Anna Lorenc
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View article: Pars Plana Vitrectomy Combined with Anti-VEGF Injections as an Approach to Treat Proliferative Diabetic Retinopathy
Pars Plana Vitrectomy Combined with Anti-VEGF Injections as an Approach to Treat Proliferative Diabetic Retinopathy Open
This study aimed to evaluate the impact of preoperative anti-VEGF injections on pars plana vitrectomy (PPV) outcomes in patients with proliferative diabetic retinopathy (PDR). Material and methods: We analysed 232 eyes with proliferative d…
View article: Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes
Physiological and pathogenic T cell autoreactivity converge in type 1 diabetes Open
Autoimmune diseases result from autoantigen-mediated activation of adaptive immunity; intriguingly, autoantigen-specific T cells are also present in healthy donors. An assessment of dynamic changes of this autoreactive repertoire in both h…
View article: <i>NUDCD3</i> deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome
<i>NUDCD3</i> deficiency disrupts V(D)J recombination to cause SCID and Omenn syndrome Open
Inborn errors of T cell development present a pediatric emergency in which timely curative therapy is informed by molecular diagnosis. In 11 affected patients across four consanguineous kindreds, we detected homozygosity for a single delet…
View article: Stickler Syndrome – Case Report and Literature Analysis
Stickler Syndrome – Case Report and Literature Analysis Open
Purpose To present a case of patient with Stickler syndrome and retinal detachment with crystalline lens subluxation. Material and Methods Retrospective case report. Results A 9-years-old patient approached Ophthalmology Department with re…
View article: Topical Insulin in Neurotrophic Keratopathy: A Review of Current Understanding of the Mechanism of Action and Therapeutic Approach
Topical Insulin in Neurotrophic Keratopathy: A Review of Current Understanding of the Mechanism of Action and Therapeutic Approach Open
Neurotrophic keratopathy is a corneal disease characterized by impaired corneal innervation. It can lead to corneal epithelial defects, ulcerations, and perforations. Topical insulin has been shown to be effective in treating this disorder…
View article: Anterior Uveitis and Coats Disease in a 16-Year-Old Girl with Noonan Syndrome—A Case Report
Anterior Uveitis and Coats Disease in a 16-Year-Old Girl with Noonan Syndrome—A Case Report Open
Background: Noonan syndrome (NS) represents a fairly common genetic disorder with a highly variable phenotype. Its features include inherited heart defects, characteristic facial features, short stature, and mild retardation of motor skill…
View article: Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19
Global patterns of antigen receptor repertoire disruption across adaptive immune compartments in COVID-19 Open
Whereas pathogen-specific T and B cells are a primary focus of interest during infectious disease, we have used COVID-19 to ask whether their emergence comes at a cost of broader B cell and T cell repertoire disruption. We applied a genomi…
View article: Immune disease variants modulate gene expression in regulatory CD4+ T cells
Immune disease variants modulate gene expression in regulatory CD4+ T cells Open
We mapped genetic regulation (QTL) of gene expression and chromatin activity in Tregs and we identified 133 colocalizing loci with immune disease variants. For the time being, the preprint DOI: 10.1101/654632
View article: Immune disease variants modulate gene expression in regulatory CD4+ T cells
Immune disease variants modulate gene expression in regulatory CD4+ T cells Open
We mapped genetic regulation (QTL) of gene expression and chromatin activity in Tregs and we identified 133 colocalizing loci with immune disease variants. For the time being, the preprint DOI: 10.1101/654632
View article: Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes Open
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in T regulatory cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tol…
View article: Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes Open
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in T regulatory cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tol…
View article: Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes
Immune and Metabolic Effects of Antigen-Specific Immunotherapy Using Multiple β-Cell Peptides in Type 1 Diabetes Open
Type 1 diabetes is characterized by a loss of tolerance to pancreatic β-cell autoantigens and defects in regulatory T-cell (Treg) function. In preclinical models, immunotherapy with MHC-selective, autoantigenic peptides restores immune tol…
View article: Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects
Mapping T Cell Responses to Native and Neo-Islet Antigen Epitopes in at Risk and Type 1 Diabetes Subjects Open
Aims Recent studies highlight the potentially important role of neoepitopes in breaking immune tolerance in type 1 diabetes. T cell reactivity to these neoepitopes has been reported, but how this response compares quantitatively and phenot…
View article: A Crohn’s Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling
A Crohn’s Disease-associated IL2RA Enhancer Variant Determines the Balance of T Cell Immunity by Regulating Responsiveness to IL-2 Signalling Open
Background and Aims Differential responsiveness to interleukin [IL]-2 between effector CD4+ T cells [Teff] and regulatory T cells [Treg] is a fundamental mechanism of immunoregulation. The single nucleotide polymorphism [SNP] rs61839660, l…
View article: A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis
A consensus Covid-19 immune signature combines immuno-protection with discrete sepsis-like traits associated with poor prognosis Open
Person-to-person transmission of SARS-CoV-2 virus has triggered a global emergency because of its potential to cause life-threatening Covid-19 disease. By comparison to paucisymptomatic virus clearance by most individuals, Covid-19 has bee…
View article: High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation Open
By developing a high-density murine immunophenotyping platform compatible with high-throughput genetic screening, we have established profound contributions of genetics and structure to immune variation. Specifically, high-throughput pheno…
View article: Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'
Response to comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies' Open
In 2016, we reported four substantial observations of APECED/APS1 patients, who are deficient in AIRE, a major regulator of central T cell tolerance (Meyer et al., 2016). Two of those observations have been challenged. Specifically, ‘priva…
View article: TCR repertoire in CD4 T cells of type 1 diabetes patients and healthy donors
TCR repertoire in CD4 T cells of type 1 diabetes patients and healthy donors Open
Deep sequencing of TCR in true naïve (TN), central memory (CM), Treg and Tscm CD4+ T cells of recently diagnosed type 1 diabetes patients (T1D) and healthy donors (HD)
View article: Maternal Diabetes Mellitus – Risk Factor for Fetus and Infant
Maternal Diabetes Mellitus – Risk Factor for Fetus and Infant Open
Diabetes during pregnancy may occur as pregestational or gestational diabetes mellitus.Throughout gestation there is a close relationship between maternal and fetal blood glucose concentrations.Maternal hyperglycemia leads to hyperglycemia…
View article: Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes Open
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells. In contrast, the disease relevance of β cell…