Anna Doetsch
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View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug-resistan…
View article: Within-host evolution of drug tolerance in <i>Mycobacterium tuberculosis</i>
Within-host evolution of drug tolerance in <i>Mycobacterium tuberculosis</i> Open
Synopsis Background Mycobacterium tuberculosis (Mtb) causes tuberculosis (TB) in humans. Poor treatment responses are a threat to global TB control, as such, understanding contributing factors to poor responses is important. We hypothesize…
View article: Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage
Variability in intrinsic drug tolerance in <i>Mycobacterium tuberculosis</i> corresponds with phylogenetic lineage Open
Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug resistan…
View article: Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis
Drug-induced differential culturability in diverse strains of Mycobacterium tuberculosis Open
Under stress, bacteria display selective growth propensities on solid and liquid media. For Mycobacterium tuberculosis (Mtb), differentially culturable bacteria have been found in tuberculosis (TB) patient sputa. We hypothesized that antib…
View article: Drug-induced differential culturability in diverse strains of<i>Mycobacterium tuberculosis</i>
Drug-induced differential culturability in diverse strains of<i>Mycobacterium tuberculosis</i> Open
Differential culturable bacteria grow in liquid culture medium but are unable to form colonies on solid medium. Differentially culturable Mycobacterium tuberculosis (Mtb) bacteria, have been found in tuberculosis (TB) patient sputa. We hyp…
View article: Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study
Effect of compensatory evolution in the emergence and transmission of rifampicin-resistant Mycobacterium tuberculosis in Cape Town, South Africa: a genomic epidemiology study Open
Funding for this study was provided by a Swiss and South Africa joint research award (grant numbers 310030_188888, CRSII5_177163, and IZLSZ3_170834), the European Research Council (grant number 883582), and a Wellcome Trust fellowship (to …
View article: Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania
Genome-to-genome analysis reveals associations between human and mycobacterial genetic variation in tuberculosis patients from Tanzania Open
The risk and prognosis of tuberculosis (TB) are affected by both human and bacterial genetic factors. To identify interacting human and bacterial genetic loci, we leveraged paired human and Mycobacterium tuberculosis ( M . tb ) genomic dat…
View article: Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study
Whole-Genome Sequencing Has the Potential To Improve Treatment for Rifampicin-Resistant Tuberculosis in High-Burden Settings: a Retrospective Cohort Study Open
Treatment of multidrug-resistant or rifampicin-resistant tuberculosis (MDR/RR-TB), although improved in recent years with shorter, more tolerable regimens, remains largely standardized and based on limited drug susceptibility testing (DST)…
View article: Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South Africa
Rifampicin-Monoresistant Tuberculosis Is Not the Same as Multidrug-Resistant Tuberculosis: a Descriptive Study from Khayelitsha, South Africa Open
Rifampin monoresistance (RMR; rifampin resistance and isoniazid susceptibility) accounts for 38% of all rifampin-resistant tuberculosis (RR-TB) in South Africa and is increasing. We aimed to compare RMR-TB with multidrug-resistant TB (MDR-…
View article: Rifampicin mono-resistant tuberculosis is not the same as multidrug-resistant tuberculosis: a descriptive study from Khayelitsha, South Africa
Rifampicin mono-resistant tuberculosis is not the same as multidrug-resistant tuberculosis: a descriptive study from Khayelitsha, South Africa Open
Rifampicin mono-resistant TB (RMR-TB) constitutes 38% of all rifampicin-resistant TB (RR-TB) in South Africa and is increasing. We aimed to compare RMR-TB with multidrug-resistant TB (MDR-TB) within a high TB, RR-TB and HIV burden setting.…
View article: Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania
Insights into the genetic diversity of Mycobacterium tuberculosis in Tanzania Open
This study provides novel insights into the MTBC lineages and the possible influence of pathogen-related factors on the TB epidemic in Tanzania.
View article: Insights into the genetic diversity of<i>Mycobacterium tuberculosis</i>in Tanzania
Insights into the genetic diversity of<i>Mycobacterium tuberculosis</i>in Tanzania Open
Background Human tuberculosis (TB) is caused by seven phylogenetic lineages of the Mycobacterium tuberculosis complex (MTBC), Lineage 1–7. Recent advances in rapid genotyping of MTBC based on single nucleotide polymorphisms (SNP), allow fo…