Anna Evans Phillips
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View article: Individual Autonomic Profiles Influence Brain–Heart Connectivity in Tonic Pain
Individual Autonomic Profiles Influence Brain–Heart Connectivity in Tonic Pain Open
These findings highlight the stability of brain-heart coherence during resting and tonic pain in healthy individuals. However, individual autonomic profiles influenced coherence, with enhanced synchronization in the PRD-decreased group and…
View article: Non-invasive investigation of the cardiodynamic response to breathing exercises in healthy individuals using impedance cardiography: a feasibility study v1
Non-invasive investigation of the cardiodynamic response to breathing exercises in healthy individuals using impedance cardiography: a feasibility study v1 Open
Respiratory exercises are widely prescribed in physiotherapy to improve lung volumes, facilitate airway clearance, and enhance respiratory muscle performance. Techniques such as, diaphragmatic breathing, slow deep breathing, huffing and po…
View article: Prevalence and Patterns of Opioid Use in Chronic Pancreatitis
Prevalence and Patterns of Opioid Use in Chronic Pancreatitis Open
INTRODUCTION: Opioids are used to treat pain in chronic pancreatitis (CP), but little is known about current use patterns. The aim of this study was to characterize the utilization of opioids and associations with clinical characteristics …
View article: Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study
Geographic Differences in the Quality of Life Associated With Chronic Pancreatitis: An International, Multicenter Study Open
There appear to be demographic, etiological, and quality of life differences in the experience of CP across different populations. Reasons for these differences, including potential cultural and societal forces, need to be further explored.
View article: Symptom Burden After Acute Pancreatitis and Its Correlation With Exocrine Pancreatic Function: A Multicenter Prospective Study
Symptom Burden After Acute Pancreatitis and Its Correlation With Exocrine Pancreatic Function: A Multicenter Prospective Study Open
INTRODUCTION: Gastrointestinal (GI) symptoms and weight loss develop during and after acute pancreatitis (AP), but remain understudied. In this prospective, multicenter study, we aim to assess GI symptom burden and weight loss and their co…
View article: Proton-Pump Inhibitors and Fat Absorption in Cystic Fibrosis and Pancreatic Insufficiency: A Randomized Crossover Pilot Trial
Proton-Pump Inhibitors and Fat Absorption in Cystic Fibrosis and Pancreatic Insufficiency: A Randomized Crossover Pilot Trial Open
These limited descriptive pilot study results in participants with CF and EPI on PERT evaluated by stool, blood, and QOL tests did not suggest improvement in fat absorption attributable to PPI.
View article: Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature
Natural history of spontaneous pancreatic portal vein fistulae: A systematic review of the literature Open
PPVF is a rare and potentially fatal condition, though rates of bleeding complication and death were relatively low in this population. High-quality observational studies are needed to better understand the pathophysiology and natural hist…
View article: Prevalence of exocrine pancreatic insufficiency at 12 months after acute pancreatitis: a prospective, multicentre, longitudinal cohort study
Prevalence of exocrine pancreatic insufficiency at 12 months after acute pancreatitis: a prospective, multicentre, longitudinal cohort study Open
This study was supported by an Investigator Initiated Research Grant from AbbVie, Inc.
View article: Bidirectional relationship between acute pancreatitis and pancreatic cancer
Bidirectional relationship between acute pancreatitis and pancreatic cancer Open
Purpose of review The burdens of pancreatic ductal adenocarcinoma (PDAC) and acute pancreatitis are increasing globally. We reviewed current literature on whether acute pancreatitis is a causal factor for PDAC and examined clinical manifes…
View article: Analgesia for the treatment of acute pancreatitis: a protocol for a systematic review and network meta-analysis
Analgesia for the treatment of acute pancreatitis: a protocol for a systematic review and network meta-analysis Open
Introduction Gastrointestinal hospitalisations in the USA cause over US$130 billion in expenditures, and acute pancreatitis is a leading cause of these hospitalisations. Adequate pain control is one of the primary treatment goals for acute…
View article: Interventions for Pancreatitis—New Approaches, Knowledge Gaps, and Research Opportunities
Interventions for Pancreatitis—New Approaches, Knowledge Gaps, and Research Opportunities Open
There exists no cure for acute, recurrent acute or chronic pancreatitis and treatments to date have been focused on managing symptoms. A recent workshop held by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) f…
View article: Pancreatic quantitative sensory testing to predict treatment response of endoscopic therapy or surgery for painful chronic pancreatitis with pancreatic duct obstruction: study protocol for an observational clinical trial
Pancreatic quantitative sensory testing to predict treatment response of endoscopic therapy or surgery for painful chronic pancreatitis with pancreatic duct obstruction: study protocol for an observational clinical trial Open
Introduction Treatment for abdominal pain in patients with chronic pancreatitis (CP) remains challenging in the setting of central nervous system sensitisation, a phenomenon of remodelling and neuronal hyperexcitability resulting from pers…
View article: Clinical diagnosis of psychiatric comorbidities, performance of screening tests and pattern of psychotropic medication use in patients with chronic pancreatitis
Clinical diagnosis of psychiatric comorbidities, performance of screening tests and pattern of psychotropic medication use in patients with chronic pancreatitis Open
Psychiatric comorbidities are common among CP patients and many receive psychotropic medications. Further studies are needed to evaluate the impact of these medications on CP symptoms.
