Anna Bręborowicz
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View article: Viral Infection Correlates with a Better Clinical Outcome than Pulmonary Exacerbation of Bacterial Origin in Paediatric Patients with Cystic Fibrosis
Viral Infection Correlates with a Better Clinical Outcome than Pulmonary Exacerbation of Bacterial Origin in Paediatric Patients with Cystic Fibrosis Open
Cystic fibrosis is a progressive disease affecting various organs of the human body, including the respiratory system. While the effect of bacterial infection on cystic fibrosis outcome has been comprehensively described, little is known a…
View article: Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy
Biomarker Discovery in Childhood Asthma: A Pilot Study of Serum Metabolite Analysis for IgE-Dependent Allergy Open
BACKGROUND Childhood asthma, especially in the youngest children, is difficult to diagnose and is often based on the patient's symptoms. This study compared metabolite concentrations in serum samples between 13 children with asthma and IgE…
View article: Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs
Metabolomics in Childhood Asthma – a Promising Tool to Meet Various Clinical Needs Open
Purpose of Review The aim of our review is to summarize the available literature where metabolomics was used in studies on childhood asthma, and to find metabolites that are diagnostic biomarker candidates in childhood asthma. Moreover, th…
View article: Guidelines for the diagnosis and management of asthmaby the Polish Society of Allergology, Polish Society of LungDiseases, Polish Society of Pediatric Pneumology, and PolishSociety of Family Medicine (STAN4T)
Guidelines for the diagnosis and management of asthmaby the Polish Society of Allergology, Polish Society of LungDiseases, Polish Society of Pediatric Pneumology, and PolishSociety of Family Medicine (STAN4T) Open
The updated and enhanced guidelines for the diagnosis and treatment of asthma in children and adults were developed by expert physicians from four Polish medical societies, using the GRADE methodology. The guidelines provide a concise and …
View article: Validation of Polish-Language Questionnaires for Assessing the Quality of Life of Patients with Primary Ciliary Dyskinesia (PCD-QOL)
Validation of Polish-Language Questionnaires for Assessing the Quality of Life of Patients with Primary Ciliary Dyskinesia (PCD-QOL) Open
In recent years, questionnaires were published in English to assess the quality of life of patients with PCD (Primary Ciliary Diskinesia) for adults, adolescents aged 13–17 years, and children aged 6–12 years and their caregivers. This stu…
View article: How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis?
How Does the Corrected Exhalyzer Software Change the Predictive Value of LCI in Pulmonary Exacerbations in Children with Cystic Fibrosis? Open
Aim: Recently, the most commonly used for multiple breath washout device, the Exhalyzer D, has been shown to overestimate lung clearance index (LCI) results due to a software error. Our study aimed to compare the predictive values of LCI i…
View article: Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis
Amino Acid Profiling Identifies Disease-Specific Signatures in IgE-Mediated and Non-IgE-Mediated Food Allergy in Pediatric Patients with Atopic Dermatitis Open
An IgE-mediated food allergy (FA) in atopic dermatitis (AD) children should be easily differentiated from other immune-mediated adverse effects related to food. Specific IgEs for particular protein components has provided additional diagno…
View article: Changes in Serum Protein–Peptide Patterns in Atopic Children Allergic to Plant Storage Proteins
Changes in Serum Protein–Peptide Patterns in Atopic Children Allergic to Plant Storage Proteins Open
Next to cow’s milk and eggs, plant foods, i.e., legumes, tree nuts and cereal grains, most often sensitise atopic children. Storage proteins constitutes the most relevant protein fraction of plant foods, causing primary sensitisation. They…
View article: Cytokine profile in childhood asthma
Cytokine profile in childhood asthma Open
Childhood asthma is a chronic airway disease, which pathogenesis is markedly heterogeneous–with multiple phenotypes defining visible characteristics and endotypes defining molecular mechanisms. Cytokines and chemokines released during infl…
View article: Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy
Analysis of the Serum Profile of Cytokines Involved in the T-Helper Cell Type 17 Immune Response Pathway in Atopic Children with Food Allergy Open
