Anna Kurilovich
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View article: Comprehensive Molecular Characterization of Monomorphic Post-Transplant Lymphoproliferative Disorder (PTLD)
Comprehensive Molecular Characterization of Monomorphic Post-Transplant Lymphoproliferative Disorder (PTLD) Open
Introduction. Post-transplant lymphoproliferative disorder (PTLD) is a rare life-threatening complication that occurs in the setting of iatrogenic immunosuppression after solid organ or hematopoietic stem cell transplantation, often with a…
View article: Longitudinal Molecular Analysis of Tumor Exome and Transcriptome to Evaluate Clonal Evolution and Identify Novel Therapeutic Targets in Thymoma
Longitudinal Molecular Analysis of Tumor Exome and Transcriptome to Evaluate Clonal Evolution and Identify Novel Therapeutic Targets in Thymoma Open
The rarity of thymic epithelial tumors and limited preclinical modeling constrain our understanding of disease biology and the advancement of rational treatment strategies.Tumor mutational profiling has demonstrated sporadic activating mut…
View article: Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma
Preclinical models for prediction of immunotherapy outcomes and immune evasion mechanisms in genetically heterogeneous multiple myeloma Open
The historical lack of preclinical models reflecting the genetic heterogeneity of multiple myeloma (MM) hampers the advance of therapeutic discoveries. To circumvent this limitation, we screened mice engineered to carry eight MM lesions (N…
View article: Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma
Next-generation ALK inhibitors are highly active in ALK-positive large B-cell lymphoma Open
Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma is a rare large B-cell lymphoma subtype that is characterized by a plasmablastic phenotype and an ALK gene fusion. ALK-positive large B-cell lymphoma is resistant to the first…