View article: Recent advances in the understanding and management of chronic pancreatitis pain
Recent advances in the understanding and management of chronic pancreatitis pain Open
Abdominal pain is the most common symptom of chronic pancreatitis (CP) and is often debilitating for patients and very difficult to treat. To date, there exists no cure for the disease. Treatment strategies focus on symptom management and …
View article: Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis Open
Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new cl…
View article: Outcomes of contemporary novel agent incorporation in relapsed/refractory PTCL
Outcomes of contemporary novel agent incorporation in relapsed/refractory PTCL Open
Background: Conventional salvage chemotherapy has limited efficacy in relapsed/refractory (R/R) peripheral T-cell lymphoma (PTCL). In the last decade, several novel agents have been approved; however, their impact on real world survival re…
View article: Pancreatic Malakoplakia: A Rare Pathology Associated With Acute Pancreatitis
Pancreatic Malakoplakia: A Rare Pathology Associated With Acute Pancreatitis Open
Malakoplakia is a rare granulomatous tumor-like inflammatory condition, most frequently involving the genitourinary system and occurring in immunosuppressed patients. The gastrointestinal tract is the second most common site, where it is u…
View article: Electrocardiography Assessment of Sympatico–Vagal Balance during Resting and Pain Using the Texas Instruments ADS1299
Electrocardiography Assessment of Sympatico–Vagal Balance during Resting and Pain Using the Texas Instruments ADS1299 Open
Sympatico–vagal balance is essential for regulating cardiac electrophysiology and plays an important role in arrhythmogenic conditions. Various noninvasive methods, including electrocardiography (ECG), have been used for clinical assessmen…
View article: Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study
Severe acute pancreatitis exhibits distinct cytokine signatures and trajectories in humans: a prospective observational study Open
In this study, we showed that the proinflammatory cytokine response in SAP is an early event, with subsequent downregulation of proinflammatory cytokines beginning at day 1 of symptom onset. Our findings underscore the importance of enroll…
View article: Clinical Trials in Pancreatitis: Opportunities and Challenges in the Design and Conduct of Patient-Focused Clinical Trials in Recurrent Acute and Chronic Pancreatitis
Clinical Trials in Pancreatitis: Opportunities and Challenges in the Design and Conduct of Patient-Focused Clinical Trials in Recurrent Acute and Chronic Pancreatitis Open
Recurrent acute pancreatitis and chronic pancreatitis represent high morbidity diseases, which are frequently associated with chronic abdominal pain, pancreatic insufficiencies, and reduced quality of life. Currently, there are no therapie…
View article: External nasal dilator decreases N95 respirator-related respiratory effort and symptoms in gastrointestinal endoscopy unit staff
External nasal dilator decreases N95 respirator-related respiratory effort and symptoms in gastrointestinal endoscopy unit staff Open
Background and study aims N95-filtering facepiece respirators (FFR) use is associated with physiological changes and symptoms due to impaired nasal airflow and increased breathing resistance. We prospectively studied the effect of using an…
View article: Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study
Rationale and Design for the Diabetes RElated to Acute Pancreatitis and Its Mechanisms Study Open
Acute pancreatitis (AP) is a disease characterized by an acute inflammatory phase followed by a convalescent phase. Diabetes mellitus (DM) was historically felt to be a transient phenomenon related to acute inflammation; however, it is inc…
View article: Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies
Characterizing mechanism-based pain phenotypes in patients with chronic pancreatitis: a cross-sectional analysis of the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translational StuDies Open
Pain is common in chronic pancreatitis (CP) and profoundly reduces quality of life (QoL). Multiple underlying mechanisms contribute to a heterogenous pain experience and reduce efficacy of pain management. This study was designed to charac…