Anna Kufner
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View article: Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial
Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial Open
Background Post-stroke pain (PSP) affects nearly half of stroke survivors, severely compromising quality of life. The causes of PSP remain underexplored, although there is likely a complex interplay of lesion effects, psychological factors…
View article: Neuropsychiatric changes following striatal stroke– results from the observational PostPsyDis study
Neuropsychiatric changes following striatal stroke– results from the observational PostPsyDis study Open
Background Ischemic stroke can lead to neuropsychiatric sequelae such as depression and post-traumatic stress disorder (PTSD), resulting in poorer functional outcomes. The POST-stroke PSYchological DIStress PostPsyDis; NCT01187342) study a…
View article: Cerebral Small Vessel Disease and Cognitive Decline Following Transient Ischemic Attack: A Longitudinal Study
Cerebral Small Vessel Disease and Cognitive Decline Following Transient Ischemic Attack: A Longitudinal Study Open
Background Cerebral small vessel disease (CSVD) is a common incidental finding on cerebral MRI in patients with transient ischemic attack (TIA) and stroke and has been linked to increased cerebrovascular risk and cognitive decline. This st…
View article: Lesion Network Mapping of Acute Neurological Deficits and Its Prognostic Value After Ischemic Stroke
Lesion Network Mapping of Acute Neurological Deficits and Its Prognostic Value After Ischemic Stroke Open
LNM-derived scores reflected symptom topography but did not enhance prediction of functional recovery. While promising as a mechanistic tool, the clinical utility of LNM-based damage metrics for prognostication remains limited and requires…
View article: Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke
Fronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke Open
Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level neural substrates of thalamic a…
View article: Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke
Depressive symptoms and anti-N-methyl-D-aspartate-receptor GluN1 antibody seropositivity in the PROSpective cohort with incident stroke Open
Patients with serum NMDAR1-abs (predominantly IgM&IgA) suffer more severe depressive symptoms after mild-to-moderate IS compared to NMDAR1-abs seronegative patients.
View article: Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke
Machine learning-based prediction of clinical outcomes after first-ever ischemic stroke Open
Background Accurate prediction of clinical outcomes in individual patients following acute stroke is vital for healthcare providers to optimize treatment strategies and plan further patient care. Here, we use advanced machine learning (ML)…
View article: Retraction: The smoking paradox in ischemic stroke patients treated with intra-arterial thrombolysis in combination with mechanical thrombectomy–VISTA-Endovascular
Retraction: The smoking paradox in ischemic stroke patients treated with intra-arterial thrombolysis in combination with mechanical thrombectomy–VISTA-Endovascular Open
After this article [1] was published, the authors became aware of a dataset error that renders the article's conclusions invalid.Specifically, due to data labelling and missing information issues, the 'IAT' data reflect intra-arterial (IA)…
View article: Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke
Associations of clonal hematopoiesis with recurrent vascular events and death in patients with incident ischemic stroke Open
Clonal hematopoiesis (CH) is common among older people and is associated with an increased risk of atherosclerosis, inflammation, and shorter overall survival. Age and inflammation are major risk factors for ischemic stroke, yet the associ…
View article: Evolution of Blood-Brain Barrier Permeability in Subacute Ischemic Stroke and Associations With Serum Biomarkers and Functional Outcome
Evolution of Blood-Brain Barrier Permeability in Subacute Ischemic Stroke and Associations With Serum Biomarkers and Functional Outcome Open
Background and Purpose: In the setting of acute ischemic stroke, increased blood-brain barrier permeability (BBBP) as a sign of injury is believed to be associated with increased risk of poor outcome. Pre-clinical studies show that selecte…
View article: No Association Between Thrombus Perviousness and Cardioembolic Stroke Etiology in Basilar Artery Occlusion Stroke
No Association Between Thrombus Perviousness and Cardioembolic Stroke Etiology in Basilar Artery Occlusion Stroke Open
Background: Thrombus perviousness (TP) quantified by thrombus attenuation increase (TAI) assessed on acute non-contrast computed tomography (NCCT) and CT angiography (CTA) may be associated with stroke etiology in anterior circulation isch…
View article: The smoking paradox in ischemic stroke patients treated with intra-arterial thrombolysis in combination with mechanical thrombectomy–VISTA-Endovascular
The smoking paradox in ischemic stroke patients treated with intra-arterial thrombolysis in combination with mechanical thrombectomy–VISTA-Endovascular Open
