Anna E. Schager
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View article: Wild-type and single-O-antigen repeat outer-membrane vesicles induce equivalent protection against homologous and heterologous<i>Salmonella</i>challenge
Wild-type and single-O-antigen repeat outer-membrane vesicles induce equivalent protection against homologous and heterologous<i>Salmonella</i>challenge Open
Lipopolysaccharide O-antigen is an immunodominant target of protective antibodies. Variation in O-antigen structures limits antibody-mediated cross-protection between closely-related pathogens including Salmonella Typhimurium (STm) and S .…
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Introduction Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better …
View article: Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses
Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses Open
Vaccination with Vi capsular polysaccharide (Vi-PS) or protein-Vi typhoid conjugate vaccine (TCV) can protect adults against Salmonella Typhi infections. TCVs offer better protection than Vi-PS in infants and may offer better protection in…
View article: YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium
YraP Contributes to Cell Envelope Integrity and Virulence of Salmonella enterica Serovar Typhimurium Open
Mutations in σ E -regulated lipoproteins have previously been shown to impact bacterial viability under conditions of stress and during in vivo infection. YraP is conserved across a number of Gram-negative pathogens, including Neisseria me…
View article: IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal<i>Salmonella</i>Develop at Discordant Rates
IgG Responses to Porins and Lipopolysaccharide within an Outer Membrane-Based Vaccine against Nontyphoidal<i>Salmonella</i>Develop at Discordant Rates Open
Antibodies acquired after vaccination or natural infection with Gram-negative bacteria, such as invasive Salmonella enterica serovar Typhimurium, can protect against disease. Immunization with naturally shed outer membrane vesicles from Gr…
View article: Role of a single noncoding nucleotide in the evolution of an epidemic African clade of <i>Salmonella</i>
Role of a single noncoding nucleotide in the evolution of an epidemic African clade of <i>Salmonella</i> Open
Significance Invasive nontyphoidal Salmonella disease is a major and previously neglected tropical disease responsible for an estimated ∼390,000 deaths per year in Africa, largely caused by a variant of Salmonella Typhimurium called ST313.…
View article: IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from <i>Salmonella</i> Typhimurium
IgG1 Is Required for Optimal Protection after Immunization with the Purified Porin OmpD from <i>Salmonella</i> Typhimurium Open
In mice, the IgG subclass induced after Ag encounter can reflect the nature of the Ag. Th2 Ags such as alum-precipitated proteins and helminths induce IgG1, whereas Th1 Ags, such as Salmonella Typhimurium, predominantly induce IgG2a. The c…