Amy L. Strong
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View article: 10Investigating the mechanisms of neoadjuvant olaparib and cediranib in renal cancer: results of arms 1 to 3 of the WIndow of opportunity in REnal cancer (WIRE) clinical trial
10Investigating the mechanisms of neoadjuvant olaparib and cediranib in renal cancer: results of arms 1 to 3 of the WIndow of opportunity in REnal cancer (WIRE) clinical trial Open
Background New treatments are required for patients with resistance to current renal cell cancer (RCC) therapies. In contrast to the success of immunotherapy and VEGF directed therapies, few treatments have successfully targeted the RCC ce…
View article: Stochastic Dissipativity for Systems with Probabilistic Input Delays
Stochastic Dissipativity for Systems with Probabilistic Input Delays Open
This work considers stochastic operators in general inner-product spaces, and in particular, systems with stochastically time-varying input delays of a known probability distribution. Stochastic dissipativity and stability are defined from…
View article: Oncological Safety of Autologous Fat Grafting for Breast Reconstruction
Oncological Safety of Autologous Fat Grafting for Breast Reconstruction Open
Background Autologous fat grafting has become a vital component of breast reconstruction. However, concerns remain regarding the safety of fat grafting after oncological resection and breast reconstruction. The purpose of the study was to …
View article: Improved Small-Signal L2 Gain Analysis for Nonlinear Systems
Improved Small-Signal L2 Gain Analysis for Nonlinear Systems Open
TheL2-gain characterizes a dynamical system's input-output properties, but can be difficult to determine for nonlinear systems. Previous work designed a nonconvex optimization problem to simultaneously search for a continuous piecewise aff…
View article: Flexor Tendon Rupture Secondary to Gout
Flexor Tendon Rupture Secondary to Gout Open
Extra-articular deposition of monosodium urate crystals is a widely recognized manifestation of gout. However, gouty infiltration of flexor tendons in the hand resulting in tendon rupture is exceedingly rare. This case report highlights a …
View article: Novel indications for autologous fat grafting in reconstruction: scleroderma
Novel indications for autologous fat grafting in reconstruction: scleroderma Open
Scleroderma is a chronic connective tissue disease characterized by inflammation, vascular injury, and progressive skin fibrosis, resulting in significant aesthetic and functional impairments for patients. Current therapies are limited and…
View article: Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization
Discoidin domain receptor 2 regulates aberrant mesenchymal lineage cell fate and matrix organization Open
Extracellular matrix (ECM) interactions regulate both the cell transcriptome and proteome, thereby determining cell fate. Traumatic heterotopic ossification (HO) is a disorder characterized by aberrant mesenchymal lineage (MLin) cell diffe…
View article: Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma
Macrophage TGF-β signaling is critical for wound healing with heterotopic ossification after trauma Open
Transforming growth factor–β1 (TGF-β1) plays a central role in normal and aberrant wound healing, but the precise mechanism in the local environment remains elusive. Here, using a mouse model of aberrant wound healing resulting in heteroto…
View article: The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases
The Current State of Fat Grafting in the Hand: A Systematic Review for Hand Diseases Open
Autologous fat grafting (AFG) has traditionally been used for facial rejuvenation and soft tissue augmentation, but in recent years, its use has expanded to treat diseases of the hand. Autologous fat grafting is ideal for use in the hand b…
View article: 2: Genetic- and Mobilization-Based Alterations in Matrix Alignment to Mitigate Aberrant Cell Fate Determination
2: Genetic- and Mobilization-Based Alterations in Matrix Alignment to Mitigate Aberrant Cell Fate Determination Open
Purpose: Cells recognize mechanical cues from the extracellular environment through interactions with matrix proteins, such as collagen. Following injury, fibrotic deposition of collagen can lead to aberrant cell differentiation and failed…
View article: 4: Peripheral Nerves Engage in Reciprocal Neuro- and Angiogenic Crosstalk With SMCs in Extremity Trauma
4: Peripheral Nerves Engage in Reciprocal Neuro- and Angiogenic Crosstalk With SMCs in Extremity Trauma Open
Purpose: Existing literature describes the interdependence between neurotrophic and vascular signals in the central nervous system. We hypothesize a similar crosstalk important to extremity healing involving the peripheral nervous system a…
