Anna Grebinyk
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View article: First high peak and average power single-pass THz free-electron laser in operation
First high peak and average power single-pass THz free-electron laser in operation Open
We report on the operation of the first high peak and average power single-pass terahertz free-electron laser (THz FEL) based on a high-brightness photoinjector for developing a THz source for pump-probe experiments at advanced x-ray FELs …
View article: Demonstration of ultra-high dose rate electron irradiation at FLASHlab@PITZ
Demonstration of ultra-high dose rate electron irradiation at FLASHlab@PITZ Open
Objective. The photo injector test facility at DESY in Zeuthen (PITZ) is building up an R&D platform, known as FLASH lab @PITZ, for systematically studying the FLASH effect in cancer treatment with its high-brightness electron beams, which…
View article: Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation
Polymeric nanoparticles with a thermoresponsive shell loaded with fluorescent molecules allow for thermally enhanced fluorescence imaging and singlet oxygen generation Open
Heating of core-thermoresponsive shell nanoparticles loaded with fluorescent molecules resulted in an increased fluorescence and singlet oxygen generation, which holds promise for thermally enhanced fluorescence bioimaging and photodynamic…
View article: From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells
From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells Open
Objectives: The primary objective of this research targeted the biochemical effects of SDT on human cervix carcinoma (HeLa) and mouse Lewis lung carcinoma (LLC) cells grown in 2D monolayer and 3D spheroid cell culture. Methods: HeLa and LL…
View article: First high peak and average power single-pass THz FEL based on high brightness photoinjector
First high peak and average power single-pass THz FEL based on high brightness photoinjector Open
Advanced experiments using THz pump and X-ray probe pulses at modern free-electron lasers (FELs) like the European X-ray FEL require a frequency-tunable, high-power, narrow-band THz source maintaining the repetition rate and pulse structur…
View article: Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro
Toxicity of Water-Soluble D-g-PNIPAM Polymers in a Complex with Chemotherapy Drugs and Mechanism of Their Action In Vitro Open
The application of a biocompatible polymer nanocarrier can provide target delivery to tumor tissues, improved pharmacokinetics, controlled drug release, etc. Therefore, the proposed strategy was to use the water-soluble star-like copolymer…
View article: THz SASE FEL at PITZ: lasing at a wavelength of 100 μm
THz SASE FEL at PITZ: lasing at a wavelength of 100 μm Open
Development of an accelerator-based tunable THz source prototype for pump-probe experiments at the European XFEL is ongoing at the Photo Injector Test facility at DESY in Zeuthen (PITZ). The proof-of-principle experiments on the THz SASE F…
View article: Comparison of measurements and simulation results of dose for the flash radiation therapy beamline at PITZ
Comparison of measurements and simulation results of dose for the flash radiation therapy beamline at PITZ Open
The high-brightness electron beam at the Photo Injector Test facility at DESY in Zeuthen (PITZ) is now also used for FLASHlab@PITZ: an R.&D platform for studying radiation biology and the FLASH effect in radiation therapy. The available pa…
View article: Overview of FLASHlab@PITZ: the new R&D platform for FLASH radiation therapy and radiation biology
Overview of FLASHlab@PITZ: the new R&D platform for FLASH radiation therapy and radiation biology Open
An R&D platform for electron FLASH radiation therapy and radiation biology is being prepared at the Photo Injector Test facility at DESY in Zeuthen (FLASH lab @PITZ). This platform is based on the unique beam parameters available at PITZ: …
View article: A beam line setup for flash radiation therapy with focused electron beams at the PITZ facility at desy in zeuthen: Basic concept and dosimetry simulations
A beam line setup for flash radiation therapy with focused electron beams at the PITZ facility at desy in zeuthen: Basic concept and dosimetry simulations Open
The objective of this study is demonstration of the principal possibility to increase the electron beam dose deposition at the certain depth of the sample for radiation therapy purposes. Electron bunches of 22 MeV within train generated at…