The main risk factor for the development of food allergies (FAs) in children is atopic dermatitis (AD). AD is usually recognized as the Th1/Th2 paradigm of allergic disease. Recently, the Th1/Th2 paradigm in allergy and autoimmunity has be…
View article: Host-dependent clinical risk factors and inflammatory cytokine levels as predictive markers of respiratory syncytial virus bronchiolitis in infants
Host-dependent clinical risk factors and inflammatory cytokine levels as predictive markers of respiratory syncytial virus bronchiolitis in infants Open
Purpose: Respiratory syncytial virus (RSV) is responsible for most cases of acute bronchiolitis in infants that require hospitalization. The infection is modulated by the local inflammatory response of the immune system via the production …
View article: Spontaneous pneumomediastinum – a rare cause of chest pain and dyspnoe in children
Spontaneous pneumomediastinum – a rare cause of chest pain and dyspnoe in children Open
Introduction. Spontaneous pneumomediastinum is a very rare condition in children. Nevertheless it should be considered in the differential diagnosis in patients who present with chest pain and dyspnoe.Aim. The aim of our study was to descr…
View article: Nitric Oxide Synthase 2 Promoter Polymorphism Is a Risk Factor for Allergic Asthma in Children
Nitric Oxide Synthase 2 Promoter Polymorphism Is a Risk Factor for Allergic Asthma in Children Open
Background and Objectives: In paediatric population, atopic asthma is associated with increased eosinophil counts in patients, that correlate with the airway inflammation measured by the concentration of nitric oxide in exhaled air (FeNO).…
View article: New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors
New Biomarkers of Hymenoptera Venom Allergy in a Group of Inflammation Factors Open
Hymenoptera venom allergy significantly affects the quality of life. Due to the divergences in the results of the available test and clinical symptoms of patients, the current widely applied diagnostic methods are often insufficient to cla…
View article: Decreased miRNA-320e correlates with allergy in children with otitis media with effusion
Decreased miRNA-320e correlates with allergy in children with otitis media with effusion Open
MiRNA expression differs between children with and without allergy in the course of OME, but further studies are needed to explain the exact role of miR-320e and its target genes in OME pathology in allergic patients.
View article: Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis
Expression of proteins associated with airway fibrosis differs between children with allergic asthma and allergic rhinitis Open
Allergic rhinitis (AR) and allergic asthma (AA) exhibit similar inflammatory response in the airways. However, the remodelling is more extensive in the lower airways, suggesting that the inflammation itself is not sufficient for allergic p…
View article: Interstitial lung disease and bronchiectasis in children with primary immunodeficiencies: a single-centre experience
Interstitial lung disease and bronchiectasis in children with primary immunodeficiencies: a single-centre experience Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA TÄ polska-Jóźwiak K, SzczawiÅska-PopÅonyk A, BrÄborowicz A. Interstitial lung disease and bronchiectasis in children with primary immunodeficiencies: a …
View article: Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma
Alterations in Serum-Free Amino Acid Profiles in Childhood Asthma Open
Asthma often begins in childhood, although making an early diagnosis is difficult. Clinical manifestations, the exclusion of other causes of bronchial obstruction, and responsiveness to anti-inflammatory therapy are the main tool of diagno…
View article: MiRNA Expression Profile in the Airways Is Altered during Pulmonary Exacerbation in Children with Cystic Fibrosis—A Preliminary Report
MiRNA Expression Profile in the Airways Is Altered during Pulmonary Exacerbation in Children with Cystic Fibrosis—A Preliminary Report Open
MicroRNAs are small non-coding RNAs that regulate immune response and inflammation. We assumed that miRNAs may be involved in the immune response during cystic fibrosis pulmonary exacerbations (CFPE) and that altered expression profile in …
View article: Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma
Neuroinflammatory Gene Expression Pattern Is Similar between Allergic Rhinitis and Atopic Dermatitis but Distinct from Atopic Asthma Open
