Anna Conen
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View article: Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland ( <scp>FUNGINOS</scp> )
Management of Invasive Pulmonary Aspergillosis in Intensive Care Units: Guidelines From the Fungal Infection Network of Switzerland ( <span>FUNGINOS</span> ) Open
Invasive pulmonary aspergillosis (IPA) is increasingly recognised in intensive care units (ICU) affecting not only patients with classical immunosuppressive conditions but also other severely ill patients, including those with respiratory …
View article: Infective endocarditis and cardiac events after transcatheter vs surgical aortic valve replacement: A nationwide cohort study
Infective endocarditis and cardiac events after transcatheter vs surgical aortic valve replacement: A nationwide cohort study Open
For patients undergoing aortic valve replacement for native aortic valve stenosis, TAVI was associated with higher rates of IE than bioSAVR, as was bioSAVR when compared with mechSAVR.
View article: Update on prevention and antimicrobial prophylaxis of infective endocarditis
Update on prevention and antimicrobial prophylaxis of infective endocarditis Open
The Swiss expert group published revised guidelines on the prevention and antibiotic prophylaxis against infective endocarditis in 2021. In this viewpoint article, the group reports on their experiences two years after implementing the new…
View article: Gas gangrene with Clostridium septicum in a neutropenic patient
Gas gangrene with Clostridium septicum in a neutropenic patient Open
Gas gangrene is a rare presentation of a necrotizing fasciitis, caused by Clostridium perfringens, C. septicum and other clostridial species. With its rapid progression it is a potentially life-threatening infection, that poses as a challe…
View article: Isavuconazole for the Treatment of Fungal Infections: A Real-life Experience From the Fungal Infection Network of Switzerland (FUNGINOS)
Isavuconazole for the Treatment of Fungal Infections: A Real-life Experience From the Fungal Infection Network of Switzerland (FUNGINOS) Open
This analysis of 116 isavuconazole therapy courses shows that hepatic test disturbances (HTDs) were relatively frequent (29% of cases) but rarely led to treatment interruption (5%). Importantly, patients with baseline HTDs, including those…
View article: Burden of disease in patients hospitalised with COVID-19 during the first and second pandemic wave in Switzerland: a nationwide cohort study
Burden of disease in patients hospitalised with COVID-19 during the first and second pandemic wave in Switzerland: a nationwide cohort study Open
AIM OF THE STUDY: The first and second waves of the COVID-19 pandemic led to a tremendous burden of disease and influenced several policy directives, prevention and treatment strategies as well as lifestyle and social behaviours. We aimed …
View article: Antibiotic treatment durations for common infectious diseases in Switzerland: comparison between real-life and local and international guideline recommendations
Antibiotic treatment durations for common infectious diseases in Switzerland: comparison between real-life and local and international guideline recommendations Open
DAT exceeded recommendations in a significant proportion of patients with mostly community-acquired infections.
View article: Higher risk for influenza‐associated pulmonary aspergillosis (IAPA) in asthmatic patients: A Swiss multicenter cohort study on IAPA in critically ill influenza patients
Higher risk for influenza‐associated pulmonary aspergillosis (IAPA) in asthmatic patients: A Swiss multicenter cohort study on IAPA in critically ill influenza patients Open
Background Influenza‐associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality. Methods We conducted a retrospective multicenter study in tertiary hospitals in Switzerland …
View article: Higher risk for influenza-associated pulmonary aspergillosis (IAPA) in asthmatic patients. A Swiss multicenter cohort study on IAPA in critically ill influenza patients.
