Anna L. David
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View article: Low‐Field Magnetic Resonance Imaging of the Late Gestation Cervix and Birth Outcome Correlation: A Prospective Cohort Study
Low‐Field Magnetic Resonance Imaging of the Late Gestation Cervix and Birth Outcome Correlation: A Prospective Cohort Study Open
Objective To use low‐field MRI to produce reconstructions and 3D models of the cervix and to automate measurements for correlation with demographics and birth outcomes. Design Prospective cohort study. Setting KCL Advanced Imaging Centre, …
View article: Late gestation MRI to assess maternal pelvimetry, fetal biometry and placental oxygenation: a retrospective pilot study
Late gestation MRI to assess maternal pelvimetry, fetal biometry and placental oxygenation: a retrospective pilot study Open
Background The role of MRI pelvimetry and fetal size estimation in predicting mode of birth and risk of operative birth have been studied. However, there are no complete MRI studies that assess the maternal pelvis, fetal dimensions, and th…
View article: Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation
Triage and care for women with symptoms or diagnosis of pregnancy loss between 14 + 0 and 21 + 6 weeks' gestation Open
Mid‐trimester pregnancy loss (MTL), defined as a pregnancy loss occurring between 14 + 0 and 21 + 6 weeks of gestation, causes significant physical and emotional distress to women and presents clinical challenges to healthcare professional…
View article: Implementation of the intermittent preventive treatment of malaria in school-aged children (IPTsc) in moderate and high endemic areas in Tanzania: a policy brief
Implementation of the intermittent preventive treatment of malaria in school-aged children (IPTsc) in moderate and high endemic areas in Tanzania: a policy brief Open
The Global Fund, via the Ministry of Health, Tanzania (implementation research pilot of IPTsc), and Flemish Interuniversity Council (VLIR-UOS), Belgium, TEAM initiative, grant TZ2017TEA451A102 (clinical trial).
View article: Implementation and effectiveness of intermittent preventive treatment in school aged children using dihydroartemisinin-piperaquine to reduce malaria burden: an implementation research of a cluster randomised trial in Tanzania
Implementation and effectiveness of intermittent preventive treatment in school aged children using dihydroartemisinin-piperaquine to reduce malaria burden: an implementation research of a cluster randomised trial in Tanzania Open
The Global Fund, through the Ministry of Health, Tanzania, funded the study.
View article: Clinical Trials of Fetal Therapy With Continuing Neonatal Interventions: Legal Requirements and Customary Procedures Regarding Parental Consent. <i>The BOOSTB4 Trial as a Case Study</i>
Clinical Trials of Fetal Therapy With Continuing Neonatal Interventions: Legal Requirements and Customary Procedures Regarding Parental Consent. <i>The BOOSTB4 Trial as a Case Study</i> Open
Objective To analyze the legal consent requirements and customary procedures in clinical trials of fetal therapy with continuing neonatal interventions across four European countries using the BOOSTB4 trial as a case study. Methods The stu…
View article: Protocol for a systematic review of wearable devices for antenatal fetal monitoring
Protocol for a systematic review of wearable devices for antenatal fetal monitoring Open
Introduction Fetal monitoring is a crucial component of antenatal care, facilitating early detection of fetal compromise and improving pregnancy outcomes. Traditional monitoring methods such as cardiotocography (CTG) and ultrasound are eff…
View article: Scanner‐based real‐time automated volumetry reporting of the fetus, amniotic fluid, placenta, and umbilical cord for fetal MRI at 0.55T
Scanner‐based real‐time automated volumetry reporting of the fetus, amniotic fluid, placenta, and umbilical cord for fetal MRI at 0.55T Open
Purpose This work aims to enable real‐time automated intra‐uterine volumetric reporting and fetal weight estimation for fetal MRI, deployed directly on the scanner. Methods A multi‐region segmentation nnUNet was trained on 146 images of 73…
View article: Postnatal healing of cesarean scar: an ultrasound study
Postnatal healing of cesarean scar: an ultrasound study Open
Advanced cervical dilatation and low fetal station at emergency cesarean delivery in labor are independent predictors of cesarean scar location near or within the cervix, and these cervical scars heal less well than scars located higher in…
View article: ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth
ABO blood group antigens influence host–microbe interactions and risk of early spontaneous preterm birth Open
The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic ( n = 596) and immune profiling ( …
View article: Antioxidants: powering the fight against fetal hypoxia
Antioxidants: powering the fight against fetal hypoxia Open
Hypoxia is a common challenge in fetal development. Short-term acute episodes occur during labour owing to uterine contractions or umbilical cord compression. In response, the fetus prioritizes oxygen and nutrient delivery to the brain, he…
View article: Automated biometry for assessing cephalopelvic disproportion in 3D 0.55T fetal MRI at term
Automated biometry for assessing cephalopelvic disproportion in 3D 0.55T fetal MRI at term Open