Background and Aim . Neurogenic inflammation underlies the pathogenesis of allergic diseases. Interactions between neurons with the immune cells and structural cells (airway epithelium, nasal mucosa, skin keratinocytes) undergo altered reg…
View article: Factors causing oral and skin pathological featuresin the hyperimmunoglobulin E syndrome patient including the environmental component: a review of the literature and own experience
Factors causing oral and skin pathological featuresin the hyperimmunoglobulin E syndrome patient including the environmental component: a review of the literature and own experience Open
The hyperimmunoglobulin E syndrome (HIES) is a rare multi-system disease with non-immunological as well as immunological abnormalities. The syndrome is characterized by a triad of the most distinctive symptoms, such as pneumonia with pneum…
View article: Position statement of expert panel of the Polish Allergology Society on the management of patients with bronchial asthma and allergic diseases during SARS-Cov-2 pandemics
Position statement of expert panel of the Polish Allergology Society on the management of patients with bronchial asthma and allergic diseases during SARS-Cov-2 pandemics Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kowalski M, Bartuzi Z, Bręborowicz A, et al. Position statement of expert panel of the Polish Allergology Society on the management of patients with bronchia…
View article: Position statement of expert panel of the Polish Allergology Sociey on the management of patients with bronchial asthma and allergic diseases during SARS-Cov-2 pandemics. Update 1.06.2020
Position statement of expert panel of the Polish Allergology Sociey on the management of patients with bronchial asthma and allergic diseases during SARS-Cov-2 pandemics. Update 1.06.2020 Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Kowalski M, Bartuzi Z, Breborowicz A, et al. Position statement of expert panel of the Polish Allergology Sociey on the management of patients with bronchial…
View article: Cutaneous and systemic granulomatosisin ataxia-telangiectasia: a clinico-pathological study
Cutaneous and systemic granulomatosisin ataxia-telangiectasia: a clinico-pathological study Open
In the setting of combined immunodeficiency in A-T, cutaneous and systemic granulomatosis reflects a granulomatous reaction pattern, as a result of inappropriate immune regulation.
View article: Acute Subglottic Laryngitis. Etiology, Epidemiology, Pathogenesis and Clinical Picture
Acute Subglottic Laryngitis. Etiology, Epidemiology, Pathogenesis and Clinical Picture Open
In about 3% of children, viral infections of the airways that develop in early childhood lead to narrowing of the laryngeal lumen in the subglottic region resulting in symptoms such as hoarseness, abarking cough, stridor, and dyspnea. Thes…
View article: Evaluation of Copeptin during Pulmonary Exacerbation in Cystic Fibrosis
Evaluation of Copeptin during Pulmonary Exacerbation in Cystic Fibrosis Open
Copeptin was found to be a stable biomarker of inflammation and stress response in cardiac, renal, metabolic, and respiratory conditions such as pneumonia. The aim of this study was to investigate the copeptin levels in biological fluids (…
View article: The accuracy of lung auscultation in the practice of physicians and medical students
The accuracy of lung auscultation in the practice of physicians and medical students Open
These results confirm that ambiguous identification and interpretation of sounds in auscultation is a generic issue which should not be neglected as it can potentially lead to inaccurate diagnosis and mistreatment. Our results lend further…
View article: Practical implementation of artificial intelligence algorithms in pulmonary auscultation examination
Practical implementation of artificial intelligence algorithms in pulmonary auscultation examination Open
Lung auscultation is an important part of a physical examination. However, its biggest drawback is its subjectivity. The results depend on the experience and ability of the doctor to perceive and distinguish pathologies in sounds heard via…
View article: RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season
RSV versus non-RSV bronchiolitis in infants and young children – the bedside characteristics of one epidemic season Open
ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Szczawińska-Popłonyk A, Komasińska P, Tąpolska-Jóźwiak K, Więckowska B, Bręborowicz A. RSV versus non-RSV bronchiolitis in infants and young children – the b…