Anna Carnes
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View article: The Physiological Association between Obstructive Sleep Apnea and Alzheimer’s Disease
The Physiological Association between Obstructive Sleep Apnea and Alzheimer’s Disease Open
Purpose of Review Alzheimer’s disease (AD) is multifactorial, and it is believed that several factors, including genetic, metabolic, bioenergetics, and environmental factors, have a role in the onset and development of this disease. Obstru…
View article: Can Personality Traits Affect Sleep Quality in Post-COVID-19 Patients?
Can Personality Traits Affect Sleep Quality in Post-COVID-19 Patients? Open
Objectives: In the present study, we aimed (i) to describe the personality traits of a cohort of post-COVID-19 condition (PCC) patients compared with a healthy control (HC) group, (ii) to evaluate the relationship between sleep quality and…
View article: Cognitive therapies and their impact on neuropsychiatric symptoms in mild cognitive impairment or dementia: a scoping review
Cognitive therapies and their impact on neuropsychiatric symptoms in mild cognitive impairment or dementia: a scoping review Open
To date, the impact of cognitive therapies on patients with dementia and mild cognitive impairment (MCI) has been studied in terms of cognition, quality of life and activities of daily living rather than in the context of neuropsychiatric …
View article: Cognition and objective sleep quality in post-COVID-19 patients
Cognition and objective sleep quality in post-COVID-19 patients Open
In the current study, we aimed (i) to evaluate sleep quality via wrist actigraphy monitoring of nonhospitalized and hospitalized post-COVID-19 condition (PCC) participants; (ii) to correlate actigraphy measures with subjective measures of …
View article: Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer’s Disease
Inflammatory and Redox Blood Gene Expression Fingerprint of Severe Obstructive Sleep Apnoea in Patients With Mild Alzheimer’s Disease Open
Our results show an upregulation of nine genes involved in NF-κB-mediated inflammation and redox metabolism in the blood of patients with mild AD with severe OSA. Therefore, severe OSA may worsen the inflammation and oxidative damage that …
View article: Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease
Sleep spindles and slow oscillations predict cognition and biomarkers of neurodegeneration in mild to moderate Alzheimer's disease Open
INTRODUCTION Changes in sleep physiology can predate cognitive symptoms by decades in persons with Alzheimer's disease (AD), but it remains unclear which sleep characteristics predict cognitive and neurodegenerative changes after AD onset.…
View article: Inflammatory and Redox Blood Gene Expression Fingerprint of Obstructive Sleep Apnoea in Patients with Alzheimer’s Disease
Inflammatory and Redox Blood Gene Expression Fingerprint of Obstructive Sleep Apnoea in Patients with Alzheimer’s Disease Open
Background Obstructive sleep apnoea (OSA) is the sleep disorder most frequently found in patients with Alzheimer’s disease (AD). The intermittent hypoxia (IH) caused by OSA may participate in AD pathogenesis through increase in oxidative d…
View article: Poor sleep quality as a potential trigger for cognitive deficits
Poor sleep quality as a potential trigger for cognitive deficits Open
Background In the present study we aimed to assess the cognition of post‐COVID condition (PCC) participants regarding their sleep quality, and to analyse different possible moderators of this effect, such as quality of life (European Quali…
View article: Poor sleep quality may trigger cognitive deficits after recovery from COVID-19
Poor sleep quality may trigger cognitive deficits after recovery from COVID-19 Open
Objective In the present study, we aimed to assess the cognition of post-COVID-19 condition (PCC) participants in relation to their subjective sleep quality (Pittsburgh Sleep Quality Index, PSQI) and to analyse possible moderators of this …
View article: Sleep quality in individuals with post-COVID-19 condition: Relation with emotional, cognitive and functional variables
Sleep quality in individuals with post-COVID-19 condition: Relation with emotional, cognitive and functional variables Open
The study aimed to assess sleep quality in PCC patients and its predictors by analysing its relationship with emotional, cognitive and functional variables, as well as possible differences based on COVID-19 severity. We included 368 indivi…
View article: Understanding the Episodic Memory and Executive Functioning Axis Impairment in MCI Patients: A Multicenter Study in Comparison with CSF Biomarkers
Understanding the Episodic Memory and Executive Functioning Axis Impairment in MCI Patients: A Multicenter Study in Comparison with CSF Biomarkers Open
Background: This study aimed to explore the association between a verbal learning task that evaluates the potential mutual dependency between memory and executive functions (i.e., the Test of Memory Strategies, TMS) and cerebrospinal fluid…
View article: Agreement of cerebrospinal fluid biomarkers and amyloid-PET in a multicenter study
Agreement of cerebrospinal fluid biomarkers and amyloid-PET in a multicenter study Open
Core Alzheimer’s disease (AD) cerebrospinal fluid (CSF) biomarkers have shown incomplete agreement with amyloid-positron emission tomography (PET). Our goal was to analyze the agreement between AD CSF biomarkers and amyloid-PET in a multic…
