Explanipedia

EXTH-138. GD2 as an Immunotherapeutic Target in Oligodendroglioma: Preclinical Evidence Supporting CAR T Cell Therapy Open

Kun-Wei Song, Vrunda Trivedi, Anna C. Geraghty, Gabriel Otubu, Yoon Seok Kim , et al. · 2025

BACKGROUND Oligodendrogliomas are a distinct subtype of diffuse gliomas that arise from glial cells resembling oligodendrocytes. While associated with a relatively favorable prognosis compared to other diffuse gliomas, oligodendrogliomas a…

CNSC-68. LEVETIRACETAM THERAPEUTICALLY TARGETS GABAERGIC SYNAPSES IN DIFFUSE MIDLINE GLIOMA Open

Tara Barron, Belgin Yalçın, Richard Drexler, Evan Cantor, Youkyeong Gloria Byun , et al. · 2025

Pediatric high-grade gliomas (HGGs) are the leading cause of brain cancer-related death in children. HGGs include distinct subtypes defined by anatomical location as well as molecular characteristics that stratify into H3K27M-altered diffu…

CNSC-72. ADRENERGIC NEURONS OF THE LOCUS COERULEUS PROMOTE DIFFUSE MIDLINE GLIOMA GROWTH Open

Youkyeong Gloria Byun, Yoon Seok Kim, Avishai Gavish, Tara Barron, Nadya Andini , et al. · 2025

H3K27M-altered diffuse midline glioma (DMG) is a highly aggressive childhood brain cancer occurring in the pons, thalamus, and spinal cord. In the DMG microenvironment, glutamatergic, GABAergic, and cholinergic neurons play critical roles …

Neuroligin-3 interaction with CSPG4 regulates normal and malignant glial precursors through PIEZO1 Open

Shawn Gillespie, Yoon Seok Kim, Anna C. Geraghty, Belgin Yalçın, Rebecca Mancusi , et al. · 2025

Glioma pathophysiology is robustly regulated by interactions with neurons. Key to these interactions is the role of neuroligin-3 (NLGN3), a synaptic adhesion molecule shed in response to neuronal activity 1–5 that functions as a paracrine …

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice Open

Anna C. Geraghty, Lehi Acosta-Alvarez, Maria Caterina Rotiroti, Selena Dutton, Michael R. O’Dea , et al. · 2025

Immunotherapies have revolutionized cancer care for many tumor types, but their potential long-term cognitive impacts are incompletely understood. Here, we demonstrated in mouse models that chimeric antigen receptor (CAR) T cell therapy fo…

GABAergic neuron-to-glioma synapses in diffuse midline gliomas Open

Tara Barron, Belgin Yalçın, Minhui Su, Youkyeong Gloria Byun, Avishai Gavish , et al. · 2025

Immunotherapy-related cognitive impairment after CAR T cell therapy in mice Open

Anna C. Geraghty, Lehi Acosta-Alvarez, Maria Caterina Rotiroti, Selena Dutton, Michael R. O’Dea , et al. · 2024

Summary Persistent central nervous system (CNS) immune dysregulation and consequent dysfunction of multiple neural cell types is central to the neurobiological underpinnings of a cognitive impairment syndrome that can occur following tradi…

Glioma synapses recruit mechanisms of adaptive plasticity Open

Kathryn R. Taylor, Tara Barron, Alexa Hui, Avishay Spitzer, Belgin Yalçın , et al. · 2023

Distinguishing features of long COVID identified through immune profiling Open

Jon Klein, Jamie Wood, Jillian R. Jaycox, Rahul M. Dhodapkar, Peiwen Lu , et al. · 2023

Post-acute infection syndromes may develop after acute viral disease 1 . Infection with SARS-CoV-2 can result in the development of a post-acute infection syndrome known as long COVID. Individuals with long COVID frequently report unremitt…

Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1 Open

Nathaniel W. Mabe, Min Huang, Guillermo Nicolás Dalton, Gabriela Alexe, Daniel A. Schaefer , et al. · 2022

