Explanipedia

Management of perioperative iron deficiency anemia as part of patient blood management in France: A budget impact <span>model‐based</span> analysis based on real world data Open

Sigismond Lasocki, D. Delahaye, David Fuks, P.-H. Savoie, Claude Dussart , et al. · 2023

Objectives Patient Blood Management (PBM) is defined as a patient‐centered, systematic, evidence‐based approach to improve patient outcomes by managing and preserving a patient's own blood, while promoting patient safety and empowerment. A…

Patient Blood Management in Liver Transplant—A Concise Review Open

Ángel Augusto Pérez-Calatayud, Axel Hofmann, Antonio Pérez Ferrer, Carla Adelina Escorza-Molina, Bettina Torres-Pérez , et al. · 2023

Transfusion of blood products in orthotopic liver transplantation (OLT) significantly increases post-transplant morbidity and mortality and is associated with reduced graft survival. Based on these results, an active effort to prevent and …

Recommendations From the International Consensus Conference on Anemia Management in Surgical Patients (ICCAMS) Open

Aryeh Shander, Howard L. Corwin, Jens Meier, Michael Auerbach, Elvira Bisbe , et al. · 2022

Background: Perioperative anemia has been associated with increased risk of red blood cell transfusion and increased morbidity and mortality after surgery. The optimal approach to the diagnosis and management of perioperative anemia is not…

Perioperative inappropriate red blood cell transfusions significantly increase total costs in elective surgical patients, representing an important economic burden for hospitals Open

Andrea Saporito, Davide La Regina, Axel Hofmann, Lorenzo Ruinelli, Alessandro Merler , et al. · 2022

Background Red blood cell (RBC) transfusions in surgical patients are associated with increased morbidity a hospital stay. However, little is known about how clinical and economic outcomes differ between appropriately and inappropriately t…

Dissemination of patient blood management practices in Swiss intensive care units: a cross-sectional survey Open

Marco Previsdomini, Jacopo Colombo, Bernard Cerutti, B. Gerber, Axel Hofmann , et al. · 2022

BACKGROUND: Patient blood management (PBM) promotes the routine detection and treatment of anaemia before surgery, optimising the management of bleeding disorders, thus minimising iatrogenic blood loss and pre-empting allogeneic blood util…

Making patient blood management the new norm(al) as experienced by implementors in diverse countries Open

Axel Hofmann, Donat R. Spahn, Anke‐Peggy Holtorf, James P. Isbister, Jeff Hamdorf , et al. · 2021

Iron deficiency in PREVENTT Open

Axel Hofmann, Irwin Gross, Domenico Girelli, Matti Aapro, Donat R. Spahn · 2021

Path to Action – Closing the Gap to Make Patient Blood Management the New Norm(al) as Viewed by Implementors in Diverse Countries Open

Axel Hofmann, Donat R. Spahn, Anke‐Peggy Holtorf · 2020

Background: Patient Blood Management (PBM) is an evidence-based approach in surgery and emergency care which aims to minimize the risk for blood loss and the need for blood replacement for each patient through a coordinated multidisciplina…

Patient blood management in oncology in the Russian Federation: resolution to improve oncology care. Open

Axel Hofmann, Matti Aapro, Т. А. Федорова, Е Б Жибурт, A. V. Snegovoy , et al. · 2020

The huge global burden of oncological diseases is growing and measures to counter this complex challenge are high on national health agendas. The Russian National Long-Term Oncology Strategy 2030 defines priorities, goals and directions in…

A Review of Clinical Guidelines on the Management of Iron Deficiency and Iron-Deficiency Anemia in Women with Heavy Menstrual Bleeding Open

Diana Mansour, Axel Hofmann, Kristina Gemzell‐Danielsson · 2020

Many of the guidelines for managing HMB recognize the importance of treating anemia, but there is a lack of consensus in relation to screening for ID and use of iron therapy. Consequently, ID/IDA associated with HMB is likely to be underdi…

Is patient blood management cost-effective? Comment on Br J Anaesth 2020 Open

Kevin M. Trentino, Donat R. Spahn, Hamish Mace, H. Gombotz, Axel Hofmann · 2020

Screening and treating pre‐operative anaemia and suboptimal iron stores in elective colorectal surgery: a cost effectiveness analysis Open

Kevin M. Trentino, Hamish Mace, Kylie Symons, Frank Sanfilippo, Michael F. Leahy , et al. · 2020

Summary Our study investigated whether pre‐operative screening and treatment for anaemia and suboptimal iron stores in a patient blood management clinic is cost effective. We used outcome data from a retrospective cohort study comparing co…

Machine learning–based prediction of transfusion Open

Andreas Mitterecker, Axel Hofmann, Kevin M. Trentino, Adam Lloyd, Michael F. Leahy , et al. · 2020

Background The ability to predict transfusions arising during hospital admission might enable economized blood supply management and might furthermore increase patient safety by ensuring a sufficient stock of red blood cells (RBCs) for a s…

Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: an overview of systematic reviews Open

Kevin M. Trentino, Shannon L. Farmer, Michael F. Leahy, Frank Sanfilippo, James P. Isbister , et al. · 2020

Essential Role of Patient Blood Management in a Pandemic: A Call for Action Open

Aryeh Shander, Susan M. Goobie, Matthew A. Warner, Matti Aapro, Elvira Bisbe , et al. · 2020

The World Health Organization (WHO) has declared coronavirus disease 2019 (COVID-19), the disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a pandemic. Global health care now faces unprecedented challenges…

Systematic reviews and meta-analyses comparing mortality in restrictive and liberal haemoglobin thresholds for red cell transfusion: protocol for an overview of systematic reviews Open

