Anna Ellsworth
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View article: The association between preconception polycystic ovary syndrome and gestational diabetes mellitus among women with and without pre-pregnancy hypertension: a cross-sectional study from Utah’s Pregnancy Risk Assessment Monitoring System Survey (2016-2021)
The association between preconception polycystic ovary syndrome and gestational diabetes mellitus among women with and without pre-pregnancy hypertension: a cross-sectional study from Utah’s Pregnancy Risk Assessment Monitoring System Survey (2016-2021) Open
These findings show that women with PCOS are at high risk for GDM, among a population-based sample of mothers. Interventions to reduce the risk of GDM among women with PCOS need to be developed and evaluated.
View article: Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes
Tau Modulates mRNA Transcription, Alternative Polyadenylation Profiles of hnRNPs, Chromatin Remodeling and Spliceosome Complexes Open
Tau protein is a known contributor in several neurodegenerative diseases, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD). It is well-established that tau forms pathological aggregates and fibrils in these diseases. Ta…
View article: Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes
Tau modulates mRNA transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes Open
Tau protein is a known contributor in several neurodegenerative diseases, including Alzheimer ‘s disease (AD) and frontotemporal dementia (FTD). It is well-established that tau forms pathological aggregates and fibrils in these diseases. T…
View article: TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia Open
Proteinaceous aggregates are major hallmarks of several neurodegenerative diseases. Aggregates of post-translationally modified transactive response (TAR)-DNA binding protein 43 (TDP-43) in cytoplasmic inclusion bodies are characteristic f…
View article: Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies
Internalization mechanisms of brain-derived tau oligomers from patients with Alzheimer’s disease, progressive supranuclear palsy and dementia with Lewy bodies Open
Tau aggregates propagate in brain cells and transmit to neighboring cells as well as anatomically connected brain regions by prion-like mechanisms. Soluble tau aggregates (tau oligomers) are the most toxic species that initiate neurodegene…
View article: Tau oligomers mediate aggregation of RNA‐binding proteins Musashi1 and Musashi2 inducing Lamin alteration
Tau oligomers mediate aggregation of RNA‐binding proteins Musashi1 and Musashi2 inducing Lamin alteration Open
The exact mechanisms leading to neurodegeneration in Alzheimer's disease (AD) and other tauopathies are not yet entirely understood. However, it is known that several RNA‐binding proteins (RBPs) form toxic aggregates and also interact with…
View article: P4‐520: TAU OLIGOMERS MEDIATE AGGREGATION OF RNA‐BINDING PROTEINS MUSASHI1‐ AND MUSASHI2‐INDUCING NUCLEAR MEMBRANE ALTERATION IN ALZHEIMER'S DISEASE
P4‐520: TAU OLIGOMERS MEDIATE AGGREGATION OF RNA‐BINDING PROTEINS MUSASHI1‐ AND MUSASHI2‐INDUCING NUCLEAR MEMBRANE ALTERATION IN ALZHEIMER'S DISEASE Open
RNA-Binding Proteins (RBPs) accumulate and aggregate in different neurodegenerative diseases, including Alzheimer's disease (AD). The Musashi (MSI) family is a group of RBPs which includes two homologous proteins, Musashi1 and Musashi2 (MS…
View article: Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury
Neurotoxic tau oligomers after single versus repetitive mild traumatic brain injury Open
Mild traumatic brain injury accounts for the majority of head injuries and has been correlated with neurodegeneration and dementia. While repetitive mild traumatic brain injury is highly correlated to neurodegeneration, the correlation of …
View article: Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior
Soluble tau aggregates, not large fibrils, are the toxic species that display seeding and cross‐seeding behavior Open
Several studies have proposed that fibrillary aggregates of tau and other amyloidogenic proteins are neurotoxic and result in numerous neurodegenerative diseases. However, these studies usually involve sonication or extrusion through needl…
View article: O2‐02‐06: PROPAGATION AND DIVERSE EFFECTS OF DISEASE‐SPECIFIC PRION‐LIKE TAU OLIGOMERIC STRAINS
O2‐02‐06: PROPAGATION AND DIVERSE EFFECTS OF DISEASE‐SPECIFIC PRION‐LIKE TAU OLIGOMERIC STRAINS Open
Tau aggregation is a common factor in many different neurodegenerative diseases, known as tauopathies. However, each tauopathy is characterized by a unique combination of symptoms and pathological hallmarks. A large body of research has sh…