Anna Buigues
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View article: O-013 Intraovarian treatment with a specific combination of stem cell-secreted factors reactivates ovarian function in a premature ovarian insufficiency (POI) mouse model
O-013 Intraovarian treatment with a specific combination of stem cell-secreted factors reactivates ovarian function in a premature ovarian insufficiency (POI) mouse model Open
Study question Does a combination of thrombospondin 1 (THBS1), kit ligand (KITLG), and fibroblast growth factor 2 (FGF2) promote ovarian function in a POI mouse model? Summary answer Two consecutive intraovarian injections of THBS1, KITLG,…
View article: P-715 Effects of repeated platelet-rich plasma (PRP) injections for fertility recovery in a mouse model of premature ovarian insufficiency (POI)
P-715 Effects of repeated platelet-rich plasma (PRP) injections for fertility recovery in a mouse model of premature ovarian insufficiency (POI) Open
Study question Can multiple intraovarian injections of platelet-rich plasma (PRP) enhance ovarian function and fertility outcomes in a mouse model of premature ovarian insufficiency (POI)? Summary answer A double administration of PRP amel…
View article: Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models
Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models Open
Premature ovarian insufficiency (POI) means menopause before 40 years of age affecting about 1 % of women. Approaches based on cell therapy and the paracrine effects of stem cells or bioproducts such as platelet-rich plasma have been propo…
View article: P-255 Nicotinamide mononucleotide (NMN) supplementation during germinal vesicle (GV) rescue could increase the total number of mature oocytes available in women of advanced maternal age (AMA)
P-255 Nicotinamide mononucleotide (NMN) supplementation during germinal vesicle (GV) rescue could increase the total number of mature oocytes available in women of advanced maternal age (AMA) Open
Study question Does NMN supplementation improve nuclear and cytoplasmic competence of AMA oocytes during GV-rescue? Summary answer NMN supplementation enhances GV-rescue efficiency in AMA oocytes by improving nuclear competence and slightl…
View article: P-629 In vivo follicular activation (IVFA) through repeated ovarian punction: results of an experimental study in a premature ovarian insufficiency rodent model
P-629 In vivo follicular activation (IVFA) through repeated ovarian punction: results of an experimental study in a premature ovarian insufficiency rodent model Open
Study question Can the new IVFA therapy effectively promote ovarian follicle development and increase oocyte number in a premature ovarian insufficiency (POI) animal model. Summary answer The IVFA technique reveals favourable reproductive …
View article: P-791 The 4-step ASCOT technique modifies the plasma proteome of patients with premature ovarian insufficiency to resemble that of normoresponder women
P-791 The 4-step ASCOT technique modifies the plasma proteome of patients with premature ovarian insufficiency to resemble that of normoresponder women Open
Study question Does the 4-step ASCOT technique induce any modification in the plasma proteomic profile of women with premature ovarian insufficiency (POI)? Summary answer The 4-step ASCOT technique elicits substantial changes in plasma pro…
View article: P-604 Underlying molecular mechanisms of Polycystic Ovary Syndrome and Morphology: focusing on the ovary
P-604 Underlying molecular mechanisms of Polycystic Ovary Syndrome and Morphology: focusing on the ovary Open
Study question What mechanisms are involved in the ovarian alterations of Polycystic Ovary Syndrome (PCOS) and Morphology? Summary answer PCOS patients associated a distinctive impairment of oxidative phosphorylation and dysregulated compl…
View article: Systemic changes induced by autologous stem cell ovarian transplant in plasma proteome of women with impaired ovarian reserves
Systemic changes induced by autologous stem cell ovarian transplant in plasma proteome of women with impaired ovarian reserves Open
Patients with poor ovarian response (POR) and premature ovarian insufficiency (POI) are challenging to treat, with oocyte donation remaining as the only feasible option to achieve pregnancy in some cases. The Autologous stem cell ovarian t…
View article: Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes
Deciphering reproductive aging in women using a NOD/SCID mouse model for distinct physiological ovarian phenotypes Open
Female fertility is negatively correlated with age, with noticeable declines in oocyte quantity and quality until menopause. To understand this physiological process and evaluate human approaches for treating age-related infertility, precl…
View article: P-647 Underlying mechanisms in clinical manifestations of polycystic ovarian morphology (PCOM) and PCOS women
P-647 Underlying mechanisms in clinical manifestations of polycystic ovarian morphology (PCOM) and PCOS women Open
Study question Does the D19S884 allele 8 (A8) equally affect the pathogenesis and ovarian gene expression of PCOS and PCOM patients? Summary answer A8-allele produces metabolic, endocrine, and ovarian alterations regardless diagnose. The m…
View article: The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model
The cyto-protective effects of LH on ovarian reserve and female fertility during exposure to gonadotoxic alkylating agents in an adult mouse model Open
STUDY QUESTION Does LH protect mouse oocytes and female fertility from alkylating chemotherapy? SUMMARY ANSWER LH treatment before and during chemotherapy prevents detrimental effects on follicles and reproductive lifespan. WHAT IS KNOWN A…
View article: Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model†
Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model† Open
To analyze the role of PAI-1 (plasminogen activator inhibitor 1) in endometriotic lesion growth, we studied the effect of PAI-1 inhibition by PAI-039 using a homologous mouse model of endometriosis that allows noninvasive monitoring. Endom…
View article: A novel homologous model for noninvasive monitoring of endometriosis progression†
A novel homologous model for noninvasive monitoring of endometriosis progression† Open
To date, several groups have generated homologous models of endometriosis through the implantation of endometrial tissue fluorescently labeled by green fluorescent protein (GFP) or tissue from luciferase-expressing transgenic mice into rec…