Anna J. Stevenson
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View article: Health impact assessments should be mandatory for all relevant government policies
Health impact assessments should be mandatory for all relevant government policies Open
Consistent and systematic integration of health considerations in upstream political decision making is needed to improve population health and enhance health equity. Previous research supports the effectiveness of Health Impact Assessment…
View article: Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination
Systematic review of evidence for the impact and effectiveness of the 1-3-7 strategy for malaria elimination Open
Background The 1-3-7 approach to eliminate malaria was first implemented in China in 2012. It has since been expanded to multiple countries, but no systematic review has examined the evidence for its use. A systematic review was conducted …
View article: Surgical and transcatheter aortic valve interventions for aortic stenosis in England: sociodemographic variations in treatment trends and outcome over 20 years
Surgical and transcatheter aortic valve interventions for aortic stenosis in England: sociodemographic variations in treatment trends and outcome over 20 years Open
Background Health inequalities in cardiovascular care have been identified in the UK. The sociodemographic characteristics of patients undergoing intervention for aortic stenosis (AS) in England, and the impact of COVID-19, is unknown. Met…
View article: COVID-19 risk by work-related factors: pooled analysis of individual linked data from 14 cohorts
COVID-19 risk by work-related factors: pooled analysis of individual linked data from 14 cohorts Open
Background SARS-CoV-2 infection rates vary by occupation, but the association with work-related characteristics (such as home working, keyworker or furlough) are not fully understood and may depend on ascertainment approach. We assessed in…
View article: Epigenetic scores derived in saliva are associated with gestational age at birth
Epigenetic scores derived in saliva are associated with gestational age at birth Open
View article: Ignoring and collective passivity in relation to information systems: How actors avoided engagement with data about wait times in Swedish healthcare
Ignoring and collective passivity in relation to information systems: How actors avoided engagement with data about wait times in Swedish healthcare Open
Although digital technology (DT) is often introduced with the aim of enhancing organizational knowledge transfer and learning, these aims often fail to materialize. The information systems (IS) literature attributes such unexpected outcome…
View article: MiniMovers: An Initial Pilot and Feasibility Study to Investigate the Impact of a Mobile Application on Children’s Motor Skills and Parent Support for Physical Development
MiniMovers: An Initial Pilot and Feasibility Study to Investigate the Impact of a Mobile Application on Children’s Motor Skills and Parent Support for Physical Development Open
The MiniMovers (MM) APP combines motor development theory with creativity expertise and has been designed to provide parents with developmentally appropriate activities to support children’s motor skills. This study investigates how MiniMo…
View article: MiniMovers: An initial pilot and feasibility study to investigate the impact of a mobile application on children’s motor skills and parent support for physical development
MiniMovers: An initial pilot and feasibility study to investigate the impact of a mobile application on children’s motor skills and parent support for physical development Open
The MiniMovers (MM) APP combines motor development theory with creativity expertise and has been designed to provide parents with developmentally appropriate activities to support children’s motor skills. This study investigates how MiniMo…
View article: Epigenetic scores indicate differences in the proteome of preterm infants
Epigenetic scores indicate differences in the proteome of preterm infants Open
Background Epigenetic scores (EpiScores), reflecting DNA methylation (DNAm)-based surrogates for complex traits, have been developed for multiple circulating proteins. EpiScores for pro-inflammatory proteins, such as C-reactive protein (DN…
View article: Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts
Covid-19 Risk by work-related factors: Pooled analysis of individual linked data from 14 cohorts Open
Background SARS-CoV-2 infection rates vary by occupation, but the association with work-related characteristics (such as home working, key-worker, or furlough) are not fully understood and may depend on ascertainment approach. We assessed …
View article: Correction: Epigenetic scores for the circulating proteome as tools for disease prediction
Correction: Epigenetic scores for the circulating proteome as tools for disease prediction Open
View article: Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8
Human astrocytes and microglia show augmented ingestion of synapses in Alzheimer’s disease via MFG-E8 Open
Synapse loss correlates with cognitive decline in Alzheimer's disease (AD). Data from mouse models suggests microglia are important for synapse degeneration, but direct human evidence for any glial involvement in synapse removal in human A…
View article: Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders
Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders Open
Inflammatory-related DNAm captures the allostatic load of inflammatory burden in preterm infants. Such DNAm measures complement biological and clinical metrics when investigating the determinants of neurodevelopmental differences.
View article: Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders
Immuno-epigenetic signature derived in saliva associates with the encephalopathy of prematurity and perinatal inflammatory disorders Open
Background Preterm birth is closely associated with a phenotype that includes brain dysmaturation and neurocognitive impairment, commonly termed Encephalopathy of Prematurity (EoP), of which systemic inflammation is considered a key driver…
View article: Inequalities in healthcare disruptions during the COVID-19 pandemic: evidence from 12 UK population-based longitudinal studies
Inequalities in healthcare disruptions during the COVID-19 pandemic: evidence from 12 UK population-based longitudinal studies Open
Objectives We investigated associations between multiple sociodemographic characteristics (sex, age, occupational social class, education and ethnicity) and self-reported healthcare disruptions during the early stages of the COVID-19 pande…
View article: The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys
The UK Coronavirus Job Retention Scheme and smoking, alcohol consumption and vaping during the COVID-19 pandemic: evidence from eight longitudinal population surveys Open
View article: Correction: The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys
Correction: The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys Open
View article: RuralCovidLife: A new resource for the impact of the pandemic on rural Scotland.
