Anna Fuller
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View article: 31 SLC45A2 is associated with diluted coat color in Dexter cattle.
31 SLC45A2 is associated with diluted coat color in Dexter cattle. Open
Dexter cattle are genotyped for variants in the melanocortin 1 receptor (MC1R) gene, which determines black (ED) or red (E+ or e) coat color, as well as for a previously identified Dexter-specific variant of tyrosinase related protein 1 (T…
View article: 30 Investigation into the relationship of mitochondrial haplotype on respiratory complex I activity in beef cattle skeletal muscle.
30 Investigation into the relationship of mitochondrial haplotype on respiratory complex I activity in beef cattle skeletal muscle. Open
Mitochondria regulate energy metabolism by converting nutrients into ATP through the process of oxidative phosphorylation. A series of protein complexes in the inner mitochondrial membrane facilitate ATP production via electron transfer, w…
View article: 29 Mitochondrial haplotype variation and its association with feed efficiency in beef cattle.
29 Mitochondrial haplotype variation and its association with feed efficiency in beef cattle. Open
The mitochondrion, an organelle inherited exclusively from the mother, is responsible for generating approximately 90% of total cellular energy and harbors a unique genome (mtDNA). This genome is composed of 13 essential protein-coding gen…
View article: Mitochondrial Introgression With Potential Functional Effects in North American Yak
Mitochondrial Introgression With Potential Functional Effects in North American Yak Open
The domestic yak ( Bos grunniens ) has experienced introgression with domestic cattle in its native Qinghai‐Tibetan Plateau and after introduction to North America (NA), although the extent to which the latter has occurred is not well docu…
View article: Changes in the skeletal muscle transcriptome due to the intramuscular administration of lidocaine in wether lambs
Changes in the skeletal muscle transcriptome due to the intramuscular administration of lidocaine in wether lambs Open
Lidocaine is a commonly used local anesthetic that blocks sodium channels in nociceptor neurons, preventing the transmission of pain signals to the brain. Lidocaine can be administered to reduce discomfort during tissue biopsies. Biopsy ti…
View article: MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain
MHC-related protein 1–restricted recognition of cancer via a semi-invariant TCR-α chain Open
The T cell antigen presentation platform MR1 consists of 6 allomorphs in humans that differ by no more than 5 amino acids. The principal function of this highly conserved molecule involves presenting microbial metabolites to the abundant m…
View article: HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes
HLA A*24:02–restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes Open
CD8+ T cells destroy insulin-producing pancreatic β cells in type 1 diabetes through HLA class I-restricted presentation of self-antigens. Combinatorial peptide library screening was used to produce a preferred peptide recognition landscap…
View article: 204 Changes in DNA methylation 5 days after exposure to acute heat stress in beef cattle skeletal muscle
204 Changes in DNA methylation 5 days after exposure to acute heat stress in beef cattle skeletal muscle Open
The objective of this study was to investigate the effects of acute heat stress on the skeletal muscle epigenome using reduced representation bisulfite sequencing (RRBS). March-born crossbred (5/8 Red Angus, 3/8 Simmental) steers (n = 14; …
View article: PSIII-21 Variation in mitochondrial genes involved in oxidative phosphorylation in cattle
PSIII-21 Variation in mitochondrial genes involved in oxidative phosphorylation in cattle Open
The mitochondrion is a maternally inherited organelle that produces approximately 90% of cellular energy. The mitochondrial genome (mtDNA) consists of 13 genes that are critical components of oxidative phosphorylation. Identifying and unde…
View article: 205 An autosomal recessive mutation in PYGM causes myophosphorylase deficiency in composite cattle
205 An autosomal recessive mutation in PYGM causes myophosphorylase deficiency in composite cattle Open
Between 2020 and 2022, eight calves (6 heifers, 2 bulls) in a Nebraska herd (composite Simmental, Red Angus, Gelbvieh) experienced exercise intolerance during extended physical activity. These calves exhibited an inability to keep pace wit…
View article: Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty
Puberty classifications in beef heifers are moderately to highly heritable and associated with candidate genes related to cyclicity and timing of puberty Open
Introduction: Pubertal attainment is critical to reproductive longevity in heifers. Previously, four heifer pubertal classifications were identified according to attainment of blood plasma progesterone concentrations > 1 ng/ml: 1) Early…
View article: A recessive <i>CLN3</i> variant is responsible for delayed-onset retinal degeneration in Hereford cattle
A recessive <i>CLN3</i> variant is responsible for delayed-onset retinal degeneration in Hereford cattle Open
Thirteen American Hereford cattle were reported blind with presumed onset when ~12-mo-old. All blind cattle shared a common ancestor through both the maternal and paternal pedigrees, suggesting a recessive genetic origin. Given the pedigre…
View article: Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy
Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy Open
