Anna Waller
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View article: TIN-X version 3: update with expanded dataset and modernized architecture for enhanced illumination of understudied targets
TIN-X version 3: update with expanded dataset and modernized architecture for enhanced illumination of understudied targets Open
TIN-X (Target Importance and Novelty eXplorer) is an interactive visualization tool for illuminating associations between diseases and potential drug targets and is publicly available at newdrugtargets.org . TIN-X uses natural language pro…
View article: EMS injury cause codes more accurate than emergency department visit ICD-10-CM codes for firearm injury intent in North Carolina
EMS injury cause codes more accurate than emergency department visit ICD-10-CM codes for firearm injury intent in North Carolina Open
Background The timeliness, accuracy, and completeness of data for firearm injury surveillance is crucial for public health surveillance efforts and informing injury prevention measures. While emergency department (ED) visit data can provid…
View article: The impact of the COVID-19 pandemic on the utilization of emergency department services for the treatment of injuries
The impact of the COVID-19 pandemic on the utilization of emergency department services for the treatment of injuries Open
Context: The global COVID-19 pandemic has had a major impact on the utilization of healthcare services; however, the impact on population-level emergency department (ED) utilization patterns for the treatment of acute injuries has not been…
View article: Overview of the Knowledge Management Center for Illuminating the Druggable Genome
Overview of the Knowledge Management Center for Illuminating the Druggable Genome Open
The Knowledge Management Center (KMC) for the Illuminating the Druggable Genome (IDG) project aims to aggregate, update, and articulate protein-centric data knowledge for the entire human proteome, with emphasis on the understudied protein…
View article: Racial and ethnic disparities in motor vehicle crash-related outcomes in North Carolina surrounding the COVID-19 pandemic
Racial and ethnic disparities in motor vehicle crash-related outcomes in North Carolina surrounding the COVID-19 pandemic Open
Long-term impacts of the COVID-19 pandemic on racial and ethnic disparities in motor vehicle crash (MVC) injuries and death are poorly understood. This study aimed to characterize trends and investigate the heterogeneity of MVC-related dis…
View article: Linking Emergency Medical Services and Emergency Department Data to Improve Overdose Surveillance in North Carolina
Linking Emergency Medical Services and Emergency Department Data to Improve Overdose Surveillance in North Carolina Open
Introduction Linking emergency medical services (EMS) data to emergency department (ED) data enables assessing the continuum of care and evaluating patient outcomes. We developed novel methods to enhance linkage performance and analysis of…
View article: A Mixed-Methods Comparison of a National and State Opioid Overdose Surveillance Definition
A Mixed-Methods Comparison of a National and State Opioid Overdose Surveillance Definition Open
Objectives We assessed the differences between the first version of the Centers for Disease Control and Prevention (CDC) opioid surveillance definition for suspected nonfatal opioid overdoses (hereinafter, CDC definition) and the North Car…
View article: Why Do Patients With Cancer Visit Emergency Departments? Results of a 2008 Population Study in North Carolina
Why Do Patients With Cancer Visit Emergency Departments? Results of a 2008 Population Study in North Carolina Open
Purpose Emergency departments (EDs) in the United States are used by patients with cancer for disease or treatment-related problems and unrelated issues. The North Carolina Disease Event Tracking and Epidemiologic Collection Tool (NC DETEC…
View article: TIGA: target illumination GWAS analytics
TIGA: target illumination GWAS analytics Open
Motivation Genome-wide association studies can reveal important genotype–phenotype associations; however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the …
View article: TIGA: Target illumination GWAS analytics
TIGA: Target illumination GWAS analytics Open
Genome wide association studies (GWAS) can reveal important genotype–phenotype associations, however, data quality and interpretability issues must be addressed. For drug discovery scientists seeking to prioritize targets based on the avai…
View article: Improvements in Timeliness Resulting from Implementation of Electronic Laboratory Reporting and an Electronic Disease Surveillance System
Improvements in Timeliness Resulting from Implementation of Electronic Laboratory Reporting and an Electronic Disease Surveillance System Open
Electronic laboratory reporting (ELR) reduces the time between communicable disease diagnosis and case reporting to local health departments (LHDs). However, it also imposes burdens on public health agencies, such as increases in the numbe…
View article: Integration of Syndromic Surveillance Data into Public Health Practice at State and Local Levels in North Carolina
Integration of Syndromic Surveillance Data into Public Health Practice at State and Local Levels in North Carolina Open
We sought to describe the integration of syndromic surveillance data into daily surveillance practice at local health departments (LHDs) and make recommendations for the effective integration of syndromic and reportable disease data for pu…
View article: Risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households
Risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households Open
More needs to be known about the prevalence of risk and protective factors for fires, burns, and carbon monoxide poisoning in U.S. households.
View article: Why Do Cancer Patients Die in the Emergency Department?: An Analysis of 283 Deaths in NC EDs
Why Do Cancer Patients Die in the Emergency Department?: An Analysis of 283 Deaths in NC EDs Open
Emergency department (ED) visits are made by cancer patients for symptom management, treatment effects, oncologic emergencies, or end of life care. While most patients prefer to die at home, many die in health care institutions. The purpos…
View article: TCRD and Pharos 2021: mining the human proteome for disease biology
TCRD and Pharos 2021: mining the human proteome for disease biology Open
In 2014, the National Institutes of Health (NIH) initiated the Illuminating the Druggable Genome (IDG) program to identify and improve our understanding of poorly characterized proteins that can potentially be modulated using small molecul…
View article: How to Illuminate the Druggable Genome Using Pharos
How to Illuminate the Druggable Genome Using Pharos Open
Pharos is an integrated web‐based informatics platform for the analysis of data aggregated by the Illuminating the Druggable Genome (IDG) Knowledge Management Center, an NIH Common Fund initiative. The current version of Pharos (as of Octo…
View article: Follow Me: The Use of Social Media in Recruitment
Follow Me: The Use of Social Media in Recruitment Open
The use of social media in the human resource arena continues to increase including a growing use of the internet for prescreening applicants during the recruitment process. With so many diverse social networking websites applicants use to…
View article: Variability in Hospital Admission Rates for Neonates With Fever in North Carolina
Variability in Hospital Admission Rates for Neonates With Fever in North Carolina Open
Background. Despite multiple guidelines recommending admission, there is significant variation among emergency departments (EDs) regarding disposition of neonates presenting with fever. We performed a statewide epidemiologic analysis to id…
View article: Informing Public Health Prevention in NC Using Falls Surveillance Data
Informing Public Health Prevention in NC Using Falls Surveillance Data Open
ObjectiveTo describe how a successful partnership between state public health and a university organization has used epidemiologic data, such as mortality, hospital discharge, and emergency department (ED) visit data, to inform falls preve…
View article: Activation of Rho Family GTPases by Small Molecules
Activation of Rho Family GTPases by Small Molecules Open
Ras and Ras-related small GTPases are key regulators of diverse cellular functions that impact cell growth, survival, motility, morphogenesis, and differentiation. They are important targets for studies of disease mechanisms as well as dru…
View article: High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL
High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL Open
Kinase inhibitors have dramatically increased patient survival in a multitude of cancers, including hematological malignancies. However, kinase inhibitors have not yet been integrated into current clinical trials for patients with T-cell-l…
View article: Characteristics of sports and recreation-related emergency department visits among school-age children and youth in North Carolina, 2010–2014
Characteristics of sports and recreation-related emergency department visits among school-age children and youth in North Carolina, 2010–2014 Open
Sports and recreational activities are an important component of a healthy lifestyle, but they are also a major source of injury morbidity among school-age youth. Physical activity interventions should take into account sex and age differe…
View article: High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining
High-Throughput Screening Approach for Identifying Compounds That Inhibit Nonhomologous End Joining Open
DNA double-strand breaks (DSBs) are repaired primarily by homologous recombination (HR) or nonhomologous end joining (NHEJ). Compounds that modulate HR have shown promise as cancer therapeutics. The V(D)J recombination reaction, which asse…
View article: TIN-X: target importance and novelty explorer
TIN-X: target importance and novelty explorer Open
Motivation The increasing amount of peer-reviewed manuscripts requires the development of specific mining tools to facilitate the visual exploration of evidence linking diseases and proteins. Results We developed TIN-X, the Target Importan…