Anna Graser
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View article: IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer
IL-9 Producing Tumor-Infiltrating Lymphocytes and Treg Subsets Drive Immune Escape of Tumor Cells in Non-Small Cell Lung Cancer Open
Although lung cancer is the leading cause of cancer deaths worldwide, the mechanisms how lung cancer cells evade the immune system remain incompletely understood. Here, we discovered IL-9-dependent signaling mechanisms that drive immune ev…
View article: Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers
Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers Open
Background The impact of physical activity on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. Our aims were to examine whether there were any differences in the level of physical …
View article: Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers
Physical activity in asthma control and its immune modulatory effect in asthmatic preschoolers Open
Background: The impact of physical activity (PA) on immune response is a hot topic in exercise immunology, but studies involving asthmatic children are scarce. We examine the level of PA and TV attendance (TVA) in asthmatic children to ass…
View article: IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma
IL-33/ST2 immune responses to respiratory bacteria in pediatric asthma Open
Here we investigated the relationship between local bacterial colonization and anti-bacterial immune responses in pre-school asthmatic and control children within the EU-wide study PreDicta. In this cohort of pre-school asthmatic children,…
View article: Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms – missing pieces of the puzzle of childhood asthma?
Rhinovirus species/genotypes and interferon-λ: subtypes, receptor and polymorphisms – missing pieces of the puzzle of childhood asthma? Open
The correspondence from C. Scagnolari and co-workers raises some interesting points that we could not address in a single manuscript, but were otherwise addressed in our Predicta study and will therefore be reported on in future. Analysis …
View article: IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma
IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma Open
The letter by S. Baraldo and co-workers raises some interesting points. It is correct that we cannot exclude the possibility that interferon upregulation during the acute phase in asthmatics, though existent, is suboptimal if compared to h…
View article: Role of TGF-β in anti-rhinovirus immune responses in asthmatic patients
Role of TGF-β in anti-rhinovirus immune responses in asthmatic patients Open
The majority of viral infections of the airways are associated with asthma exacerbations in children. Two thirds of these viral infections are caused by rhinovirus, and hospital admissions for asthma correlate with the seasonal peak of rhi…
View article: IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma
IFN-α/IFN-λ responses to respiratory viruses in paediatric asthma Open
We analysed the influence of rhinovirus (RV) in nasopharyngeal fluid (NPF) on type I and III interferon (IFN) responses ( e.g. IFN-α and IFN - λ) and their signal transduction, at baseline and during disease exacerbation, in cohorts of pre…