Anna Kolchinski
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View article: Bridging the Gap: Opsoclonus-Myoclonus Syndrome
Bridging the Gap: Opsoclonus-Myoclonus Syndrome Open
This case of encephalomyelitis in a previously healthy 21-year-old man who developed opsoclonus-myoclonus demonstrates the diagnostic utility of clinically validated metagenomic next-generation sequencing (mNGS), followed by appropriate co…
View article: Encephalitis in Immunocompromised vs Immunocompetent Patients: A Comparative Study
Encephalitis in Immunocompromised vs Immunocompetent Patients: A Comparative Study Open
Background Encephalitis is characterized by brain parenchymal inflammation caused by infection or autoimmunity. There are limited recent data on how immunocompromised patients with encephalitis differ from the general encephalitis populati…
View article: Direct Prediction of 48 Month Survival Status in Patients with Uveal Melanoma Using Deep Learning and Digital Cytopathology Images
Direct Prediction of 48 Month Survival Status in Patients with Uveal Melanoma Using Deep Learning and Digital Cytopathology Images Open
Background: Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. The median overall survival time for patients who develop metastasis is approximately one year. In this study, we aim to leverage deep learning (D…
View article: Absence of Cerebrospinal Fluid Pleocytosis in Encephalitis
Absence of Cerebrospinal Fluid Pleocytosis in Encephalitis Open
Background Early diagnosis of encephalitis involves identifying signs of neuroinflammation, including cerebrospinal fluid (CSF) pleocytosis. However, an absence of CSF pleocytosis in encephalitis has been described, most notably in autoimm…
View article: No drug holidays in BRAFV600E glioma patients: An argument for dose reduction of targeted therapies
No drug holidays in BRAFV600E glioma patients: An argument for dose reduction of targeted therapies Open
Background Combined BRAF and MEK inhibition is effective for some BRAFV600E-altered gliomas, a cancer for which there are few effective therapies. While recent clinical trials demonstrate objective response rates of 30%–40%, tolerable adve…
View article: Plasma biomarkers for brain injury in extracorporeal membrane oxygenation
Plasma biomarkers for brain injury in extracorporeal membrane oxygenation Open
Extracorporeal membrane oxygenation (ECMO) is a life-saving intervention for patients with refractory cardiorespiratory failure. Despite its benefits, ECMO carries a significant risk of neurological complications, including acute brain inj…
View article: Prevalence and Neurological Outcomes of Comatose Patients withExtracorporeal Membrane Oxygenation
Prevalence and Neurological Outcomes of Comatose Patients withExtracorporeal Membrane Oxygenation Open
Background: Coma and disorders of consciousness is understudied in patients on extracorporeal membrane oxygenation (ECMO). The objective of our study was to investigate the prevalence, risk factors, and in-hospital outcomes of comatose ECM…
View article: Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability
Large-scale contractions of Friedreich’s ataxia GAA repeats in yeast occur during DNA replication due to their triplex-forming ability Open
Significance Expansions of GAA repeats cause a severe hereditary neurodegenerative disease, Friedreich’s ataxia. In this study, we characterized the mechanisms of GAA repeat contractions in a yeast experimental system. These mechanisms mig…