Anna C. Smith
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View article: Lower amyloid and small vessel disease in unimpaired older adults with Down syndrome
Lower amyloid and small vessel disease in unimpaired older adults with Down syndrome Open
Background The revised Alzheimer's Association Research Framework presumes that all adults with Down syndrome (DS) are on the Alzheimer's disease (AD) continuum, developing AD at a median age of 54 years old after lifelong overproduction o…
View article: Microglia density measured by TSPO PET across amyloid positivity and clinical variants
Microglia density measured by TSPO PET across amyloid positivity and clinical variants Open
Background We hypothesized that TSPO PET, which measures microglia density, would be elevated in the presence of amyloid and impairment across different clinical variants in a pattern that follows their characteristic tau distribution. Met…
View article: Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials
Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials Open
Background Adults with Down syndrome (DS) overproduce amyloid precursor protein, develop amyloid plaques at an early age, and are diagnosed with Alzheimer’s disease (AD) dementia at a high frequency. There is emerging evidence that cerebro…
View article: The Impact of Diet on AD Biomarkers in a Community‐Based Sample
The Impact of Diet on AD Biomarkers in a Community‐Based Sample Open
Background Greater adherence to the Mediterranean Diet (MeDi) is associated with lower risk for cardiovascular disease, slower cognitive decline, and reduced risk for Alzheimer’s Disease (AD). However, its association with AD biomarkers is…
View article: Differential association of moderate alcohol use with neurodegeneration, cerebrovascular disease, and cognition by racial, ethnic and sex/gender groups in middle age
Differential association of moderate alcohol use with neurodegeneration, cerebrovascular disease, and cognition by racial, ethnic and sex/gender groups in middle age Open
Background Moderate alcohol use may be associated with brain and cognitive benefits compared to heavy alcohol use. However, results have varied. We hypothesized that the relationship between alcohol use and cognition is mediated by neurode…
View article: Differential association of moderate alcohol use with neurodegeneration, cerebrovascular disease, and cognition by racial, ethnic and sex/gender groups in middle age
Differential association of moderate alcohol use with neurodegeneration, cerebrovascular disease, and cognition by racial, ethnic and sex/gender groups in middle age Open
Background Moderate alcohol use may be associated with brain and cognitive benefits compared to heavy alcohol use. However, results have varied. We hypothesized that the relationship between alcohol use and cognition is mediated by neurode…
View article: Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials
Longitudinal changes in neuroimaging markers of small vessel disease: Implications for clinical trials Open
Background Adults with Down syndrome (DS) overproduce amyloid precursor protein, develop amyloid plaques at an early age, and are diagnosed with Alzheimer’s disease (AD) dementia at a high frequency. There is emerging evidence that cerebro…
View article: The Impact of Diet on AD Biomarkers in a Community‐Based Sample
The Impact of Diet on AD Biomarkers in a Community‐Based Sample Open
Background Greater adherence to the Mediterranean Diet (MeDi) is associated with lower risk for cardiovascular disease, slower cognitive decline, and reduced risk for Alzheimer’s Disease (AD). However, its association with AD biomarkers is…
View article: Psychotic symptoms are associated with elevated tau PET signal in the amygdala independent of Alzheimer’s disease clinical severity and amyloid burden
Psychotic symptoms are associated with elevated tau PET signal in the amygdala independent of Alzheimer’s disease clinical severity and amyloid burden Open
Background Psychosis in Alzheimer’s disease (AD) is associated with worse outcomes, yet no established biomarkers exist for early diagnosis and intervention. We compared tau PET burden across older individuals with and without psychotic sy…
View article: Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis
Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis Open
Background Psychosis is a debilitating cluster of symptoms occurring in some Alzheimer’s Disease (AD) patients, and is defined by the presence of delusions and/or hallucinations. Previous studies suggest that psychosis in AD patients is as…
