Anna Kelemen
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View article: Closed-Loop, Subgaleal Intersectional Short-Pulse Stimulation for the Treatment of Therapy-Resistant Epilepsy in Adults
Closed-Loop, Subgaleal Intersectional Short-Pulse Stimulation for the Treatment of Therapy-Resistant Epilepsy in Adults Open
One-third of epilepsy patients do not fully respond to antiseizure medications (ASM), are not candidates for curative surgical interventions, or have unsuccessful surgical therapies. Safe and effective therapies remain limited for these tr…
View article: Neurologists' perspectives on <scp>SUDEP</scp> communication: A comparative study across five European countries
Neurologists' perspectives on <span>SUDEP</span> communication: A comparative study across five European countries Open
Objectives The leading cause of epilepsy mortality is Sudden unexpected death in epilepsy (SUDEP). National and international guidelines recommend that people with epilepsy are counseled on SUDEP risk at the point of diagnosis or at the ea…
View article: The awareness, attitudes and knowledge of neurologists in Hungary on sudden unexpected death in epilepsy (SUDEP)
The awareness, attitudes and knowledge of neurologists in Hungary on sudden unexpected death in epilepsy (SUDEP) Open
Despite well established guidelines asserting the need to discuss SUDEP with all PWE, epilepsy professionals in Hungary are not doing so. This is consistent with other European countries on the same subject.
View article: Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting: A Prospective, Observational Study in Europe
Effectiveness During 12-Month Adjunctive Brivaracetam Treatment in Patients with Focal-Onset Seizures in a Real-Life Setting: A Prospective, Observational Study in Europe Open
Adjunctive BRV was effective in clinical practice in patients with predominantly difficult-to-treat FOS, as shown by BRV retention rate of 57.7% at 12 months, which is in line with real-world retention rates for other new-generation ASMs.
View article: Multicenter retrospective study of patients with PCDH19‐related epilepsy: The first Hungarian cohort
Multicenter retrospective study of patients with PCDH19‐related epilepsy: The first Hungarian cohort Open
Objective PCDH19‐related epilepsy occurs predominantly in girls and is caused by pathogenic variant of the protocadherin‐19 gene. The initial seizures usually develop in association with fever, begin on average at 15 months of age, and oft…
View article: Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients
Prolongation of cortical sleep spindles during hippocampal interictal epileptiform discharges in epilepsy patients Open
Objective Memory deficits are frequent among patients with epilepsies affecting the temporal lobe. Hippocampal interictal epileptic discharges (hIEDs), the presumed epileptic exaggeration of sharp wave‐ripples (SWRs), are known to contribu…
View article: PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis
PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis Open
The aim of our prospective study was to evaluate the clinical impact of hybrid [18F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]-FDG PET/MRI) on the decision workflow of epileptic patients with discord…
View article: Whole Exome Sequencing in a Series of Patients with a Clinical Diagnosis of Tuberous Sclerosis Not Confirmed by Targeted TSC1/TSC2 Sequencing
Whole Exome Sequencing in a Series of Patients with a Clinical Diagnosis of Tuberous Sclerosis Not Confirmed by Targeted TSC1/TSC2 Sequencing Open
Background: Approximately fifteen percent of patients with tuberous sclerosis complex (TSC) phenotype do not have any genetic disease-causing mutations which could be responsible for the development of TSC. The lack of a proper diagnosis s…
View article: A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures
A Phase 2 Randomized Controlled Trial of the Efficacy and Safety of Cannabidivarin as Add-on Therapy in Participants with Inadequately Controlled Focal Seizures Open
Objective: We assessed the efficacy, safety, and tolerability of cannabidivarin (CBDV) as add-on therapy in adults with inadequately controlled focal seizures. Materials and Methods: One hundred and sixty-two participants (CBDV n=81; place…
View article: The Role of Hybrid FDG-PET/MRI on Decision-Making in Presurgical Evaluation of Drug-Resistant Epilepsy.
