Anna Ebbesson
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View article: Copy number signatures in cervical samples enable early detection of high-grade serous ovarian carcinoma
Copy number signatures in cervical samples enable early detection of high-grade serous ovarian carcinoma Open
Background Ovarian cancer is often diagnosed in advanced stages, resulting in poor outcomes. There is an unmet need for a sensitive and specific screening tool for early-stage detection of ovarian cancer. Methods Recognizing that high-grad…
View article: Molecular patterns of resistance to immune checkpoint blockade in melanoma
Molecular patterns of resistance to immune checkpoint blockade in melanoma Open
Immune checkpoint blockade (ICB) has improved outcome for patients with metastatic melanoma but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we nee…
View article: Molecular patterns of resistance to immune checkpoint blockade in melanoma
Molecular patterns of resistance to immune checkpoint blockade in melanoma Open
Immune checkpoint blockade (ICB) has improved outcome for metastatic melanoma patients but not all benefit from treatment. Several immune- and tumor intrinsic features are associated with clinical response at baseline. However, we need to …
View article: Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer
Oncogenic translation directs spliceosome dynamics revealing an integral role for SF3A3 in breast cancer Open
Splicing is a central RNA-based process commonly altered in human cancers; however, how spliceosomal components are co-opted during tumorigenesis remains poorly defined. Here we unravel the core splice factor SF3A3 at the nexus of a transl…
View article: Additional file 1 of Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer
Additional file 1 of Distinct mechanisms of resistance to fulvestrant treatment dictate level of ER independence and selective response to CDK inhibitors in metastatic breast cancer Open
Additional file 1. Table showing normalized gene expression data from parental and fulvestrant-resistant CAMA-1, MCF7, T47D and HCC1428 cell lines.
View article: SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery
SOX2 is a promising predictor of relapse and death in advanced stage high-grade serous ovarian cancer patients with residual disease after debulking surgery Open
The transcription factor SOX2 is a well-established and important stem cell marker. Its role in cancer biology remains unclear, but it has been proposed to also be a marker of cancer stem cells. We investigated the role of SOX2 protein exp…
View article: Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma
Involvement of Chromatin Remodeling Genes and the Rho GTPases RhoB and CDC42 in Ovarian Clear Cell Carcinoma Open
OCCCs appear genetically heterogeneous, but harbor frequent alterations in chromatin remodeling genes. Overexpression of TFAP2A and ERBB2 was observed on the mRNA level in relation to other ovarian cancer subtypes. However, overexpression …
View article: Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response
Claudin-4 Expression is Associated With Survival in Ovarian Cancer But Not With Chemotherapy Response Open
The tight junction protein claudin-4 has been reported to be overexpressed in advanced ovarian cancer. We investigated the prognostic significance of claudin-4 overexpression and whether claudin-4 expression could predict platinum response…