RuralCovidLife: A new resource for the impact of the pandemic on rural Scotland. Open
RuralCovidLife is part of Generation Scotland’s CovidLife project, investigating the impact of the COVID-19 pandemic and mitigation measures on people in Scotland. The RuralCovidLife project focuses on Scotland’s rural communities, and how…
View article: The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys
The UK Coronavirus Job Retention Scheme and diet, physical activity, and sleep during the COVID-19 pandemic: evidence from eight longitudinal population surveys Open
View article: A comparison of blood and brain‐derived ageing and inflammation‐related DNA methylation signatures and their association with microglial burdens
A comparison of blood and brain‐derived ageing and inflammation‐related DNA methylation signatures and their association with microglial burdens Open
Inflammation and ageing‐related DNA methylation patterns in the blood have been linked to a variety of morbidities, including cognitive decline and neurodegenerative disease. However, it is unclear how these blood‐based patterns relate to …
View article: Epigenetic scores for the circulating proteome as tools for disease prediction
Epigenetic scores for the circulating proteome as tools for disease prediction Open
Protein biomarkers have been identified across many age-related morbidities. However, characterising epigenetic influences could further inform disease predictions. Here, we leverage epigenome-wide data to study links between the DNA methy…
View article: Rethinking embeddedness: a review and research agenda
Rethinking embeddedness: a review and research agenda Open
We conduct a comprehensive review of embeddedness in entrepreneurship research. Although the term “embeddedness” is frequently used in this field of study, less is known about the ways in which it is operationalized and applied. Using crit…
View article: ‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts
‘Inflammaging’ in Major Depressive Disorder: Associations between markers of inflammation and brain ageing in depression across two large community-based cohorts Open
Background Major Depressive Disorder (MDD) is associated with accelerated ageing trajectories including functional markers of ageing, cellular ageing and markers of poor brain health. The biological mechanisms underlying these associations…
View article: Author response: Epigenetic scores for the circulating proteome as tools for disease prediction
Author response: Epigenetic scores for the circulating proteome as tools for disease prediction Open
Article Figures and data Abstract Editor's evaluation eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Protein b…
View article: RuralCovidLife: Study protocol and description of the data
RuralCovidLife: Study protocol and description of the data Open
RuralCovidLife is part of Generation Scotland’s CovidLife project, investigating the impact of the COVID-19 pandemic and mitigation measures on people in Scotland. The RuralCovidLife project focuses on Scotland’s rural communities, and how…
View article: DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging
DNA Methylation and Protein Markers of Chronic Inflammation and Their Associations With Brain and Cognitive Aging Open
This study provides Class II evidence that a DNAm signature of CRP levels is more strongly associated with brain health outcomes than serum CRP levels.
View article: The UK COVID-19 furlough scheme and associations with smoking, alcohol consumption and vaping: evidence from 8 UK longitudinal population surveys
The UK COVID-19 furlough scheme and associations with smoking, alcohol consumption and vaping: evidence from 8 UK longitudinal population surveys Open
Background Disruptions to employment status can impact smoking and alcohol consumption. During the COVID-19 pandemic, the UK implemented a furlough scheme to prevent job loss. We examine how furlough was associated with participants’ smoki…
View article: Pre-pandemic mental health and disruptions to healthcare, economic and housing outcomes during the COVID-19 pandemic: evidence from 12 UK longitudinal studies
Pre-pandemic mental health and disruptions to healthcare, economic and housing outcomes during the COVID-19 pandemic: evidence from 12 UK longitudinal studies Open
Background The COVID-19 pandemic has disrupted lives and livelihoods, and people already experiencing mental ill health may have been especially vulnerable. Aims Quantify mental health inequalities in disruptions to healthcare, economic ac…
View article: Investigating the relationship between inflammation, DNA methylation and cognitive ability
Investigating the relationship between inflammation, DNA methylation and cognitive ability Open
Maintenance of cognitive function in older age is becoming increasingly relevant due to the ageing population and the personal and socioeconomic consequences associated with cognitive decline and dementia. Identification of the determinant…
View article: Inequalities in healthcare disruptions during the Covid-19 pandemic: Evidence from 12 UK population-based longitudinal studies
Inequalities in healthcare disruptions during the Covid-19 pandemic: Evidence from 12 UK population-based longitudinal studies Open
Background Health systems worldwide have faced major disruptions due to COVID-19 which could exacerbate health inequalities. The UK National Health Service (NHS) provides free healthcare and prioritises equity of delivery, but the pandemic…