Kevin M. Trentino, Shannon L. Farmer, Frank Sanfilippo, Michael F. Leahy, James P. Isbister , et al. · 2019

Introduction There has been a significant increase in the number of systematic reviews and meta-analyses of randomised controlled trials investigating thresholds for red blood cell transfusion. To systematically collate, appraise and synth…

Patient blood management: A solution for South Africa Open

Jackie Thomson, Axel Hofmann, C Barrett, A Beeton, Gregory Bellairs , et al. · 2019

For more than 70 years the default therapy for anaemia and blood loss was mostly transfusion. Accumulating evidence demonstrates a significant dose-dependent relationship between transfusion and adverse outcomes. This and other transfusion…

Getting patient blood management Pillar 1 right in the Asia-Pacific: a call for action Open

Hairil Rizal Abdullah, AL Ang, Bernd Froessler, Axel Hofmann, JH Jang , et al. · 2019

Preoperative anaemia is common in the Asia-Pacific. Iron deficiency anaemia (IDA) is a risk factor that can be addressed under patient blood management (PBM) Pillar 1, leading to reduced morbidity and mortality. We examined PBM implementat…

Associations of nadir haemoglobin level and red blood cell transfusion with mortality and length of stay in surgical specialties: a retrospective cohort study Open

Kevin M. Trentino, Michael F. Leahy, Frank Sanfilippo, Shannon L. Farmer, Axel Hofmann , et al. · 2019

Summary Few studies have investigated if, and how, red cell transfusion and anaemia interact. We analysed 60,955 admissions to three metropolitan hospitals in Western Australia between 2008 and 2017 to determine whether the relationship be…

Corrections to “Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines” Open

Matti Aapro, Yves Béguin, C. Bokemeyer, Mario Dicato, Pere Gascón , et al. · 2018

Ann Oncol 2018; 29: iv96–iv110 (doi:10.1093/annonc/mdx758) The following corrections have been made: In “Table 2. Managing anaemia in patients with MDS” In the last sentence, the word: patient has been replaced with: patients In “Table 4. …

Hepcidin predicts response to IV iron therapy in patients admitted to the intensive care unit: a nested cohort study Open

Edward Litton, Stuart Baker, Wendy N. Erber, Shannon L. Farmer, Janet Ferrier , et al. · 2018

Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines Open

Matti Aapro, Yves Béguin, Carsten Bokemeyer, Mario Dicato, Pere Gascón , et al. · 2017

Development of Multivariable Models to Predict and Benchmark Transfusion in Elective Surgery Supporting Patient Blood Management Open

Dieter Hayn, Karl Kreiner, Hubert Ebner, Peter Kästner, Nada Breznik , et al. · 2017

Summary Background: Blood transfusion is a highly prevalent procedure in hospitalized patients and in some clinical scenarios it has lifesaving potential. However, in most cases transfusion is administered to hemodynamically stable patient…

Posttransfusion Increase of Hematocrit per se Does Not Improve Circulatory Oxygen Delivery due to Increased Blood Viscosity Open

Robert A. Zimmerman, Amy G. Tsai, Beatriz Y. Salazar Vázquez, Pedro Cabrales, Axel Hofmann , et al. · 2017

BACKGROUND: Blood transfusion is used to treat acute anemia with the goal of increasing blood oxygen-carrying capacity as determined by hematocrit (Hct) and oxygen delivery (DO 2 ). However, increasing Hct also increases blood viscosity, w…

Improved outcomes and reduced costs associated with a health‐system–wide patient blood management program: a retrospective observational study in four major adult tertiary‐care hospitals Open

Michael F. Leahy, Axel Hofmann, Simon Towler, Kevin M. Trentino, Sally Burrows , et al. · 2017

BACKGROUND Patient blood management (PBM) programs are associated with improved patient outcomes, reduced transfusions and costs. In 2008, the Western Australia Department of Health initiated a comprehensive health‐system–wide PBM program.…

Gender disparities in red blood cell transfusion in elective surgery: a post hoc multicentre cohort study Open

H. Gombotz, G. Schreier, Stefan Neubauer, Peter Kästner, Axel Hofmann · 2016

Objectives A post hoc gender comparison of transfusion-related modifiable risk factors among patients undergoing elective surgery. Settings 23 Austrian centres randomly selected and stratified by region and level of care. Participants We c…

Critical Role of Iron in Epoetin Alfa Treatment of Chemotherapy-Associated Anemia Open

Irwin Gross, Shannon L. Farmer, Axel Hofmann, Sherri Ozawa, Aryeh Shander , et al. · 2016

In the study by Leyland-Jones et al, 1 we question whether the protocol resulted in adequate iron supplementation in both the epoetin alfa (EPO) group and the best standard of care (BSC) group, but especially in the group that was randomly…

Patient Blood Management Bundles to Facilitate Implementation Open

Patrick Meybohm, Toby Richards, James P. Isbister, Axel Hofmann, Aryeh Shander , et al. · 2016

More than 30% of the world's population are anemic with serious economic consequences including reduced work capacity and other obstacles to national welfare and development. Red blood cell transfusion is the mainstay to correct anemia, bu…

A Programmatic Approach to Patient Blood Management – ReducingTransfusions and Improving Patient Outcomes Open

Shannon L. Farmer, Kevin M. Trentino, Axel Hofmann, James B. Semmens, Syed Aqif Mukhtar , et al. · 2015

In July 2008, the Western Australia (WA) Department of Health embarked on a landmark 5-year project to implement a sustainable comprehensive health-system-wide Patient Blood Management Program. Fundamentally, it was a quality and safety in…

Supra-Plasma Expanders Open

Amy G. Tsai, Beatriz Y. Salazar Vázquez, Axel Hofmann, Seetharama A. Acharya, Marcos Intaglietta · 2015

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise…

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