Fetal MRI offers detailed three-dimensional visualisation of both fetal and maternal pelvic anatomy, allowing for assessment of the risk of cephalopelvic disproportion and obstructed labour. However, conventional measurements of fetal and …
View article: Predicting and preventing preterm birth in Europe: current challenges and gaps
Predicting and preventing preterm birth in Europe: current challenges and gaps Open
The PTB burden is a persistent concern across Europe. Constituent populations are diverse, comprising a mosaic of risk factors of varying significance that fail to predict the majority of PTBs. During this time of evolving demographics in …
View article: Optimization of continuous-wave NIRS devices for placental monitoring. A simulation study
Optimization of continuous-wave NIRS devices for placental monitoring. A simulation study Open
Near infrared spectroscopy (NIRS) is an optical technique that is widely used to monitor tissue oxygenation. These devices take advantage of the near infrared light to monitor deep tissues like brain, muscle or placenta. In this study, we …
View article: Protocol for a systematic review of wearable devices for antenatal fetal monitoring
Protocol for a systematic review of wearable devices for antenatal fetal monitoring Open
Introduction Fetal monitoring is a crucial component of antenatal care, facilitating early detection of fetal compromise and improving pregnancy outcomes. Traditional monitoring methods such as cardiotocography (CTG) and ultrasound are eff…
View article: Deep Learning-Based Fetal Lung Segmentation from Diffusion-weighted MRI Images and Lung Maturity Evaluation for Fetal Growth Restriction
Deep Learning-Based Fetal Lung Segmentation from Diffusion-weighted MRI Images and Lung Maturity Evaluation for Fetal Growth Restriction Open
Fetal lung maturity is a critical indicator for predicting neonatal outcomes and the need for post-natal intervention, especially for pregnancies affected by fetal growth restriction. Intra-voxel incoherent motion analysis has shown promis…
View article: Author Reply
Author Reply Open
ObjectiveTo assess foetal circulating free foetal haemoglobin (fHbF) levels and heme defences, correlated to foetal circulatory biometry and foetal sex in severe early-onset foetal growth restriction (FGR).Design, Setting and PopulationA p…
View article: Scanner-based real-time automated volumetry reporting of the fetus, amniotic fluid, placenta and umbilical cord for fetal MRI at 0.55T
Scanner-based real-time automated volumetry reporting of the fetus, amniotic fluid, placenta and umbilical cord for fetal MRI at 0.55T Open
Purpose: This work aims to enable real-time automated intra-uterine volumetric reporting and fetal weight estimation for fetal MRI, deployed directly on the scanner. Methods: A multi-region segmentation nnUNet was trained on 146 bSSFP imag…
View article: Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study
Economic Impact of Severe Early‐Onset Foetal Growth Restriction: A Multicentre Prospective Cohort Study Open
Objective Foetal growth restriction (FGR) affects 10% of pregnancies, contributing to 30% of stillbirths. Current management of early‐onset FGR (< 32 + 0 weeks' gestation) delivers the foetus before stillbirth or irreversible organ damage.…
View article: Care of Women With Preterm Prelabour Rupture of the Membranes Prior to 24<sup>+0</sup> Weeks of Gestation
Care of Women With Preterm Prelabour Rupture of the Membranes Prior to 24<sup>+0</sup> Weeks of Gestation Open
Plain Language Summary Rupture of the membranes is commonly referred to as ‘waters breaking’. This usually occurs just before or during labour. In around three in 100 pregnancies it occurs before 37 +0 weeks of pregnancy (preterm), but the…
View article: Focussing on the origins of preterm birth: Why understanding aetiology is critical to optimising outcomes
Focussing on the origins of preterm birth: Why understanding aetiology is critical to optimising outcomes Open
Preterm birth is a central determinant of infant morbidity and mortality. Efforts to reduce its incidence must address the disparate underlying causes.
View article: Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study
Interleukin-1 receptor antagonist polymorphisms in women receiving epidural analgesia who develop maternal intrapartum fever: a prospective, multicentre Mendelian randomised study Open
ISRCTN99641204.
View article: Quantifying prenatal and postnatal mortality in extreme early onset fetal growth restriction: A systematic review and incidence analysis
Quantifying prenatal and postnatal mortality in extreme early onset fetal growth restriction: A systematic review and incidence analysis Open
Background and Objective Extreme early‐onset fetal growth restriction (EE‐FGR) is associated with significant perinatal morbidity and mortality. As short‐ and long‐term prognoses are influenced by both gestational age and severity of FGR, …
View article: Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction
Placental Protein Citrullination Signatures Are Modified in Early- and Late-Onset Fetal Growth Restriction Open
Fetal growth restriction (FGR) is an obstetric condition most frequently caused by placental dysfunction. It is a major cause of perinatal morbidity with limited treatment options, so identifying the underpinning mechanisms is important. P…