Anna Csala
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View article: Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents
Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents Open
mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Type I interferon (IFN-I) is an integral part of this …
View article: Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents
Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents Open
Introduction The key to understanding the COVID-19 correlates of protection is assessing vaccine-induced immunity in different demographic groups. Young people are at a lower risk of COVID-19 mortality, females are at a lower risk than mal…
View article: Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members
Cellular immunity to SARS-CoV-2 following intrafamilial exposure in seronegative family members Open
Introduction Family studies of antiviral immunity provide an opportunity to assess virus-specific immunity in infected and highly exposed individuals, as well as to examine the dynamics of viral infection within families. Transmission of S…
View article: Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents
Gonadal androgens are associated with decreased type I interferon production by pDCs and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents Open
mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted the need to better understand the interaction of adjuvants and the early innate immune response. Interferon type I (IFN-I) is an integral part of this …
View article: Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents
Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents Open
Key to understanding COVID-19 correlates of protection is assessing vaccine-induced immunity in different demographic groups. Sex- and age-specific immune differences have a wide impact on outcomes from infections and immunisations. Typica…
View article: Supplementary Material for: Frequency and functional consequences of low appendicular lean mass and sarcopenic obesity in patients with asthma referred for pulmonary rehabilitation
Supplementary Material for: Frequency and functional consequences of low appendicular lean mass and sarcopenic obesity in patients with asthma referred for pulmonary rehabilitation Open
Introduction: one of the most prominent extra-pulmonary manifestations in patients with chronic respiratory disease are changes in body weight and composition. However, the frequency and functional consequences of low appendicular lean mas…
View article: Supplementary Material for: Frequency and functional consequences of low appendicular lean mass and sarcopenic obesity in patients with asthma referred for pulmonary rehabilitation
Supplementary Material for: Frequency and functional consequences of low appendicular lean mass and sarcopenic obesity in patients with asthma referred for pulmonary rehabilitation Open
Introduction: one of the most prominent extra-pulmonary manifestations in patients with chronic respiratory disease are changes in body weight and composition. However, the frequency and functional consequences of low appendicular lean mas…
View article: Low Replication Capacity Virus is Preferentially Transmitted in Mother-to-Child-Transmission but not in Adult-to-Adult-Transmission of HIV-1
Low Replication Capacity Virus is Preferentially Transmitted in Mother-to-Child-Transmission but not in Adult-to-Adult-Transmission of HIV-1 Open
Previous studies of the transmitted/founder virus compared to viral quasispecies in the donor have yielded conflicting results. In heterosexual adult-to-adult transmission (ATAT), the viral replicative capacity (VRC) of transmitted virus i…
View article: Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia
Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia Open
These data are consistent with recovery of functional CD4 T-cell responses in ART-treated children, in contrast to relative lack of CD4 T-cell function recovery described in ART-treated adults. However, the challenges of achieving long-ter…
View article: Differential Immunodominance Hierarchy of CD8<sup>+</sup>T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection
Differential Immunodominance Hierarchy of CD8<sup>+</sup>T-Cell Responses in HLA-B*27:05- and -B*27:02-Mediated Control of HIV-1 Infection Open
The well-characterized association between HLA-B*27:05 and protection against HIV disease progression has been linked to immunodominant HLA-B*27:05-restricted CD8 + T-cell responses toward the conserved Gag KK10 (residues 263 to 272) and p…
View article: Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection
Nonprogressing HIV-infected children share fundamental immunological features of nonpathogenic SIV infection Open
Pediatric HIV patients who do not rapidly develop AIDS are shown to have immunological features similar to nonhuman primates that experience nonpathogenic SIV infection.
View article: Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection
Discordant Impact of HLA on Viral Replicative Capacity and Disease Progression in Pediatric and Adult HIV Infection Open
HLA class I polymorphism has a major influence on adult HIV disease progression. An important mechanism mediating this effect is the impact on viral replicative capacity (VRC) of the escape mutations selected in response to HLA-restricted …