Anna E. King
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View article: Physical activity and blood‐based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)
Physical activity and blood‐based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) Open
Background With three Lancet Commissions finding an increasing proportion of dementia cases could be prevented through lifestyle modification, there are now 14 modifiable risk factors accounting for approximately 45% of all cases. Physical…
View article: Worsened axonal injury and gliosis following diffuse brain injury in male and female mice with neurofilament light gene deletion
Worsened axonal injury and gliosis following diffuse brain injury in male and female mice with neurofilament light gene deletion Open
Neurofilaments have been theorized to make neurons more vulnerable to damage with injury or disease. To investigate how neurofilaments influence traumatic brain injury (TBI) pathophysiology, we examined neuropathology and glial response in…
View article: Independent Effects of Biological Sex and <scp>SARM1</scp> Deletion on Glia Following Diffuse Traumatic Brain Injury
Independent Effects of Biological Sex and <span>SARM1</span> Deletion on Glia Following Diffuse Traumatic Brain Injury Open
Neuroinflammation mediated by microglia and astrocytes is a major component of traumatic brain injury (TBI) pathophysiology. The sterile alpha and TIR motif containing 1 (SARM1) protein has been identified to play a key role in neurodegene…
View article: The Tasmania-London protocol to detect isolated rapid eye movement sleep behavior disorder using home-based video-polysomnography
The Tasmania-London protocol to detect isolated rapid eye movement sleep behavior disorder using home-based video-polysomnography Open
Study Objectives Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is an early manifestation of alpha-synuclein-related neurodegenerative diseases (NDD). There is an average delay in iRBD diagnosis of 9 years from the onset …
View article: The Effect of 6‐Week Advanced Oral Care on Oral Microbiome and Mycobiome Composition in People With Dementia Living in Residential Aged Care
The Effect of 6‐Week Advanced Oral Care on Oral Microbiome and Mycobiome Composition in People With Dementia Living in Residential Aged Care Open
Objectives Oral health is an important aspect of quality of life for older people, especially those with dementia. The impact of an active oral hygiene program on the oral microbiome was explored in a group of older participants (average a…
View article: Are We Asking the Right Questions? Sex Specificity of Dream Characteristics in Probable Rapid Eye Movement Sleep Behavior Disorder
Are We Asking the Right Questions? Sex Specificity of Dream Characteristics in Probable Rapid Eye Movement Sleep Behavior Disorder Open
Background Dream enactment behavior is a common feature of rapid eye movement (REM) sleep behavior disorder (RBD); however, there has been surprisingly little focus on sex differences in dream characterization in RBD. This is important to …
View article: Digitised hand movement and plasma NfL are complementary biomarkers of the dementia continuum
Digitised hand movement and plasma NfL are complementary biomarkers of the dementia continuum Open
BACKGROUNDEmerging research suggests hand motor biomarkers help identify dementia, but it is unclear which test is best, or whether combining with a blood-based biomarker may further improve classification. We evaluated combinations of han…
View article: Physical activity and blood‐based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)
Physical activity and blood‐based biomarkers of neurodegeneration in community dwelling Australians from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) Open
Introduction Physical activity, a key modifiable risk factor for dementia, has been associated with biomarkers of neurodegeneration in the central nervous system, but less is known regarding blood‐based biomarkers. Methods A total of 739 c…
View article: Self-testing for symptoms and signs of prodromal alpha-synucleinopathies: results from the Tasmanian ISLAND Sleep Study
Self-testing for symptoms and signs of prodromal alpha-synucleinopathies: results from the Tasmanian ISLAND Sleep Study Open
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) may occur at least 10 years before a clinical diagnosis of an α-synucleinopathy, such as dementia with Lewy bodies (DLB), Parkinson’s disease (PD) or multiple system atrophy …
View article: Presymptomatic blood tests to detect neurodegeneration: Perceptions of potential consumers across the life course
Presymptomatic blood tests to detect neurodegeneration: Perceptions of potential consumers across the life course Open
INTRODUCTION Recent technological advances have made possible presymptomatic blood testing for neurodegeneration across the life course, though consumer attitudes remain largely unknown. We characterized presymptomatic testing attitudes am…
View article: The Tasmania-London (TASLON) 3-step home-based video-polysomnography approach to detect iRBD in the community: protocol and preliminary results
The Tasmania-London (TASLON) 3-step home-based video-polysomnography approach to detect iRBD in the community: protocol and preliminary results Open
Study Objective: Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is an early manifestation of alpha-synuclein-related neurodegenerative diseases (NDD). There is an average delay in iRBD diagnosis of 9 years showing that w…
View article: Feasibility of computerized motor, cognitive and speech tests in the home: Analysis of TAS Test in 2,300 older adults
Feasibility of computerized motor, cognitive and speech tests in the home: Analysis of TAS Test in 2,300 older adults Open
TAS Test demonstrated high completion rates and user satisfaction across a large community sample, supporting its feasibility as an unsupervised computerized assessment tool. Future research should address demographic representation and te…
View article: ISLAND Campus: a fee-free formal university educational intervention in mid- to later-life to reduce modifiable risk factors for dementia and improve cognition
ISLAND Campus: a fee-free formal university educational intervention in mid- to later-life to reduce modifiable risk factors for dementia and improve cognition Open
Introduction Previous research has tended to focus on early-life education for dementia risk reduction, yet there are great gains for building cognitive reserve in mid- to later-life through educational interventions. ISLAND (Island Study …
View article: Rural‐urban improvements in modifiable risk factors across Tasmania from an online, public health dementia risk reduction initiative: data from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease)