Higher risk for influenza-associated pulmonary aspergillosis (IAPA) in asthmatic patients. A Swiss multicenter cohort study on IAPA in critically ill influenza patients. Open
Background: Influenza-associated pulmonary aspergillosis (IAPA) is an important complication of severe influenza with high morbidity and mortality. Methods: We conducted a retrospective multicenter study in tertiary hospitals in Switzerlan…
View article: Prevalence of Micronutrient Deficiencies in Patients Hospitalized with COVID-19: An Observational Cohort Study
Prevalence of Micronutrient Deficiencies in Patients Hospitalized with COVID-19: An Observational Cohort Study Open
Background: A higher risk for severe clinical courses of coronavirus disease 2019 (COVID-19) has been linked to deficiencies of several micronutrients. We therefore studied the prevalence of deficiencies of eight different micronutrients i…
View article: Distribution of <i>Aspergillus</i> Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals
Distribution of <i>Aspergillus</i> Species and Prevalence of Azole Resistance in Respiratory Samples From Swiss Tertiary Care Hospitals Open
Among 400 Aspergillus species from respiratory samples in Switzerland, Aspergillus fumigatus was the most frequent species. Non-fumigatus Aspergillus spp were more prevalent among solid organ transplant recipients and after azole exposure.…
View article: Antibiotic prophylaxis with amoxicillin to prevent infective endocarditis in periodontitis patients reconsidered: a narrative review
Antibiotic prophylaxis with amoxicillin to prevent infective endocarditis in periodontitis patients reconsidered: a narrative review Open
OBJECTIVES: To discuss first, the adequacy of the antibiotic prophylaxis regimen currently recommended for the prevention of infective endocarditis in periodontitis patients, and second, preventive measures to decrease the rate of bacterae…
View article: Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey
Trends of the Epidemiology of Candidemia in Switzerland: A 15-Year FUNGINOS Survey Open
Background The increasing incidence of candidemia and emergence of drug-resistant Candida species are major concerns worldwide. Long-term surveillance studies are needed. Methods The Fungal Infection Network of Switzerland (FUNGINOS) condu…
View article: Comparison of characteristics, predictors and outcomes between the first and second COVID-19 waves in a tertiary care centre in Switzerland: an observational analysis
Comparison of characteristics, predictors and outcomes between the first and second COVID-19 waves in a tertiary care centre in Switzerland: an observational analysis Open
AIM OF THE STUDY To compare admission characteristics, predictors and outcomes of patients with confirmed coronavirus disease 2019 (COVID-19) hospitalised in a tertiary care hospital in Switzerland during the first and second waves of the …
View article: Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis
Association of endothelial activation assessed through endothelin-I precursor peptide measurement with mortality in COVID-19 patients: an observational analysis Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has been linked to thrombotic complications and endothelial dysfunction. We assessed the prognostic implications of endothelial activation through m…
View article: Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study
Activation of Vasopressin System During COVID-19 is Associated With Adverse Clinical Outcomes: An Observational Study Open
Background Activation of the vasopressin system plays a key role for the maintenance of osmotic, cardiovascular, and stress hormone homeostasis during disease. We investigated levels of copeptin, the C-terminal segment of the vasopressin p…
View article: Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study
Ophthalmic Screening in Patients with Coronavirus Disease 2019: A Prospective Cohort Study Open
Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce and conflicting. In our study, …
View article: Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19
Renin-angiotensin-aldosterone system peptide profiles in patients with COVID-19 Open
Objective While evidence on the interface between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and the renin-angiotensin-aldosterone-system (RAAS) is accumulating, clinical data on RAAS peptide alteration among co…
View article: A review of recommendations for infective endocarditis prevention in patients undergoing transcatheter aortic valve implantation
A review of recommendations for infective endocarditis prevention in patients undergoing transcatheter aortic valve implantation Open
Infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is a new disease entity. The rate of IE after TAVI is similar to that after surgical aortic valve replacement (SAVR), but mortality and prevalence of Enteroco…
View article: The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study
The vasoactive peptide MR-pro-adrenomedullin in COVID-19 patients: an observational study Open
Objectives Midregional pro-adrenomedullin (MR-proADM) is a vasoactive peptide with key roles in reducing vascular hyperpermeability and thereby improving endothelial stability during infection. While MR-proADM is useful for risk stratifica…
View article: Lung Assessment with Point-of-Care Ultrasound in Respiratory Coronavirus Disease (COVID-19): A Prospective Cohort Study
Lung Assessment with Point-of-Care Ultrasound in Respiratory Coronavirus Disease (COVID-19): A Prospective Cohort Study Open
Lung ultrasound (LUS) has shown promising diagnostic potential in different pulmonary conditions. We evaluated the diagnostic accuracy of LUS for pulmonary COVID-19. In this prospective cohort study at a Swiss tertiary care center, patient…
View article: Management of hepatitis C in opioid agonist therapy patients of the Swiss canton Aargau within and outside the cohort study
Management of hepatitis C in opioid agonist therapy patients of the Swiss canton Aargau within and outside the cohort study Open
BACKGROUND Hepatitis C virus (HCV) treatment reduces hepatic and extrahepatic morbidity and mortality and prevents further transmissions. Since October 2017, direct-acting antivirals (DAAs) have been reimbursed in Switzerland for all patie…