Anna H. Bizard
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View article: Nonlinear mechanics of human mitotic chromosomes
Nonlinear mechanics of human mitotic chromosomes Open
In preparation for mitotic cell division, the nuclear DNA of human cells is compacted into individualized, X-shaped chromosomes 1 . This metamorphosis is driven mainly by the combined action of condensins and topoisomerase IIα (TOP2A) 2,3 …
View article: Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex
Duplex DNA and BLM regulate gate opening by the human TopoIIIα-RMI1-RMI2 complex Open
Topoisomerase IIIα is a type 1A topoisomerase that forms a complex with RMI1 and RMI2 called TRR in human cells. TRR plays an essential role in resolving DNA replication and recombination intermediates, often alongside the helicase BLM. Wh…
View article: Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1
Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1 Open
As cells enter mitosis, chromatin compacts to facilitate chromosome segregation yet remains transcribed. Transcription supercoils DNA to levels that can impede further progression of RNA polymerase II (RNAPII) unless it is removed by DNA t…
View article: The many lives of type IA topoisomerases
The many lives of type IA topoisomerases Open
The double-helical structure of genomic DNA is both elegant and functional in that it serves both to protect vulnerable DNA bases and to facilitate DNA replication and compaction. However, these design advantages come at the cost of having…
View article: Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability
Regulation of ETAA1-mediated ATR activation couples DNA replication fidelity and genome stability Open
The ATR kinase is a master regulator of the cellular response to DNA replication stress. Activation of ATR relies on dual pathways involving the TopBP1 and ETAA1 proteins, both of which harbor ATR-activating domains (AADs). However, the ex…
View article: Mutations in TOP3A Cause a Bloom Syndrome-like Disorder
Mutations in TOP3A Cause a Bloom Syndrome-like Disorder Open
(The American Journal of Human Genetics 103, 221–231; August 2, 2018) In the originally published version of this paper, Alejandro Iglesias’s name was misspelled. It appears correctly here and has been corrected in the paper online. The au…
View article: Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality
Loss of PICH Results in Chromosomal Instability, p53 Activation, and Embryonic Lethality Open
PICH is a DNA translocase necessary for the resolution of ultrafine anaphase DNA bridges and to ensure the fidelity of chromosomal segregation. Here, we report the generation of an animal model deficient for PICH that allowed us to investi…
View article: TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase
TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase Open
DNA topoisomerases are essential enzymes involved in all the DNA processes and among them, type IA topoisomerases emerged as a key actor in the maintenance of genome stability. The hyperthermophilic archaeon, Sulfolobus solfataricus, conta…
View article: A novel TPR–BEN domain interaction mediates PICH–BEND3 association
A novel TPR–BEN domain interaction mediates PICH–BEND3 association Open
PICH is a DNA translocase required for the maintenance of chromosome stability in human cells. Recent data indicate that PICH co-operates with topoisomerase IIα to suppress pathological chromosome missegregation through promoting the resol…