Background The smoking-paradox of a better outcome in ischemic stroke patients who smoke may be due to increased efficacy of thrombolysis. We investigated the effect of smoking on outcome following endovascular therapy (EVT) with mechanica…
View article: Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke
Magnetic resonance imaging-based changes in vascular morphology and cerebral perfusion in subacute ischemic stroke Open
MRI-based vessel size imaging (VSI) allows for in-vivo assessment of cerebral microvasculature and perfusion. This exploratory analysis of vessel size (VS) and density (Q; both assessed via VSI) in the subacute phase of ischemic stroke inv…
View article: Extent of FLAIR Hyperintense Vessels May Modify Treatment Effect of Thrombolysis: A Post hoc Analysis of the WAKE-UP Trial
Extent of FLAIR Hyperintense Vessels May Modify Treatment Effect of Thrombolysis: A Post hoc Analysis of the WAKE-UP Trial Open
Background and Aims: Fluid-attenuated inversion recovery (FLAIR) hyperintense vessels (FHVs) on MRI are a radiological marker of vessel occlusion and indirect sign of collateral circulation. However, the clinical relevance is uncertain. We…
View article: Association Between Thrombus Perviousness Assessed on Computed Tomography and Stroke Cause
Association Between Thrombus Perviousness Assessed on Computed Tomography and Stroke Cause Open
Background and Purpose: A recent study proposed that thrombus perviousness (TP)—the degree to which contrast agents penetrate the thrombus in an occluded vessel measured on noncontrast computed tomography (NCCT) and CT angiography—may be a…
View article: Two simple and rapid methods based on maximum diameter accurately estimate large lesion volumes in acute stroke
Two simple and rapid methods based on maximum diameter accurately estimate large lesion volumes in acute stroke Open
Background We compared two simple and rapid diameter‐based methods (ABC/2, od‐value) in terms of their accuracy in predicting lesion volume >70 ml and >100 ml. Methods In 238 DWI images of ischemic stroke patients from the AXIS2 trial, max…
View article: Smoking Does Not Alter Treatment Effect of Intravenous Thrombolysis in Mild to Moderate Acute Ischemic Stroke—A Dutch String-of-Pearls Institute (PSI) Stroke Study
Smoking Does Not Alter Treatment Effect of Intravenous Thrombolysis in Mild to Moderate Acute Ischemic Stroke—A Dutch String-of-Pearls Institute (PSI) Stroke Study Open
Background:The smoking-thrombolysis paradox refers to a better outcome in smokers who suffer from acute ischemic stroke (AIS) following treatment with thrombolysis. However, studies on this subject have yielded contradictory results and an…
View article: Smoking does not alter treatment effect of intravenous thrombolysis in mild to moderate acute ischemic stroke – a Dutch String-of-Pearls Institute (PSI) Stoke Study
Smoking does not alter treatment effect of intravenous thrombolysis in mild to moderate acute ischemic stroke – a Dutch String-of-Pearls Institute (PSI) Stoke Study Open
Background The smoking-thrombolysis paradox refers to a better outcome in smokers who suffer from acute ischemic stroke (AIS) following treatment with thrombolysis. However, studies on this subject have yielded contradictory results and an…
View article: MRI measurements BAPTISe (vessel size, density, relative tissue perfusion)
MRI measurements BAPTISe (vessel size, density, relative tissue perfusion) Open
Here we provide three datasets with VSI measurements (vessel size and vessel density) as well as relative tissue perfusion meassurements (rCBV and rCBF) in selected regions of interest (lesion, perilesional space, mirrored lesion) - these …
View article: Current Smoking Does Not Modify the Treatment Effect of Intravenous Thrombolysis in Acute Ischemic Stroke Patients—A Post-hoc Analysis of the WAKE-UP Trial
Current Smoking Does Not Modify the Treatment Effect of Intravenous Thrombolysis in Acute Ischemic Stroke Patients—A Post-hoc Analysis of the WAKE-UP Trial Open
Background: The "smoking paradox" indicates that patients with acute ischemic stroke (AIS) who smoke at the time of their stroke may have a better prognosis after intravenous thrombolysis than non-smokers. However, findings are inconsisten…
View article: PREDICT-STROKE: predicting response to thrombolysis in acute ischemic stroke patients using multiparametric MRI
PREDICT-STROKE: predicting response to thrombolysis in acute ischemic stroke patients using multiparametric MRI Open
Background: Tissue plasminogen activator remains the only licensed pharmaceutical treatment available for acute ischemic stroke. However due to the narrow therapeutic time window, overall rates of thrombolytic intervention are low. Current…
View article: Hyperintense Vessels on FLAIR: Hemodynamic Correlates and Response to Thrombolysis
Hyperintense Vessels on FLAIR: Hemodynamic Correlates and Response to Thrombolysis Open
Hyperintense vessels on FLAIR are associated with larger perfusion deficits, larger infarct growth, and more severe hypoperfusion, suggesting that hyperintense vessels on FLAIR most likely indicate severe ischemia as a result of insufficie…