The Role of Hybrid FDG-PET/MRI on Decision-Making in Presurgical Evaluation of Drug-Resistant Epilepsy. Open
Background: When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60-90 % to 20-65 %). Hybrid FDG-PET/MRI may provide additional information …
View article: Low‐grade epilepsy‐associated tumour management with or without presurgical evaluation: a multicentre, retrospective, observational study of postsurgical epilepsy outcome
Low‐grade epilepsy‐associated tumour management with or without presurgical evaluation: a multicentre, retrospective, observational study of postsurgical epilepsy outcome Open
Aims Low‐grade epilepsy‐associated neuroepithelial tumours (LEATs) encompass the broad spectrum of tumours associated with epilepsy. Since the postsurgical seizure outcome in LEATs is favourable, it is speculated that epileptological presu…
View article: Lamotrigine Induces Tremor among Epilepsy Patients Probably via Cerebellar Pathways
Lamotrigine Induces Tremor among Epilepsy Patients Probably via Cerebellar Pathways Open
Lamotrigine, a frequently used antiepileptic drug, inhibits voltage-gated sodium-channels. By suppressing the release of glutamate and aspartate, lamotrigine acts as a membrane stabilizer, and it is also effective in bipolar disorder and m…
View article: Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study
Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study Open
Calm Mom is a promising technology for providing theoretically driven behavioral intervention strategies during real-life stressful moments among a highly vulnerable population. Future research efforts will involve addressing technology ch…
View article: Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study
Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study Open
1.7 Among women aged 15-19, rates of pregnancy, birth and abortion; and abortion ratios, by race, and by race and ethnicity
View article: Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study (Preprint)
Theoretically-Based Emotion Regulation Strategies Using a Mobile App and Wearable Sensor Among Homeless Adolescent Mothers: Acceptability and Feasibility Study (Preprint) Open
BACKGROUND Many adolescent mothers are parenting young children under highly stressful conditions as they are managing first-time parenthood, poverty, lack of housing, school and work, and challenging peer and familial relationships. Mobi…
View article: Interictal Epileptiform Activity in the Foramen Ovale Electrodes of a Frontotemporal Dementia Patient
Interictal Epileptiform Activity in the Foramen Ovale Electrodes of a Frontotemporal Dementia Patient Open
Frontotemporal dementia (FTD) is a frequent cause of cognitive decline. While epilepsy is an important comorbidity of Alzheimer’s disease, we lack studies on its presence in FTD. We report on an FTD patient with transient, short-term chang…
View article: Current standards of neuropsychological assessment in epilepsy surgery centers across Europe
Current standards of neuropsychological assessment in epilepsy surgery centers across Europe Open
Summary We explored the current practice with respect to the neuropsychological assessment of surgical epilepsy patients in European epilepsy centers, with the aim of harmonizing and establishing common standards. Twenty‐six epilepsy cente…
View article: Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe
Current use of imaging and electromagnetic source localization procedures in epilepsy surgery centers across Europe Open
Summary Objective In 2014 the European Union–funded E‐ PILEPSY project was launched to improve awareness of, and accessibility to, epilepsy surgery across Europe. We aimed to investigate the current use of neuroimaging, electromagnetic sou…
View article: NREM-sleep Associated Epileptiform Discharges Disappeared Following a Shift toward the Paleolithic Ketogenic Diet in a Child with Extensive Cortical Malformation
NREM-sleep Associated Epileptiform Discharges Disappeared Following a Shift toward the Paleolithic Ketogenic Diet in a Child with Extensive Cortical Malformation Open
Purpose: Although the classical ketogenic diet is an effective treatment in childhood epilepsy, it is difficult to maintain on the long term due to side-effects and dislike. Methods: Here we report a case of a child with frequent epileptif…
View article: <scp>LGI</scp>Proteins and Epilepsy in Human and Animals
<span>LGI</span>Proteins and Epilepsy in Human and Animals Open
Leucine‐rich glioma‐inactivated ( LGI ) protein was first thought to have a suppressor effect in the formation of some cancers. Developments in physiology and medicine made it possible to characterize the function of the LGI protein family…