Asia Sikora Kessler
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View article: Episodic and Long-Term Costs of Acute Pancreatitis Requiring Hospitalization among Adults in US Clinical Practice
Episodic and Long-Term Costs of Acute Pancreatitis Requiring Hospitalization among Adults in US Clinical Practice Open
Objectives: Acute pancreatitis (AP) is associated with significant morbidity and mortality. While most patients fully recover following the acute phase of illness, some develop long-term complications. The objective of this study was to es…
View article: Prevention and treatment of hypertriglyceridemia-mediated acute pancreatitis: A narrative review
Prevention and treatment of hypertriglyceridemia-mediated acute pancreatitis: A narrative review Open
Acute pancreatitis can result in death or serious consequences including chronic pancreatitis, diabetes mellitus, and organ failure. Causes of acute pancreatitis include gallstones, alcohol, and severe hypertriglyceridemia (triglyceride le…
View article: Rates of acute pancreatitis and cardiovascular events among adults with severe or extreme hypertriglyceridemia in US clinical practice
Rates of acute pancreatitis and cardiovascular events among adults with severe or extreme hypertriglyceridemia in US clinical practice Open
Background Severe and extreme hypertriglyceridemia (sHTG [TG 500–879 mg/dL; 5.65–9.93 mmol/L]; eHTG [TG ≥ 880 mg/dL; ≥ 9.94 mmol/L]) are important risk factors for acute pancreatitis (AP) and cardiovascular (CV) events. The objective of th…
View article: Patient experience with familial chylomicronemia syndrome before and after olezarsen treatment: Qualitative interviews with clinical trial participants
Patient experience with familial chylomicronemia syndrome before and after olezarsen treatment: Qualitative interviews with clinical trial participants Open
Results of this qualitative study underscore the significant burden of FCS and support the effectiveness of olezarsen from the patient perspective.
View article: Mapping and Linking between the EQ-5D-5L and the PROMIS Domains in the United States
Mapping and Linking between the EQ-5D-5L and the PROMIS Domains in the United States Open
Objectives The EQ-5D-5L and Patient-Reported Outcomes Measurement Information System (PROMIS®) preference score (PROPr) are preference-based measures. This study compares mapping and linking approaches to align the PROPr and the PROMIS dom…
View article: A qualitative study to explore the patient experience of hypertriglyceridemia-related acute pancreatitis
A qualitative study to explore the patient experience of hypertriglyceridemia-related acute pancreatitis Open
HTG-AP has a substantial symptomatic and HRQoL burden during episodes, which can persist postrecovery. Treatments that reduce the incidence of HTG-AP have potential to improve HRQoL.
View article: 5129 Symptoms and Impacts of Hypertriglyceridemia-related Acute Pancreatitis: A Qualitative Study of the Patient Experience
5129 Symptoms and Impacts of Hypertriglyceridemia-related Acute Pancreatitis: A Qualitative Study of the Patient Experience Open
Disclosure: A. Sikora Kessler: Employee; Self; Ionis Pharmaceuticals Inc.. Stock Owner; Self; Ionis Pharmaceuticals Inc. D.A. Aggio: Other; Self; Daniel Aggio is an employee of Acaster Lloyd Consulting Ltd. and may hold stock or stock opti…
View article: Cross-Sectional Quantitative Evaluation of a Novel Patient-Reported Outcome Measure in Familial Chylomicronemia Syndrome
Cross-Sectional Quantitative Evaluation of a Novel Patient-Reported Outcome Measure in Familial Chylomicronemia Syndrome Open
BACKGROUND: Familial chylomicronemia syndrome (FCS) is a rare metabolic disorder that impacts physical, emotional, social, and cognitive functioning. The FCS-Symptom and Impact Scale (FCS-SIS) patient-reported outcome (PRO) measure assesse…
View article: FRI090 Patterns Of Triglyceride Testing And Results Over Time Among Patients With Diabetes And Severe Hypertriglyceridemia In US Clinical Practice
FRI090 Patterns Of Triglyceride Testing And Results Over Time Among Patients With Diabetes And Severe Hypertriglyceridemia In US Clinical Practice Open
Disclosure: E. Kutrieb: Consulting Fee; Self; Ionis Pharmaceuticals Inc. S.J. Baum: Advisory Board Member; Self; Altimmune, Amgen Inc, Axcella, Boehringer Ingelheim, Eli Lilly & Company, Esperion, Madrigal Pharmaceuticals, Novartis Pharmac…
View article: Changes in Clinical Management of Patients with Schizophrenia Treated with Long-Acting Injectable Antipsychotics (LAIs), Including Telepsychiatry Use, During the COVID-19 Pandemic
Changes in Clinical Management of Patients with Schizophrenia Treated with Long-Acting Injectable Antipsychotics (LAIs), Including Telepsychiatry Use, During the COVID-19 Pandemic Open
Changes made by sites after the pandemic onset were viewed by almost all participants as satisfactory for maintaining standard of care. Almost all participants thought that the use of telepsychiatry services would continue after the pandem…
View article: <p>Antipsychotic Treatment Experiences of People with Schizophrenia: Patient Perspectives from an Online Survey</p>
Antipsychotic Treatment Experiences of People with Schizophrenia: Patient Perspectives from an Online Survey Open
Most participants reported improvements in schizophrenia symptoms associated with the use of APs. However, most participants also reported experiencing numerous bothersome side effects that negatively impacted their work, social functionin…
View article: Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis
Inotersen preserves or improves quality of life in hereditary transthyretin amyloidosis Open
Objective To examine the impact on quality of life (QOL) of patients with hATTR amyloidosis with polyneuropathy treated with inotersen (Tegsedi™) versus placebo. Methods Data were from the NEURO-TTR trial (ClinicalTrials.gov Identifier: NC…
View article: Burden of hereditary transthyretin amyloidosis on quality of life
Burden of hereditary transthyretin amyloidosis on quality of life Open
Introduction Hereditary transthyretin (hATTR) amyloidosis is a progressive, degenerative disease, with peripheral neuropathy, cardiomyopathy, and other clinical manifestations. In this study we examine the impact of hATTR amyloidosis on qu…
View article: The Association of Exposure to Point-of-Sale Tobacco Marketing with Quit Attempt and Quit Success: Results from a Prospective Study of Smokers in the United States
The Association of Exposure to Point-of-Sale Tobacco Marketing with Quit Attempt and Quit Success: Results from a Prospective Study of Smokers in the United States Open
The aim was to assess the association of exposure to point-of-sale (POS) tobacco marketing with quit attempt and quit success in a prospective study of smokers in the United States. Data were collected via telephone-interview on exposure t…