View article: Comparison of Sonodynamic Treatment Set-Ups for Cancer Cells with Organic Sonosensitizers and Nanosonosensitizers
Comparison of Sonodynamic Treatment Set-Ups for Cancer Cells with Organic Sonosensitizers and Nanosonosensitizers Open
Cancer sonodynamic therapy (SDT) is the therapeutic strategy of a high-frequency ultrasound (US) combined with a special sonosensitizer that becomes cytotoxic upon US exposure. The growing number of newly discovered sonosensitizers and cus…
View article: First high peak and average power THz SASE FEL in operation
First high peak and average power THz SASE FEL in operation Open
Advanced experiments using THz pump and X-ray probe pulses at modern free-electron lasers (FELs) like the European X-ray FEL require a frequency-tunable (from 0.1 THz to 30 THz), high-power (> 10 microjoule), narrow-band (~ 1–2%) THz sourc…
View article: Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells
Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells Open
The acoustic pressure waves of ultrasound (US) not only penetrate biological tissues deeper than light, but they also generate light emission, termed sonoluminescence. This promoted the idea of its use as an alternative energy source for p…
View article: Sensor Systems with Optical Reponse
Sensor Systems with Optical Reponse Open
This paper is a review of the scientific works of the co-authors. In the paper, the basic principles of action of sensor systems with optical response of two types are considered. In particular, two spectroscopic technologies for probing s…
View article: Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells
Silent Death by Sound: C60 Fullerene Sonodynamic Treatment of Cancer Cells Open
The acoustic pressure waves of ultrasound (US) penetrate biological tissues deeper than light. Another important feature of US its potential to generate light emission within the excited medium termed sonoluminescence. This promoted the id…
View article: Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer
Drug delivery with a pH-sensitive star-like dextran-graft polyacrylamide copolymer Open
The development of precision cancer medicine relies on novel formulation strategies for targeted drug delivery to increase the therapeutic outcome.
View article: CCDC 1556064: Experimental Crystal Structure Determination
CCDC 1556064: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo
Antitumor efficiency of the natural alkaloid berberine complexed with C60 fullerene in Lewis lung carcinoma in vitro and in vivo Open
Background Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and a high anticancer potency in particular. However, due to its low bioavailability, the difficulty in reaching a target and choosing the right dose,…
View article: Synergistic Chemo- and Photodynamic Treatment of Cancer Cells with C\(_{60}\) Fullerene Nanocomplexes
Synergistic Chemo- and Photodynamic Treatment of Cancer Cells with C\(_{60}\) Fullerene Nanocomplexes Open
Recent progress in nanotechnology has attracted interest to a biomedical application of the carbon nanoparticle C60 fullerene (C60) due to its unique structure and versatile biological activity. In the current study the dual functionality …
View article: C60 Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells
C60 Fullerene as an Effective Nanoplatform of Alkaloid Berberine Delivery into Leukemic Cells Open
A herbal alkaloid Berberine (Ber), used for centuries in Ayurvedic, Chinese, Middle-Eastern, and native American folk medicines, is nowadays proved to function as a safe anticancer agent. Yet, its poor water solubility, stability, and bioa…
View article: Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex
Synergy of Chemo- and Photodynamic Therapies with C60 Fullerene-Doxorubicin Nanocomplex Open
A nanosized drug complex was explored to improve the efficiency of cancer chemotherapy, complementing it with nanodelivery and photodynamic therapy. For this, nanomolar amounts of a non-covalent nanocomplex of Doxorubicin (Dox) with carbon…
View article: A new triple system DNA-Nanosilver-Berberine for cancer therapy
A new triple system DNA-Nanosilver-Berberine for cancer therapy Open
The isoquinoline quaternary alkaloid Berberine possesses a variety of pharmacological properties that suggests its promising application for an anticancer delivery system design utilizing its ability to intercalate DNA. In the current work…