Anna Julia Krupa
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View article: The CARE project – study protocol and pilot results from the Polish population
The CARE project – study protocol and pilot results from the Polish population Open
Introduction Negative symptoms of schizophrenia (SZ) are a critical unmet need of SZ treatment. In the past years, clinical tools were developed and guidance papers for the evaluation and management of negative symptoms of SZ were publishe…
View article: Systematic Review of Studies on Group Mindfulness–Based Interventions for Individuals Suffering from Schizophrenia Spectrum Disorders
Systematic Review of Studies on Group Mindfulness–Based Interventions for Individuals Suffering from Schizophrenia Spectrum Disorders Open
Objectives The aim of this study was to determine whether group mindfulness-based interventions (MBIs) offer important support for pharmacological therapy for people suffering from schizophrenia spectrum disorders. Method Searches of elect…
View article: Psychiatric management of fibromyalgia
Psychiatric management of fibromyalgia Open
Fibromyalgia is not a primarily psychogenic disorder, however due to high levels of comorbidity with psychiatric disorders and shared therapeutic targets, psychiatrists can play an important role in the diagnosis and treatment of fibromyal…
View article: Chronotype in individuals with exercise addiction – preliminary analysis
Chronotype in individuals with exercise addiction – preliminary analysis Open
Introduction Exercise addiction (EA) is conceptualized as the uncontrolled practice of physical activity, with repetition of that behavior despite the negative effects on the individual [Khazaal et al. Rev Med Suisse. 2024; 20(882):1354-13…
View article: Hyperactive ADHD symptoms are associated with increased variability in thought content in less constrained contexts
Hyperactive ADHD symptoms are associated with increased variability in thought content in less constrained contexts Open
The current study used two complementary methods to examine whether hyperactive and inattentive ADHD symptoms are differentially linked to thought dynamics under contexts that differ in the extent to which constraints are placed on ongoing…
View article: A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis
A phase 2 randomized trial of safety and pharmacokinetics of IgPro20 and IgPro10 in patients with diffuse cutaneous systemic sclerosis Open
Objectives The primary objective was the safety of s.c. immunoglobulin, IgPro20 (Hizentra, CSL Behring) in adults with dcSSc. Secondary objectives included pharmacokinetics and relative bioavailability of IgPro20, and safety and pharmacoki…
View article: Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder
Trazodone effectiveness in depression: impacts of trazodone extended release vs SSRIs on the health status and quality of life of patients with major depressive disorder Open
Introduction Early research on the pharmacotherapy for major depressive disorder (MDD) has largely focused on symptomatic improvements, whereas this focus has shifted to functioning and quality of life in recent years. Studies have confirm…
View article: Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample
Insulin Resistance, Temperament and Personality Traits Are Associated with Anhedonia in a Transdiagnostic Sample Open
Anhedonia constitutes a core symptom of major depressive disorder (MDD) mediating the ultimate goal of MDD treatment: functional remission. Anhedonia is also present in other clinical populations, including patients with chronic pain. Rece…
View article: Interactions between grapefruit juice and psychotropic medications: an update of the literature and an original case series
Interactions between grapefruit juice and psychotropic medications: an update of the literature and an original case series Open
The impact of GJ on CYP 3A4 appears to be the critical mechanism for the majority of GJ-to-psychopharmacotherapy interactions described in human studies or case reports. However, there are studies and cases of patients clearly showing that…
View article: Consolidating evidence on the role of insulin resistance in major depressive disorder
Consolidating evidence on the role of insulin resistance in major depressive disorder Open
Purpose of review The circular interactions between type 2 diabetes (TMD2) and major depressive disorder (MDD) are well documented but the understanding of their mechanisms has only recently gained more clarity. Latest research indicates, …
View article: TED—trazodone effectiveness in depression: a naturalistic study of the effeciveness of trazodone in extended release formulation compared to SSRIs in patients with a major depressive disorder
TED—trazodone effectiveness in depression: a naturalistic study of the effeciveness of trazodone in extended release formulation compared to SSRIs in patients with a major depressive disorder Open
Introduction: Selective serotonin reuptake inhibitors (SSRIs) are the most often used medications to treat major depressive disorder (MDD). Despite their effectiveness in reducing depressive symptoms, several issues are associated with the…
View article: Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders
Brexpiprazole—Pharmacologic Properties and Use in Schizophrenia and Mood Disorders Open
In 2002, the first III generation antipsychotic drug was registered—aripiprazole. Its partial dopaminergic agonism underlies its unique mechanism of action and the potentially beneficial influence on the positive, negative, or cognitive sy…
View article: Predictors of treatment response to serotonin and noradrenaline reuptake inhibitors in fibromyalgia
Predictors of treatment response to serotonin and noradrenaline reuptake inhibitors in fibromyalgia Open
Increased values of certain clinical and metabolic parameters (BMI, fasting glucose, fasting insulin, HOMA‑IR) as well as the presence of psychiatric comorbidities could affect the response to treatment with SNRIs in the patients with FM.
View article: TED—Trazodone Efficacy in Depression: A Naturalistic Study on the Efficacy of Trazodone in an Extended-Release Formulation Compared to SSRIs in Patients with a Depressive Episode—Preliminary Report
TED—Trazodone Efficacy in Depression: A Naturalistic Study on the Efficacy of Trazodone in an Extended-Release Formulation Compared to SSRIs in Patients with a Depressive Episode—Preliminary Report Open
These are the preliminary results of a 12-week non-randomized, open-label, non-inferiority study comparing the effectiveness of trazodone in an extended-release formulation (XR) versus SSRIs in the treatment of major depressive disorder (M…