Anna Cattrell
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View article: Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study
Substance Use Initiation, Particularly Alcohol, in Drug-Naive Adolescents: Possible Predictors and Consequences From a Large Cohort Naturalistic Study Open
These results suggest that the transition from no use to frequent drinking in early to mid-adolescence may disrupt normative developmental changes in behavioral control. In addition, blunted activity of the medial orbitofrontal cortex duri…
View article: The IMAGEN study: a decade of imaging genetics in adolescents
The IMAGEN study: a decade of imaging genetics in adolescents Open
Imaging genetics offers the possibility of detecting associations between genotype and brain structure as well as function, with effect sizes potentially exceeding correlations between genotype and behavior. However, study results are ofte…
View article: Associations of sickness absence for pain in the low back, neck and shoulders with wider propensity to pain
Associations of sickness absence for pain in the low back, neck and shoulders with wider propensity to pain Open
Objectives To explore the association of sickness absence ascribed to pain at specific anatomical sites with wider propensity to musculoskeletal pain. Methods As part of the CUPID (Cultural and Psychosocial Influences on Disability) study,…
View article: Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence
Sex effects on structural maturation of the limbic system and outcomes on emotional regulation during adolescence Open
Though adolescence is a time of emerging sex differences in emotions, sex-related differences in the anatomy of the maturing brain has been under-explored over this period. The aim of this study was to investigate whether puberty and sexua…
View article: Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity
Heavy drinking in adolescents is associated with change in brainstem microstructure and reward sensitivity Open
The cortical‐cerebellar circuit is vulnerable to heavy drinking (HD) in adults. We hypothesized early microstructural modifications of the pons/midbrain region, containing core structures of the reward system, in HD adolescents. Thirty‐two…
View article: Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation
Pubertal maturation and sex effects on the default-mode network connectivity implicated in mood dysregulation Open
This study examines the effects of puberty and sex on the intrinsic functional connectivity (iFC) of brain networks, with a focus on the default-mode network (DMN). Consistently implicated in depressive disorders, the DMN’s function may in…
View article: Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression
Early Variations in White Matter Microstructure and Depression Outcome in Adolescents With Subthreshold Depression Open
Early FA variations in tracts projecting from the corpus callosum to the anterior cingulate cortex may denote a higher risk of transition to depression in adolescents.
View article: Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence
Modulation of orbitofrontal-striatal reward activity by dopaminergic functional polymorphisms contributes to a predisposition to alcohol misuse in early adolescence Open
Background Abnormalities in reward circuit function are considered a core feature of addiction. Yet, it is still largely unknown whether these abnormalities stem from chronic drug use, a genetic predisposition, or both. Methods In the pres…
View article: The initiation of cannabis use in adolescence is predicted by sex‐specific psychosocial and neurobiological features
The initiation of cannabis use in adolescence is predicted by sex‐specific psychosocial and neurobiological features Open
Cannabis use initiated during adolescence might precipitate negative consequences in adulthood. Thus, predicting adolescent cannabis use prior to any exposure will inform the aetiology of substance abuse by disentangling predictors from co…
View article: Drivers of international variation in prevalence of disabling low back pain: Findings from the Cultural and Psychosocial Influences on Disability study
Drivers of international variation in prevalence of disabling low back pain: Findings from the Cultural and Psychosocial Influences on Disability study Open
Background Wide international variation in the prevalence of disabling low back pain ( LBP ) among working populations is not explained by known risk factors. It would be useful to know whether the drivers of this variation are specific to…
View article: Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood
Ventromedial Prefrontal Volume in Adolescence Predicts Hyperactive/Inattentive Symptoms in Adulthood Open
Youths with attention-deficit/hyperactivity disorder symptomatology often exhibit residual inattention and/or hyperactivity in adulthood; however, this is not true for all individuals. We recently reported that dimensional, multi-informant…
View article: Methylation of <i> <scp>OPRL</scp> 1 </i> mediates the effect of psychosocial stress on binge drinking in adolescents
Methylation of <i> <span>OPRL</span> 1 </i> mediates the effect of psychosocial stress on binge drinking in adolescents Open
Background Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome‐wide methylation analysis, we recently identified an association of a methylated region in the OPRL 1 gene with alcohol‐use disorders. …
View article: Psychosocial Stress and Brain Function in Adolescent Psychopathology
Psychosocial Stress and Brain Function in Adolescent Psychopathology Open
The results link hyperactive amygdala responses and regions critical for top-down emotional processing with high levels of psychosocial stress in individuals with greater conduct and hyperactivity/inattention symptoms. This work highlights…
View article: Epidemiological Differences Between Localized and Nonlocalized Low Back Pain
Epidemiological Differences Between Localized and Nonlocalized Low Back Pain Open
Study Design. A cross-sectional survey with a longitudinal follow-up. Objectives. The aim of this study was to test the hypothesis that pain, which is localized to the low back, differs epidemiologically from that which occurs simultaneous…
View article: Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder
Ventral striatum and amygdala activity as convergence sites for early adversity and conduct disorder Open
Childhood family adversity (CFA) increases the risk for conduct disorder (CD) and has been associated with alterations in regions of affective processing like ventral striatum (VS) and amygdala. However, no study so far has demonstrated ne…
View article: Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents
Polygenic Risk of Psychosis and Ventral Striatal Activation During Reward Processing in Healthy Adolescents Open
These findings support an association between psychosis RPS and VS BOLD in adolescents. Genetic risk for psychosis may shape an individual's response to rewarding stimuli.
View article: Disentangling the autism−anxiety overlap: fMRI of reward processing in a community-based longitudinal study
Disentangling the autism−anxiety overlap: fMRI of reward processing in a community-based longitudinal study Open
Up to 40% of youth with autism spectrum disorder (ASD) also suffer from anxiety, and this comorbidity is linked with significant functional impairment. However, the mechanisms of this overlap are poorly understood. We investigated the inte…
View article: Descriptive Epidemiology of Somatising Tendency: Findings from the CUPID Study
Descriptive Epidemiology of Somatising Tendency: Findings from the CUPID Study Open
Somatising tendency, defined as a predisposition to worry about common somatic symptoms, is importantly associated with various aspects of health and health-related behaviour, including musculoskeletal pain and associated disability. To ex…
View article: Neural basis of reward anticipation and its genetic determinants
Neural basis of reward anticipation and its genetic determinants Open
Significance We characterize in humans a coordinated network of brain activity describing neurobehavioral correlates of reward anticipation. The network involves nodes in striatal and cortical brain regions, which are preferentially associ…
View article: Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers
Ventral Striatum Connectivity During Reward Anticipation in Adolescent Smokers Open
Substance misusers, including adolescent smokers, often have reduced reward system activity during processing of non-drug rewards. Using a psychophysiological interaction approach, we examined functional connectivity with the ventral stria…