The T cells of the immune system can target tumors and clear solid cancers following tumor-infiltrating lymphocyte (TIL) therapy. We used combinatorial peptide libraries and a proteomic database to reveal the antigen specificities of persi…
View article: Short Communication: Beta-adrenergic agonists alter oxidative phosphorylation in primary myoblasts
Short Communication: Beta-adrenergic agonists alter oxidative phosphorylation in primary myoblasts Open
Beta-adrenergic agonists (β-AAs) are widely used supplements in beef and pork production to improve feed efficiency and increase lean muscle mass, yet little is known about the molecular mechanism by which β-AAs achieve this outcome. Our o…
View article: Transcriptome analyses indicate that heat stress-induced inflammation in white adipose tissue and oxidative stress in skeletal muscle is partially moderated by zilpaterol supplementation in beef cattle
Transcriptome analyses indicate that heat stress-induced inflammation in white adipose tissue and oxidative stress in skeletal muscle is partially moderated by zilpaterol supplementation in beef cattle Open
Heat stress (HS) triggers oxidative stress, systemic inflammation, and disrupts growth efficiency of livestock. β-adrenergic agonists supplemented to ruminant livestock improve growth performance, increase skeletal muscle mass, and decreas…
View article: Beta-adrenergic agonists and heat stress impact skeletal muscle gene expression and mitochondrial function in beef cattle
Beta-adrenergic agonists and heat stress impact skeletal muscle gene expression and mitochondrial function in beef cattle Open
Open access journal
View article: Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope
Emergence of immune escape at dominant SARS-CoV-2 killer T-cell epitope Open
The adaptive immune system protects against infection via selection of specific antigen receptors on B-cells and T-cells. We studied the prevalent CD8 ‘killer’ T-cell response mounted against SARS-CoV-2 Spike 269-277 epitope YLQPRTFLL via …
View article: 17 A De novo Recessive Mutation Causative of Mandibulofacial Dysostosis in Hereford Cattle
17 A De novo Recessive Mutation Causative of Mandibulofacial Dysostosis in Hereford Cattle Open
In spring 2020, six Hereford calves presented with congenital craniofacial abnormalities attributed to a condition we termed mandibulofacial dysostosis (MD). Pedigree analysis revealed a single common ancestor shared by the sire and dam of…
View article: Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative
Generation of a Biobank From Two Adult Thoroughbred Stallions for the Functional Annotation of Animal Genomes Initiative Open
Following the successful creation of a biobank from two adult Thoroughbred mares, this study aimed to recapitulate sample collection in two adult Thoroughbred stallions as part of the Functional Annotation of the Animal Genome (FAANG) init…
View article: Magnitude and Kinetics of T Cell and Antibody Responses During H1N1pdm09 Infection in Inbred Babraham Pigs and Outbred Pigs
Magnitude and Kinetics of T Cell and Antibody Responses During H1N1pdm09 Infection in Inbred Babraham Pigs and Outbred Pigs Open
We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to the 2009 pandemic H1N1 virus infection. We evaluated the ki…
View article: PSI-40 Two mitochondrial lineages revealed in North American yak
PSI-40 Two mitochondrial lineages revealed in North American yak Open
Domestic yak (Bos grunniens) are bovids native to the Asian Qinghai-Tibetan Plateau. Studies of Asian yak have revealed that introgression with domestic cattle has contributed to the evolution of the species. When imported to North America…
View article: 256 Heat stress and β-adrenergic agonists alter the adipose transcriptome and fatty acid mobilization in ruminant livestock
256 Heat stress and β-adrenergic agonists alter the adipose transcriptome and fatty acid mobilization in ruminant livestock Open
Heat stress (HS) negatively impacts livestock performance and carcass traits while beta-adrenergic agonist (βAA) supplementation improves animal production and efficiency; both can stimulate lipolysis in adipose. The objective of this stud…
View article: Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs
Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs Open
We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, to characterize αβ, γδ T cell and antibody (Ab) immune responses to the 2009 pandemic H1N1 virus infection. We evaluated the ki…
View article: Mandibulofacial Dysostosis Attributed to a Recessive Mutation of CYP26C1 in Hereford Cattle
Mandibulofacial Dysostosis Attributed to a Recessive Mutation of CYP26C1 in Hereford Cattle Open
In spring 2020, six Hereford calves presented with congenital facial deformities attributed to a condition we termed mandibulofacial dysostosis (MD). Affected calves shared hallmark features of a variably shortened and/or asymmetric lower …
View article: GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope
GPU-Accelerated Discovery of Pathogen-Derived Molecular Mimics of a T-Cell Insulin Epitope Open
The strong links between (Human Leukocyte Antigen) HLA, infection and autoimmunity combine to implicate T-cells as primary triggers of autoimmune disease (AD). T-cell crossreactivity between microbially-derived peptides and self-peptides h…
View article: TCR‐induced alteration of primary MHC peptide anchor residue
TCR‐induced alteration of primary MHC peptide anchor residue Open
The HLA‐A*02:01‐restricted decapeptide EAAGIGILTV, derived from melanoma antigen recognized by T‐cells‐1 (MART‐1) protein, represents one of the best‐studied tumor associated T‐cell epitopes, but clinical results targeting this peptide hav…