorganisms for the Presence of Unexplored Antimicrobial Compounds
Screening an Archetypal Collection of Microorganisms for the Presence of Unexplored Antimicrobial Compounds Open
WHO estimates that more than 700.000 people die every year as a result of drug-resistant infections. To tackle this problem and change the current trend, it is necessary to design advanced strategies for drug discovery and to promote early…
View article: An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions
An Interplay among FIS, H-NS, and Guanosine Tetraphosphate Modulates Transcription of the Escherichia coli cspA Gene under Physiological Growth Conditions Open
CspA, the most characterized member of the csp gene family of Escherichia coli, is highly expressed not only in response to cold stress, but also during the early phase of growth at 37°C. Here, we investigate at molecular level the antagon…