View article: Associations between memory strategies performance and CSF biomarkers: A new approach for the early intervention in MCI
Associations between memory strategies performance and CSF biomarkers: A new approach for the early intervention in MCI Open
Background Diagnostic research criteria for Alzheimer’s Disease (AD) recommend the cerebrospinal fluid (CSF) as a sensible and validated biomarker to improve the accuracy of the prognosis regarding progression to dementia for people with m…
View article: Cerebrospinal fluid neutral lipids are associated with Alzheimer’s disease progression
Cerebrospinal fluid neutral lipids are associated with Alzheimer’s disease progression Open
Background Genetic, metabolic, and clinical evidence links lipid dysregulation to an increased risk of Alzheimer’s disease (AD). However, the role of lipids in the pathophysiological processes of AD and its clinical progression is unclear.…
View article: COVID-19 severity is related to poor executive function in people with post-COVID conditions
COVID-19 severity is related to poor executive function in people with post-COVID conditions Open
Patients with post-coronavirus disease 2019 (COVID-19) conditions typically experience cognitive problems. Some studies have linked COVID-19 severity with long-term cognitive damage, while others did not observe such associations. This dis…
View article: Cerebrospinal Fluid Lipidomic Fingerprint of Obstructive Sleep Apnoea in Alzheimer’s Disease
Cerebrospinal Fluid Lipidomic Fingerprint of Obstructive Sleep Apnoea in Alzheimer’s Disease Open
Background: Obstructive sleep apnoea (OSA) has a high prevalence in patients with Alzheimer's disease (AD). Both conditions have been shown to be associated with lipid dysregulation. However, the relationship between OSA severity and alter…
View article: Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease
Changes in Plasma Neutral and Ether-Linked Lipids Are Associated with The Pathology and Progression of Alzheimer’s Disease Open
Aberrant lipid metabolism has been strongly linked to Alzheimer's disease (AD) pathogenesis. However, the role of lipids in the pathophysiological processes of AD and their clinical progression is unclear. We hypothesized that plasma lipid…
View article: Electrophysiological disruptions and cerebrospinal fluid biomarkers in mild cognitive impairment patients
Electrophysiological disruptions and cerebrospinal fluid biomarkers in mild cognitive impairment patients Open
Background Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized, at the neuropathological level, by the accumulation of amyloid‐β (Aβ) neuritic plaques and neurofibrillary tangles formed by hyperphosphorylated…
View article: Spanish-dementia knowledge assessment scale (DKAS-S): psychometric properties and validation
Spanish-dementia knowledge assessment scale (DKAS-S): psychometric properties and validation Open
Background Alzheimer’s disease (AD) is the most frequent cause of cognitive impairment. Community knowledge of the disease has proven to be a very important aspect of the development of interventions and the evaluation of their effectivene…
View article: Sleep profile predicts the cognitive decline of mild-moderate Alzheimer’s disease patients
Sleep profile predicts the cognitive decline of mild-moderate Alzheimer’s disease patients Open
Study Objectives To investigate the association between sleep and cognitive decline of patients with mild-moderate Alzheimer’s disease. Methods Observational, prospective study, including consecutive patients diagnosed with mild-moderate A…
View article: Additional file 1 of Spanish-dementia knowledge assessment scale (DKAS-S): psychometric properties and validation
Additional file 1 of Spanish-dementia knowledge assessment scale (DKAS-S): psychometric properties and validation Open
Additional file 1. Rowdata of the sample
View article: Plasmatic microRNA profile as biomarkers for the diagnosis of obstructive sleep apnea in Alzheimer’s disease patients
Plasmatic microRNA profile as biomarkers for the diagnosis of obstructive sleep apnea in Alzheimer’s disease patients Open
Background To investigate the potential of microRNAs (miRNAs) as biomarkers for the diagnosis of obstructive sleep apnea (OSA) in Alzheimer’s disease patients Method In this prospective, single‐center study (NCT02814045), patients were dia…
View article: Cognitive evolution of patients with mild Alzheimer’s disease can be predicted by circulatory microRNA expression profile
Cognitive evolution of patients with mild Alzheimer’s disease can be predicted by circulatory microRNA expression profile Open
Background To evaluate whether the expression profile of plasma microRNAs is able to predict the cognitive evolution of patients with early‐phase Alzheimer’s disease (AD). Method Through the Mini‐Mental State Examination (MMSE), we evaluat…
View article: Cognitive evolution of Alzheimer’s disease patients according to the serverity of obstructive sleep apnea
Cognitive evolution of Alzheimer’s disease patients according to the serverity of obstructive sleep apnea Open
Background To investigate the effect of OSA on the cognitive evolution of patients with AD. Method In this prospective, single‐center study (NCT02814045), patients with mild‐moderate AD with and without untreated OSA were evaluated at the …