Anna Cebula
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View article: Commensal epitopes drive differentiation of colonic T <sub>regs</sub>
Commensal epitopes drive differentiation of colonic T <sub>regs</sub> Open
Colonic commensal-derived antigens support expansion and differentiation of immunosupressive CD4 T cells.
View article: Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice
Dormant pathogenic CD4+ T cells are prevalent in the peripheral repertoire of healthy mice Open
Thymic central tolerance eliminates most immature T cells with autoreactive T cell receptors (TCR) that recognize self MHC/peptide complexes. Regardless, an unknown number of autoreactive CD4 + Foxp3 − T cells escape negative selection and…
View article: Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens
Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens Open
In the gut, various subsets of intraepithelial T cells (IELs) respond to self or non-self-antigens derived from the body, diet, commensal and pathogenic microbiota. Dominant subset of IELs in the small intestine are TCRαβCD8αα + cells, whi…