Aihua Wu
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View article: Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease
Plasma Potassium Negatively Correlates With Sodium Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles From Patients With Chronic Kidney Disease Open
Aim Using urinary extracellular vesicles (uEVs), we have demonstrated the functional ‘renal‐K switch’ mechanism (the WNK‐SPAK‐NCC pathway) in both healthy subjects and those with primary aldosteronism. The close relationship between blood …
View article: Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program
Macrophage SPAK deletion limits a low potassium-induced kidney inflammatory program Open
Global Ste20p-related proline alanine-rich kinase (SPAK) deletion protects against harmful kidney effects of dietary K + deficiency. Exposure to low K + conditions increases SPAK phosphorylation and induces SPAK to adopt a punctate stainin…
View article: Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults
Randomized Trial on the Effect of Oral Potassium Chloride Supplementation on the Thiazide-Sensitive Sodium Chloride Cotransporter in Healthy Adults Open
The lower NCC and pNCC in uEVs in response to oral KCl supplementation provide evidence to support the hypothesis of a functional "renal-K switch" in healthy human subjects.
View article: PS-BPC10-7: EFFECT OF ORAL POTASSIUM CHLORIDE SUPPLEMENTATION ON THE THIAZIDE-SENSITIVE SODIUM CHLORIDE COTRANSPORTER (NCC) IN HEALTHY HUMANS: A RANDOMISED CROSSOVER TRIAL
PS-BPC10-7: EFFECT OF ORAL POTASSIUM CHLORIDE SUPPLEMENTATION ON THE THIAZIDE-SENSITIVE SODIUM CHLORIDE COTRANSPORTER (NCC) IN HEALTHY HUMANS: A RANDOMISED CROSSOVER TRIAL Open
Objective: The putative “renal-K + switch’’ mechanism links low K + intake with Na + -dependent Na + retention and involves activation of NCC in the distal convoluted tubule in response to low K + intake and suppression in response to high…
View article: Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter
Using human urinary extracellular vesicles to study physiological and pathophysiological states and regulation of the sodium chloride cotransporter Open
The thiazide-sensitive sodium chloride cotransporter (NCC), expressed in the renal distal convoluted tubule, plays a major role in Na + , Cl - and K + homeostasis and blood pressure as exemplified by the symptoms of patients with non-funct…
View article: In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter
In Primary Aldosteronism Acute Potassium Chloride Supplementation Suppresses Abundance and Phosphorylation of the Sodium-Chloride Cotransporter Open
Key Points Potassium chloride intake induced a reduction in sodium-chloride cotransporter (NCC) and phosphorylated NCC in urinary extracellular vesicles from patients with primary aldosteronism during a significantly raised level of endoge…
View article: REDUCED NACL COTRANSPORTER ABUNDANCE AND PHOSPHORYLATION IN URINARY EXTRACELLULAR VESICLES IN RESPONSE TO KCL SUPPLEMENTS IN HEALTHY ADULTS MAINTAINED ON A HIGH-NA+ LOW-K+ DIET: A
REDUCED NACL COTRANSPORTER ABUNDANCE AND PHOSPHORYLATION IN URINARY EXTRACELLULAR VESICLES IN RESPONSE TO KCL SUPPLEMENTS IN HEALTHY ADULTS MAINTAINED ON A HIGH-NA+ LOW-K+ DIET: A Open
Objective: A renal-K switch mechanism has been established in rodent models and demonstrates that a low K+ intake acts as a trigger that links K+ and Na+-dependent blood pressure. This mechanism involves activation (phosphorylation) of the…
View article: Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles
Acute Intravenous NaCl and Volume Expansion Reduces Sodium-Chloride Cotransporter Abundance and Phosphorylation in Urinary Extracellular Vesicles Open
Key Points Volume expansion induced a clear reduction in aquaporin 2 abundance in urinary extracellular vesicles. Changes in sodium-chloride cotransporter (NCC) and phosphorylated NCC may have been primarily due to diluted post-test urine …
View article: Secretory Pathway Kinase FAM20C, a Marker for Glioma Invasion and Malignancy, Predicts Poor Prognosis of Glioma
Secretory Pathway Kinase FAM20C, a Marker for Glioma Invasion and Malignancy, Predicts Poor Prognosis of Glioma Open
Shaonan Du,1 Shu Guan,2 Chen Zhu,1 Qing Guo,1 Jingyuan Cao,1 Gefei Guan,1 Wen Cheng,1 Peng Cheng,1 Anhua Wu1,3 1Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, People’s Republic of China; 2Depart…
View article: IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma
IFI30 Is a Novel Immune-Related Target with Predicting Value of Prognosis and Treatment Response in Glioblastoma Open
Chen Zhu,* Xin Chen,* Gefei Guan, Cunyi Zou, Qing Guo, Peng Cheng, Wen Cheng, Anhua Wu Department of Neurosurgery, The First Hospital of China Medical University, Shenyang, Liaoning, People’s Republic of China*These authors contribut…
View article: Supplementary Material for: Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort
Supplementary Material for: Sequential Systemic Treatment in Advanced Hepatocellular Carcinoma Is Able to Prolong Median Survival to More than 3 Years in a Selected Real-World Cohort Open
Introduction: The number of efficacious systemic agents for advanced hepatocellular carcinoma (HCC) has rapidly increased over the past 3 years. However, guidance for optimal sequential systemic treatment in patients with advanced disease …
View article: New opinion on the subtypes of poststroke depression in Chinese stroke survivors
New opinion on the subtypes of poststroke depression in Chinese stroke survivors Open
Yingying Yue,1,2 Rui Liu,3 Yin Cao,4 Yanfeng Wu,5 Shining Zhang,6 Huajie Li,7 Jijun Zhu,8 Wenhao Jiang,1,2 Aiqin Wu,9 Yonggui Yuan1,2 1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University,…
View article: In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance
In Primary Aldosteronism, Mineralocorticoids Influence Exosomal Sodium-Chloride Cotransporter Abundance Open
Distal tubular sodium retention is a potent driver of hypertension, and the thiazide–sensitive sodium-chloride cotransporter (NCC) has a key role in this process. In humans, factors regulating NCC are unclear, but in animal models, aldoste…
View article: Antitumor activity of pluripotent cell-engineered vaccines and their potential to treat lung cancer in relation to different levels of irradiation
Antitumor activity of pluripotent cell-engineered vaccines and their potential to treat lung cancer in relation to different levels of irradiation Open
Yan-na Zhang, Xiao-gang Duan, Wen-hui Zhang, Ai-ling Wu, Huan-Huan Yang, Dong-ming Wu, Yu-Quan Wei, Xian-cheng Chen State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical …