Anna Caselli
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View article: EV-mediated asymmetrical crosstalk between CAFs and cancer cells in the tumor microenvironment
EV-mediated asymmetrical crosstalk between CAFs and cancer cells in the tumor microenvironment Open
Tumor is a complex tissue composed of both genetically transformed cancer cells and the cells of the tumor microenvironment, including connective cells, immune cells, and endothelial cells that actively contribute to the maintenance of the…
View article: Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia
Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia Open
View article: Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer
Targeting of tumor cells by custom antigen transfer: a novel approach for immunotherapy of cancer Open
In the early stages of carcinogenesis, the transformed cells become “invisible” to the immune system. From this moment on, the evolution of the tumor depends essentially on the genotype of the primitive cancer cells and their subsequent ge…
View article: Immunological Targeting of Tumor Cells: A Novel Approach
Immunological Targeting of Tumor Cells: A Novel Approach Open
View article: Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer
Therapy-Induced Stromal Senescence Promoting Aggressiveness of Prostate and Ovarian Cancer Open
Cancer progression is supported by the cross-talk between tumor cells and the surrounding stroma. In this context, senescent cells in the tumor microenvironment contribute to the development of a pro-inflammatory milieu and the acquisition…
View article: SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis
SHMT2-mediated mitochondrial serine metabolism drives 5-FU resistance by fueling nucleotide biosynthesis Open
View article: Differential impact of cold and hot tea extracts on tyrosine phosphatases regulating insulin receptor activity: a focus on PTP1B and LMW-PTP
Differential impact of cold and hot tea extracts on tyrosine phosphatases regulating insulin receptor activity: a focus on PTP1B and LMW-PTP Open
View article: Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs Open
Diabetes mellitus (DM) represents a group of metabolic disorders that leads to acute and long-term serious complications and is considered a worldwide sanitary emergence. Type 2 diabetes (T2D) represents about 90% of all cases of diabetes,…
View article: Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1
Activated fibroblasts enhance cancer cell migration by microvesicles-mediated transfer of Galectin-1 Open
Cancer-associated fibroblasts (CAFs) are one of the main components of the stromal compartment in the tumor microenvironment (TME) and the crosstalk between CAFs and cancer cells is essential for tumor progression and aggressiveness. Cance…
View article: S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset
S-Homocysteinylation effects on transthyretin: worsening of cardiomyopathy onset Open
View article: miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil
miR‐210‐3p mediates metabolic adaptation and sustains DNA damage repair of resistant colon cancer cells to treatment with 5‐fluorouracil Open
Chemoresistance is the primary cause of chemotherapy failure. Compelling evidence shows that micro RNAs (miRNAs) contribute to reprogram cancer cells toward a resistant phenotype. We investigate the role of miRNAs in the response to acute …
View article: Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells
Honey extracts inhibit PTP1B, upregulate insulin receptor expression, and enhance glucose uptake in human HepG2 cells Open
Honey is a food known for its medical properties. In this work, we have studied the impact of different types of honey on insulin signalling pathway. We found that honey extracts inhibit the enzyme PTP1B, one of the main negative regulator…
View article: LMW-PTP modulates glucose metabolism in cancer cells
LMW-PTP modulates glucose metabolism in cancer cells Open
View article: Targeting <scp>LMW</scp>‐<scp>PTP</scp> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy
Targeting <span>LMW</span>‐<span>PTP</span> to sensitize melanoma cancer cells toward chemo‐ and radiotherapy Open
Tumor resistance to apoptosis is one the main causes of anticancer treatment failure. Previous studies showed that LMW ‐ PTP overexpression enhances resistance of cancer cells to traditional anticancer drugs. Today, the role of LMW ‐ PTP i…
View article: Modeled Microgravity Affects Fibroblast Functions Related to Wound Healing
Modeled Microgravity Affects Fibroblast Functions Related to Wound Healing Open
View article: PAMP Activity of Cerato-Platanin during Plant Interaction: An -Omic Approach
PAMP Activity of Cerato-Platanin during Plant Interaction: An -Omic Approach Open
Cerato-platanin (CP) is the founder of a fungal protein family consisting in non-catalytic secreted proteins, which work as virulence factors and/or as elicitors of defense responses and systemic resistance, thus acting as PAMPs (pathogen-…
View article: Morin: A Promising Natural Drug
Morin: A Promising Natural Drug Open
Morin is a natural polyphenol, originally isolated from members of the Moraceae family that can be extracted from leaves, fruits, stems and branches of numerous plants. Several evidence have demonstrated that Morin could have a beneficial …
View article: 5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits
5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits Open
Despite marked tumor shrinkage after 5-FU treatment, the frequency of colon cancer relapse indicates that a fraction of tumor cells survives treatment causing tumor recurrence. The majority of cancer cells divert metabolites into anabolic …
View article: Comparative proteomic analysis of two distinct stem-cell populations from human amniotic fluid
Comparative proteomic analysis of two distinct stem-cell populations from human amniotic fluid Open
Characterization of two types of stem cells isolated from human amniotic fluid.