Averil Ma
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View article: A20 restriction of nitric oxide production restores macrophage bioenergetic balance
A20 restriction of nitric oxide production restores macrophage bioenergetic balance Open
Macrophages play critical roles in regulating host responses to microbial pathogens and other forms of tissue stress and can acquire pro-inflammatory or tissue reparative phenotypes. A20, or TNFAIP3, is a potent regulator of innate immune …
View article: Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy
Base-editing a single missense mutation in A20 enhances CAR-T cell efficacy Open
T cell exhaustion limits the efficacy of cancer immunotherapies. Here, we performed genome-wide loss-of-function screening in repetitively stimulated human T cells and identified the mulitfunctional ubiquitin-modifying protein A20/TNFAIP3 …
View article: Fibroblast orchestration of inflammaging via NF-kB activation
Fibroblast orchestration of inflammaging via NF-kB activation Open
Summary Aged tissue is characterized by chronic inflammation known as “inflammaging”. While this aging immune phenotype supposedly drives some of the most common diseases affecting the elderly, little is known about the structural drivers …
View article: A20’s linear ubiquitin–binding motif restrains pathogenic activation of Th17 cells and IL-22–driven enteritis
A20’s linear ubiquitin–binding motif restrains pathogenic activation of Th17 cells and IL-22–driven enteritis Open
A20, encoded by the TNFAIP3 gene, is a protein linked to Crohn's disease and celiac disease in humans. We now find that mice expressing point mutations in A20's M1-ubiquitin-binding zinc finger 7 (ZF7) motif spontaneously develop proximal …
View article: A New Mouse Model of Psoriatic Arthritis
A New Mouse Model of Psoriatic Arthritis Open
Polymorphisms in the TNFAIP3 locus encoding the A20 protein are strongly associated with psoriatic skin and joint disease. Reduced A20 expression, driven by both genetic and epigenetic factors, underscores its critical role as a negative r…
View article: Latent profile analysis of social participation among adults with cardiovascular disease based on the CHARLS
Latent profile analysis of social participation among adults with cardiovascular disease based on the CHARLS Open
Social participation is recognized as a critical factor in reducing mortality and promoting healthy aging in middle-aged and older adults with cardiovascular disease (CVD). However, the determinants influencing social participation within …
View article: Association of Serum Albumin-Bilirubin Score with Early Post-operative Complications Following Liver Resection
Association of Serum Albumin-Bilirubin Score with Early Post-operative Complications Following Liver Resection Open
Introduction: The Serum Albumin-Bilirubin (ALBI) score has emerged as a valuable tool for assessing liver function and predicting postoperative outcomes in patients undergoing liver resection. This study aims to explore the association bet…
View article: Rate And Grade of Postoperative Pancreatic Fistula After Modified Blumgart Pancreaticojejunostomy in Pancreaticoduodenectomy
Rate And Grade of Postoperative Pancreatic Fistula After Modified Blumgart Pancreaticojejunostomy in Pancreaticoduodenectomy Open
Introduction: Pancreaticoduodenectomy (PD), commonly known as the Whipple procedure, is the standard surgical approach for treating pancreatic and periampullary cancers. Despite advancements in surgical techniques, postoperative pancreatic…
View article: Association Of Serum Prothrombin Index With Early Post-Operative Complications Following Liver Resection
Association Of Serum Prothrombin Index With Early Post-Operative Complications Following Liver Resection Open
Introduction: The Prothrombin Index (PI) is a critical measure of coagulation status, reflecting the liver's ability to synthesize clotting factors. In the context of liver resection, a procedure associated with a significant risk of bleed…
View article: Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients
Sustained mucosal colonization and fecal metabolic dysfunction by Bacteroides associates with fecal microbial transplant failure in ulcerative colitis patients Open
Fecal microbial transplantation (FMT) offers promise for treating ulcerative colitis (UC), though the mechanisms underlying treatment failure are unknown. This study harnessed longitudinally collected colonic biopsies (n = 38) and fecal sa…
View article: A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny
A20 and the noncanonical NF-κB pathway are key regulators of neutrophil recruitment during fetal ontogeny Open
Newborns are at high risk of developing neonatal sepsis, particularly if born prematurely. This has been linked to divergent requirements the immune system has to fulfill during intrauterine compared with extrauterine life. By transcriptom…
View article: Intestinal inflammation alters the antigen-specific immune response to a skin commensal
Intestinal inflammation alters the antigen-specific immune response to a skin commensal Open
Resident microbes in skin and gut predominantly impact local immune cell function during homeostasis. However, colitis-associated neutrophilic skin disorders suggest possible breakdown of this compartmentalization with disease. Using a mod…
View article: Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase
Distinct phases of adult microglia proliferation: a Myc-mediated early phase and a Tnfaip3-mediated late phase Open
Microgliosis is a hallmark of many neurological diseases, including Alzheimer’s disease, stroke, seizure, traumatic brain and spinal cord injuries, and peripheral and optic nerve injuries. Recent studies have shown that the newly self-rene…
View article: Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage
Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage Open
Anti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously demonstrated that a…
View article: Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium
Microbial signals and lymphotoxin drive TNF-independent death of A20 and ABIN-1 deficient epithelium Open
Anti-TNF antibodies are effective for treating patients with inflammatory bowel disease (IBD), but many patients fail to respond to anti-TNF therapy, highlighting the importance of TNF-independent disease. We previously demonstrated that a…
View article: Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis
Strain-resolved analysis in a randomized trial of antibiotic pretreatment and maintenance dose delivery mode with fecal microbiota transplant for ulcerative colitis Open
Fecal microbiota transplant is a promising therapy for ulcerative colitis. Parameters maximizing effectiveness and tolerability are not yet clear, and it is not known how import the transmission of donor microbes to patients is. Here ( cli…
View article: Impact of Microdevice Geometry on Transit and Retention in the Murine Gastrointestinal Tract
Impact of Microdevice Geometry on Transit and Retention in the Murine Gastrointestinal Tract Open
Oral protein delivery technologies often depend on encapsulating or enclosing the protein cargo to protect it against pH-driven degradation in the stomach or enzymatic digestion in the small intestine. An emergent methodology is to encapsu…
View article: Direct, Noncatalytic Mechanism of IKK Inhibition by A20
Direct, Noncatalytic Mechanism of IKK Inhibition by A20 Open
A20 is a potent anti-inflammatory protein that inhibits NF-κB, and A20 dysfunction is associated with autoimmunity and B-cell lymphoma. A20 harbors a deubiquitination enzyme domain and can employ multiple mechanisms to antagonize ubiquitin…
View article: TNFAIP3 Plays a Role in Aging of the Hematopoietic System
TNFAIP3 Plays a Role in Aging of the Hematopoietic System Open
Hematopoietic stem and progenitor cells (HSPC) experience a functional decline in response to chronic inflammation or aging. Haploinsufficiency of A20, or TNFAIP3, an innate immune regulator, is associated with a variety of autoimmune, inf…
View article: Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer
Editorial: Modulating Cytokines as Treatment for Autoimmune Diseases and Cancer Open
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