Mild respiratory COVID can cause multi-lineage neural cell and myelin dysregulation Open

Anthony Fernández-Castañeda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung‐Hwa Lee , et al. · 2022

COVID survivors frequently experience lingering neurological symptoms that resemble cancer-therapy-related cognitive impairment, a syndrome for which white matter microglial reactivity and consequent neural dysregulation is central. Here, …

GD2-CAR T cell therapy for H3K27M-mutated diffuse midline gliomas Open

Robbie G. Majzner, Sneha Ramakrishna, Kristen W. Yeom, Shabnum Patel, Harshini Chinnasamy , et al. · 2022

Diffuse intrinsic pontine glioma (DIPG) and other H3K27M-mutated diffuse midline gliomas (DMGs) are universally lethal paediatric tumours of the central nervous system 1 . We have previously shown that the disialoganglioside GD2 is highly …

Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication Open

Johanna Theruvath, Marie Ménard, Benjamin Smith, Miles H. Linde, Garry L. Coles , et al. · 2022

TAMI-28. IDENTIFICATION OF A NEUROLIGIN-3 BINDING PARTNER IN HIGH-GRADE GLIOMAS AND NORMAL PROGENITORS Open

Shawn Gillespie, Yoon Seok Kim, Anna C. Geraghty, Michael A. Quezada, James Reed , et al. · 2021

High-grade gliomas, including diffuse intrinsic pontine glioma, are lethal cancers whose progression is strongly regulated by neuronal activity. One way in which gliomas detect neuronal activity is via interaction with the ectodomain of po…

HGG-05. NEURONAL ACTIVITY PROMOTES PEDIATRIC HIGH-GRADE GLIOMA GROWTH THROUGH A NLGN3-CSPG4 SIGNALING AXIS Open

Shawn Gillespie, Yoon Kim, Anna C. Geraghty, Pamelyn J. Woo, Michelle Monje · 2021

High-grade gliomas, including diffuse intrinsic pontine glioma (DIPG), are a lethal group of cancers whose progression is strongly regulated by neuronal activity {Venkatesh 2015}{Venkatesh 2017}{Venkatesh 2019}. One way in which glioma cel…

Therapeutic strategies for diffuse midline glioma from high-throughput combination drug screening Open

Grant L. Lin, Kelli M. Wilson, Michele Ceribelli, Benjamin Z. Stanton, Pamelyn J. Woo , et al. · 2019

High-throughput screens in DMG identify promising treatments, such as the combination of panobinostat and marizomib acting through metabolic collapse.

Disruption of Oligodendrogenesis Impairs Memory Consolidation in Adult Mice Open

Patrick E. Steadman, Frances Xia, Moriam Ahmed, Andrew J. Mocle, Amber Penning , et al. · 2019

TMIC-18. ELECTRICAL CIRCUIT INTEGRATION OF GLIOMA THROUGH NEURON-GLIOMA SYNAPSES AND POTASSIUM CURRENTS Open

Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Dana Silverbush, Shawn Gillespie , et al. · 2019

High-grade gliomas are a lethal group of cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors into the tumor microenvironment represents part of the mechanism by which neuronal …

Electrical and synaptic integration of glioma into neural circuits Open

Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Dana Silverbush, Shawn Gillespie , et al. · 2019

Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment Open

Anna C. Geraghty, Erin M. Gibson, Reem Ghanem, Jacob J. Greene, Alfonso Ocampo , et al. · 2019

DIPG-21. ELECTRICAL INTEGRATION OF GLIOMA INTO NEURAL CIRCUITRY Open

Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Dana Silverbush, Marlene Arzt , et al. · 2019

Pediatric high-grade gliomas (pHGGs) are a lethal group of cancers whose progression is robustly regulated by neuronal activity. Activity-regulated release of growth factors into the tumor microenvironment represents part of the mechanism …