View article: 4: Prolonged Tourniquet Use Following Blast Related Lower Extremity Injuries Increase Heterotopic Ossification in a Pre-clinical Model
4: Prolonged Tourniquet Use Following Blast Related Lower Extremity Injuries Increase Heterotopic Ossification in a Pre-clinical Model Open
Purpose: Traumatic heterotopic ossification (tHO) has become a signature pathology affecting wounded military personnel who have sustained blast-associated traumatic amputations during the recent conflicts in Iraq and Afghanistan. Heteroto…
View article: QS7: Digit Tip Regeneration Following Amputation Is Not True Regeneration
QS7: Digit Tip Regeneration Following Amputation Is Not True Regeneration Open
Purpose: Repair of distal phalanx amputation is widely studied and thought to occur through a regenerative process. Single-cell RNA sequencing (scRNA) has greatly improved the ability to characterize the cells that are involved in regenera…
View article: High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents
High Frequency Spectral Ultrasound Imaging Detects Early Heterotopic Ossification in Rodents Open
Heterotopic ossification (HO) is a devastating condition in which ectopic bone forms inappropriately in soft tissues following traumatic injuries and orthopedic surgeries as a result of aberrant mesenchymal progenitor cell (MPC) differenti…
View article: Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients
Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients Open
Summary: Systemic scleroderma is a chronic connective tissue disease characterized by internal organ and skin fibrosis. Unfortunately, there is a lack of efficacious treatments for cutaneous manifestations, and alternative interventions sh…
View article: BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma
BMP Ligand Trap ALK3-Fc Attenuates Osteogenesis and Heterotopic Ossification in Blast-Related Lower Extremity Trauma Open
Traumatic heterotopic ossification (tHO) commonly develops in wounded service members who sustain high-energy and blast-related traumatic amputations. Currently, no safe and effective preventive measures have been identified for this patie…
View article: The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury
The role of neutrophil extracellular traps and TLR signaling in skeletal muscle ischemia reperfusion injury Open
Ischemia reperfusion (IR) injury results in devastating skeletal muscle fibrosis. Here, we recapitulate this injury with a mouse model of hindlimb IR injury which leads to skeletal muscle fibrosis. Injury resulted in extensive immune infil…
View article: Medical Education and the Momentum for Virtual Care
Medical Education and the Momentum for Virtual Care Open
Accelerated by social distancing requirements to minimize the spread of coronavirus disease 2019, telemedicine has now become a key mode for delivering clinical care. Telemedicine visits have seen an annual compounded growth of 49% from 20…
View article: Immobilization after injury alters extracellular matrix and stem cell fate
Immobilization after injury alters extracellular matrix and stem cell fate Open
Cells sense the extracellular environment and mechanical stimuli and translate these signals into intracellular responses through mechanotransduction, which alters cell maintenance, proliferation, and differentiation. Here we use a mouse m…
View article: Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal/Stem Cell Therapies
Concise Review: Using Fat to Fight Disease: A Systematic Review of Nonhomologous Adipose-Derived Stromal/Stem Cell Therapies Open
The objective of this Review is to describe the safety and efficacy of adipose stem/stromal cells (ASC) and stromal vascular fraction (SVF) in treating common diseases and the next steps in research that must occur prior to clinical use. P…
View article: Gauze Impregnated With Quaternary Ammonium Salt Reduces Bacterial Colonization of Surgical Drains After Breast Reconstruction
Gauze Impregnated With Quaternary Ammonium Salt Reduces Bacterial Colonization of Surgical Drains After Breast Reconstruction Open
Surgical site infection after breast reconstruction is associated with increased length of hospital stay, readmission rates, cost, morbidity, and mortality. Identifying methods to reduce surgical site infection without the use of antibioti…
View article: Frost Nucleation and Frost Growth on Hydrophobic and Hydrophilic Surfaces for Heat Exchangers Fin Structures
Frost Nucleation and Frost Growth on Hydrophobic and Hydrophilic Surfaces for Heat Exchangers Fin Structures Open
Frost formation decreases the energy efficiency of refrigeration and heat pump systems in building HVAC applications. Several studies exist in the open literature that examined frost formation on fin structures under forced convection cond…