Rural‐urban improvements in modifiable risk factors across Tasmania from an online, public health dementia risk reduction initiative: data from ISLAND (Island Study Linking Ageing and Neurodegenerative Disease) Open
Background People living in diverse rural areas have shown higher rates of Alzheimer’s disease and related dementias (ADRD) compared with their urban counterparts. Further, individuals in rural areas have higher rates of modifiable risk fa…
View article: Impact of free later life formal university education on longitudinal modifiable risk factors, cognition and plasma phosphorylated tau 181
Impact of free later life formal university education on longitudinal modifiable risk factors, cognition and plasma phosphorylated tau 181 Open
Background Previous research has focused on early‐life education to reduce dementia risk, yet there is great potential for enhancing cognitive reserve in later‐life through educational interventions, even for people with low early‐life edu…
View article: Using TAS Test online hand‐tapping tests to detect cognitive decline in a large community cohort of older Australians
Using TAS Test online hand‐tapping tests to detect cognitive decline in a large community cohort of older Australians Open
Background Finding low‐cost, accessible methods to detect people with early‐stage Alzheimer’s disease is a research priority for neuroprotective drug development. Subtle motor impairment of gait occurs years before episodic memory decline …
View article: Unsupervised online reaction time test improves estimation of cognitive function in a large sample of cognitively‐asymptomatic older adults
Unsupervised online reaction time test improves estimation of cognitive function in a large sample of cognitively‐asymptomatic older adults Open
Background Finding low‐cost, accessible methods to detect people at risk of preclinical Alzheimer’s disease (AD) is a research priority for neuroprotective drug development and clinical trials. Sub‐clinical asymptomatic decline in episodic…
View article: Neurofilament heavy phosphorylated epitopes as biomarkers in ageing and neurodegenerative disease
Neurofilament heavy phosphorylated epitopes as biomarkers in ageing and neurodegenerative disease Open
From the day we are born, the nervous system is subject to insult, disease and degeneration. Aberrant phosphorylation states in neurofilaments, the major intermediate filaments of the neuronal cytoskeleton, accompany and mediate many patho…
View article: Vulnerability of neurofilament-expressing neurons in frontotemporal dementia
Vulnerability of neurofilament-expressing neurons in frontotemporal dementia Open
Frontotemporal dementia (FTD) is an umbrella term for several early onset dementias, that are caused by frontotemporal lobar degeneration (FTLD), which involves the atrophy of the frontal and temporal lobes of the brain. Neuron loss in the…
View article: Smartphone automated motor and speech analysis for early detection of Alzheimer's disease and Parkinson's disease: Validation of TapTalk across 20 different devices
Smartphone automated motor and speech analysis for early detection of Alzheimer's disease and Parkinson's disease: Validation of TapTalk across 20 different devices Open
INTRODUCTION Smartphones are proving useful in assessing movement and speech function in Alzheimer's disease and other neurodegenerative conditions. Valid outcomes across different smartphones are needed before population‐level tests are d…
View article: P027 Dream characteristics are sex-specific in REM Sleep Behaviour Disorder and healthy older adults
P027 Dream characteristics are sex-specific in REM Sleep Behaviour Disorder and healthy older adults Open
Introduction REM sleep behaviour disorder (RBD) is strongly associated with neurodegenerative disease (NDD), and the isolated form is a known prodrome of several alpha-synuclein-related NDD’s. RBD is difficult to diagnose, and screening qu…
View article: Alterations to metabolic hormones in amyotrophic lateral sclerosis and frontotemporal dementia postmortem human tissue
Alterations to metabolic hormones in amyotrophic lateral sclerosis and frontotemporal dementia postmortem human tissue Open
Metabolic changes are observed in patients with both amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although regulation of metabolic processes in the CNS is predominantly carried out within the hypothalamus, extra-h…
View article: Experimental laboratory models as tools for understanding modifiable dementia risk
Experimental laboratory models as tools for understanding modifiable dementia risk Open
Experimental laboratory research has an important role to play in dementia prevention. Mechanisms underlying modifiable risk factors for dementia are promising targets for dementia prevention but are difficult to investigate in human popul…
View article: Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum
Development of a smartphone screening test for preclinical Alzheimer’s disease and validation across the dementia continuum Open
Background Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer’s disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD, a 10–20-year period of progressi…
View article: Weight gain-mediated recovery of metabolic and gut microbiome impairments in a TDP-43 mouse model of ALS
Weight gain-mediated recovery of metabolic and gut microbiome impairments in a TDP-43 mouse model of ALS Open
There is increasing interest in the use of hypercaloric diets in patients with the neurodegenerative disease amyotrophic lateral sclerosis (ALS), as gaining weight, and subsequently fat mass, has been associated with better survival in pat…
View article: Modifiable dementia risk factors and AT(N) biomarkers: findings from the EPAD cohort
Modifiable dementia risk factors and AT(N) biomarkers: findings from the EPAD cohort Open
Introduction Modifiable risk factors account for a substantial proportion of Alzheimer’s disease (AD) cases and we currently have a discrete AT(N) biomarker profile for AD biomarkers: amyloid (A), p-tau (T), and neurodegeneration (N). Here…
View article: Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults
Brief webcam test of hand movements predicts episodic memory, executive function, and working memory in a community sample of cognitively asymptomatic older adults Open
INTRODUCTION Low‐cost simple tests for preclinical Alzheimer's disease are a research priority. We evaluated whether remote unsupervised webcam recordings of finger‐tapping were associated with cognitive performance in older adults. METHOD…
View article: Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum
Development of a smartphone screening test for preclinical Alzheimer's disease and validation across the dementia continuum Open
Background Dementia prevalence is predicted to triple to 152 million globally by 2050. Alzheimer's disease (AD) constitutes 70% of cases. There is an urgent need to identify individuals with preclinical AD (a 10–20-year period of progressi…