BSTM-04. NEURONAL-ACTIVITY SECRETED BDNF INCREASES DIPG PROLIFERATION. Open

Kathryn Taylor, Razina Aziz‐Bose, Ariane Blank, Anna C. Geraghty, Michelle Monje · 2019

Pediatric high-grade gliomas (pHGG) are a devastating group of diseases that critically require novel therapeutic options. We have previously demonstrated that pHGG hijacks mechanisms of brain development and plasticity to their advantage.…

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-Related Cognitive Impairment Open

Erin M. Gibson, Surya Nagaraja, Alfonso Ocampo, Lydia Tam, Lauren Wood , et al. · 2018

TMIC-09. EXCITATORY SYNAPSES BETWEEN PRESYNAPTIC NEURONS AND POSTSYNAPTIC GLIOMA CELLS PROMOTE GLIOMA PROGRESSION Open

Humsa S. Venkatesh, Wade Morishita, Anna C. Geraghty, Lydia Tam, Dana Silverbush , et al. · 2018

Neuronal activity robustly regulates high-grade glioma growth. Here, we report that neuron-glioma interactions include bona fide synaptic communication. Glioma cell expression of synapse-related genes was confirmed at the single cell level…

DIPG-52. ACTIVE CHROMATIN IN H3K27M DIPG REVEALS DISTINCT EPIGENETIC SUBTYPES AND SUBTYPE-SPECIFIC MECHANISMS OF PATHOGENESIS Open

Surya Nagaraja, Michael A. Quezada, Shawn Gillespie, Anna C. Geraghty, Volker Hovestadt , et al. · 2018

DIPG is the leading cause of pediatric brain tumor-related death and remains without effective clinical treatment. Through numerous genomic studies, the H3K27M mutation has emerged as the molecular hallmark of DIPG. While this mutation cau…

DIPG-03. EXCITATORY SYNAPSES BETWEEN PRESYNAPTIC NEURONS AND POSTSYNAPTIC GLIOMA CELLS PROMOTE DIPG PROGRESSION Open

Humsa S. Venkatesh, Anna C. Geraghty, Wade Morishita, Lydia Tam, Itay Tirosh , et al. · 2018

High-grade gliomas represent the leading cause of brain tumor-associated death in children. We have recently discovered that active neurons robustly regulate glioma growth through activity-regulated secreted factors that critically include…

Tri-glial dysregulation in methotrexate chemotherapy-induced cognitive impairment Open

Erin M. Gibson, Surya Nagaraja, Alfonso Ocampo, Lydia Tam, Praveen N. Pallegar , et al. · 2018

Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persiste…

Neural Versus Gonadal GnIH: Are they Independent Systems? A Mini-Review Open

George E. Bentley, Kathryn Wilsterman, Darcy K. Ernst, Sharon E. Lynn, Molly J. Dickens , et al. · 2017

Based on research in protochordates and basal vertebrates, we know that communication across the first endocrine axes likely relied on diffusion. Because diffusion is relatively slow, rapid responses to some cues, including stress-related …

HGG-20. NEURONAL ACTIVITY PROMOTES PEDIATRIC GLIOMA INVASION Open

Tessa Johung, Kathryn R. Taylor, Humsa S. Venkatesh, Anna C. Geraghty, Michelle Monje · 2017

The diffusely infiltrating nature of pediatric high-grade glioma (pHGG) is a characteristic hallmark of this disease and represents a major contributor to the dire prognosis seen for pHGG of all neuroanatomical locations, most notably in H…

Patterns of hypothalamic GnIH change over the reproductive period in starlings and rats Open

Rebecca M. Calisi, Anna C. Geraghty, A. Avila, Daniela Kaufer, G. Bentley , et al. · 2016

Gonadotropin inhibitory hormone (GnIH) exerts powerful inhibitory effects on various levels of the vertebrate hypothalamic-pituitary-gonadal (reproductive) axis, yet little is known of how it might change naturally over the course of repro…

Anna C. Geraghty YOU? Author Swipe