View article: Discovering correlates of off‐target 18F‐MK6240 signal in community‐dwelling adults
Discovering correlates of off‐target 18F‐MK6240 signal in community‐dwelling adults Open
Background 18F‐MK6240 binds hyperphosphorylated tau protein in neurofibrillary tangles, a hallmark of Alzheimer’s disease(AD); however, the tracer may also bind to other similarly structured molecules, known as off‐target binding. Off‐targ…
View article: Pseudo‐longitudinal trajectories of cerebrovascular disease biomarkers in adults with Down syndrome across the lifespan
Pseudo‐longitudinal trajectories of cerebrovascular disease biomarkers in adults with Down syndrome across the lifespan Open
Background Adults with Down syndrome (DS) overproduce amyloid precursor protein, develop amyloid plaques at an early age, and are diagnosed with Alzheimer’s disease (AD) dementia at a high frequency. There is emerging evidence that cerebro…
View article: Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle‐aged adults
Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle‐aged adults Open
Background Moderate alcohol use may provide later life cognitive benefits compared to heavy alcohol use. However, results have been mixed, with reports of both increased and decreased gray and white matter volumes with moderate drinking. A…
View article: Validating noninvasive techniques for <sup>11</sup>C‐ER176 PET quantification in controls and Alzheimer’s disease patients
Validating noninvasive techniques for <sup>11</sup>C‐ER176 PET quantification in controls and Alzheimer’s disease patients Open
Background Noninvasive yet accurate PET quantification methods are crucial for safe yet meaningful PET studies. [ 11 C]ER176 is a PET radioligand that images neuroinflammation via the 18‐kDa translocator protein (TSPO), which is upregulate…
View article: Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle‐aged adults
Moderate alcohol use, total brain volume, and white matter hyperintensities among racially and ethnically diverse middle‐aged adults Open
Background Moderate alcohol use may provide later life cognitive benefits compared to heavy alcohol use. However, results have been mixed, with reports of both increased and decreased gray and white matter volumes with moderate drinking. A…
View article: Discovering correlates of off‐target 18F‐MK6240 signal in community‐dwelling adults
Discovering correlates of off‐target 18F‐MK6240 signal in community‐dwelling adults Open
Background 18F‐MK6240 binds hyperphosphorylated tau protein in neurofibrillary tangles, a hallmark of Alzheimer’s disease(AD); however, the tracer may also bind to other similarly structured molecules, known as off‐target binding. Off‐targ…
View article: Association of tau burden with sleep disordered breathing in adults with Down syndrome
Association of tau burden with sleep disordered breathing in adults with Down syndrome Open
Background Adults with Down syndrome (DS) overproduce the amyloid precursor protein and nearly all evidence clinical symptoms of Alzheimer’s Disease (AD) dementia in later life. Sleep disordered breathing, and specifically, obstructive sle…
View article: Pseudo‐longitudinal trajectories of cerebrovascular disease biomarkers in adults with Down syndrome across the lifespan
Pseudo‐longitudinal trajectories of cerebrovascular disease biomarkers in adults with Down syndrome across the lifespan Open
Background Adults with Down syndrome (DS) overproduce amyloid precursor protein, develop amyloid plaques at an early age, and are diagnosed with Alzheimer’s disease (AD) dementia at a high frequency. There is emerging evidence that cerebro…
View article: Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis
Elevated Tau burden in Amygdala and Hippocampus amongst older participants with psychosis Open
Background Psychosis is a debilitating cluster of symptoms occurring in some Alzheimer’s Disease (AD) patients, and is defined by the presence of delusions and/or hallucinations. Previous studies suggest that psychosis in AD patients is as…
View article: Validating noninvasive techniques for 11C‐ER176 PET quantification in controls and Alzheimer’s disease patients
Validating noninvasive techniques for 11C‐ER176 PET quantification in controls and Alzheimer’s disease patients Open
Background Noninvasive yet accurate PET quantification methods are crucial for safe yet meaningful PET studies. [11C]ER176 is a PET radioligand that images neuroinflammation via the 18‐kDa translocator protein (TSPO), which is upregulated …