Anna Lorenzin
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View article: #1691 Assessment of oXiris membrane adsorption towards Linezolid: implications for optimizing antibiotic therapy in critically ill patients
#1691 Assessment of oXiris membrane adsorption towards Linezolid: implications for optimizing antibiotic therapy in critically ill patients Open
Background and Aims Sepsis in critically ill patients triggers dysregulated inflammation, leading to organs dysfunction. Antibiotic therapy is crucial in treatment, but faces challenges in optimal delivery due to potential loss in the effl…
View article: #2337 Extracorporeal hemoadsorption therapy in the treatment of sepsis induced by Gram-negative bacteria: <i>in vitro</i> assessment of two new sorbent cartridges
#2337 Extracorporeal hemoadsorption therapy in the treatment of sepsis induced by Gram-negative bacteria: <i>in vitro</i> assessment of two new sorbent cartridges Open
Background and Aims Sepsis is one of the major causes of hospital mortality, characterized by a dysregulated immune response to infection that can lead to multiorgan failure and death. Gram-negative bacteria have emerged as primary contrib…
View article: #1900 Artificial diuresis, a miniaturized device for ultrafiltration: comparison between animal study and mathematical model to assess ultrafiltration
#1900 Artificial diuresis, a miniaturized device for ultrafiltration: comparison between animal study and mathematical model to assess ultrafiltration Open
Background and Aims Fluid overload is associated with adverse outcome both in heart failure patients and critically ill patient admitted to intensive care. Extracorporeal ultrafiltration represents a solution to avoid acute kidney injury d…
View article: #2354 Endotoxin and cytokines removal with new microporous (CA) sorbent prototypes
#2354 Endotoxin and cytokines removal with new microporous (CA) sorbent prototypes Open
Background and Aims Endotoxin, also referred to as lipopolysaccharide (LPS), is a major stimulus of the inflammatory response capable of leading to sepsis and septic shock. Extracorporeal blood purification therapies are increasingly emplo…
View article: Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Haemodiafiltration
Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Haemodiafiltration Open
Background: Removal of large uraemic toxins is still a challenge. Haemodiafiltration (HDF) has produced some results, although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality manage…
View article: Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Hemodiafiltration
Assessment of Safety and Efficacy of Expanded Hemodialysis with Medium Cut-Off Dialyzer Compared to Hemodiafiltration Open
Background: Removal of large uraemic toxins is still a challenge. HDF has produced some results although large convective volume, optimal vascular access to increase the blood flow rate and strict water quality management are required. Med…
#557 Seraph® 100 affinity blood cartridge as a potential adjunctive blood purification strategy for <i>S. aureus</i>-induced septic shock Open
Background and Aims S. aureus infections, particularly methicillin-resistant strains, can induce severe conditions, provoking an overwhelming immune response and contributing to systemic inflammation and organ failure. Effective antibiotic…
#2512 Behaviour of Human Proenkephalin A 119-159 (penKid) in an in vitro model of hemoadsorption Open
Background and Aims Proenkephalin A 119-159 (penKid) is a stable surrogate marker for enkephalins (endogenous opioids regulating kidney function). Different clinical studies have shown severity-dependent increased penKid levels in patients…
#2548 In vitro evaluation of proenkephalin kinetics in hemofiltration and hemodialysis Open
Background and Aims Proenkephalin A 119-159 (penKid) is a stable surrogate marker for enkephalins (endogenous opioids regulating kidney function). PenKid plasma concentration correlates to GFR and increases in AKI, for this reason it can b…
#1416 Extracorporeal removal of per- and polyfluoroalkyl substances (PFAS) by hemoadsorption: in vitro kinetic model Open
Background and Aims Per- and polyfluoroalkyl substances (PFAS) are known water pollutants leading to potential public health consequences. High blood levels of PFAS have been associated with several pathological conditions including testic…
View article: #1351 Assessment of safety and efficacy of expanded hemodialysis in comparison to HDF
#1351 Assessment of safety and efficacy of expanded hemodialysis in comparison to HDF Open
Background and Aims In end-stage kidney disease, solutes with a wide spectrum of molecular weight, called uremic toxins, are retained due to impaired kidney cleansing capacity. Particularly, the retention of toxins in the middle molecular …
#1398 Linezolid adsorption during in vitro model of hemoadsorption with mini-module of HA380 cartridge Open
Background and Aims Septic shock is one of the most frequent causes in Intensive Care Unit (ICU) admission and is related to a very high risk of mortality. About one third of patients with sepsis develops acute kidney injury (AKI) which co…
#2799 Myoglobin removal by hemadsorption: ex-vivo adsorption kinetics Open
Background and Aims Myoglobin, due to its molecular weight of 17 kDa and a Einstein-Stoke radius greater than expected, is classed as a middle molecular weight uremic toxin and presents a two-compartment model of distribution in the body. …
#1983 In vitro iohexol adsorption in cartridges with mesoporous styrene-divinylbenzene sorbent Open
Background and Aims Patients with pre-existing chronic kidney disease (CKD) present the highest risk of developing contrast-associated acute kidney injury (CA-AKI). Iodinated contrast agents such as iohexol (molecular weight 821 Da) don't …
View article: Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup
Hemoadsorption: consensus report of the 30th Acute Disease Quality Initiative workgroup Open
Adsorption-based extracorporeal therapies have been subject to technical developments and clinical application for close to five decades. More recently, new technological developments in membrane and sorbent manipulation have made it possi…
View article: Hemoadsorption Combined with Hemodialysis and the “Inflammation Mitigation Hypothesis”
Hemoadsorption Combined with Hemodialysis and the “Inflammation Mitigation Hypothesis” Open
Clinical outcomes are still unsatisfactory in patients undergoing chronic maintenance dialysis. Signs and symptoms of uremic intoxication are often present even in presence of an adequate dialysis delivery. These along with cardiovascular …
Adsorption Mass Transfer Zone of Vancomycin in Cartridges With Styrene-Divinylbenzene Sorbent Open
Cartridges for hemoadsorption containing styrene-divinylbenzene sorbent are used for multiple conditions, such as intoxication. The mass transfer zone comprises the extension along the longitudinal span of the cartridge where adsorption oc…
View article: Standardization of Nomenclature for the Mechanisms and Materials Utilized for Extracorporeal Blood Purification
Standardization of Nomenclature for the Mechanisms and Materials Utilized for Extracorporeal Blood Purification Open
In order to develop a standardized nomenclature for the mechanisms and materials utilized during extracorporeal blood purification, a consensus expert conference was convened in November 2022. Standardized nomenclature serves as a common l…
New Miniaturized System for Ultrafiltration: Rationale and Design of a Single-Center, Crossover, Randomized, Open-Label, Pilot Study Protocol Open
Introduction: Fluid overload and congestion are common features in patients with heart failure and are associated with negative clinical outcomes. Therapies for these conditions are diuretic-centered but frequently fail to achieve patient-…
View article: Artificial Diuresis: Animal Studies on Efficacy and Safety of a New Miniaturized Device for Extracorporeal Ultrafiltration
Artificial Diuresis: Animal Studies on Efficacy and Safety of a New Miniaturized Device for Extracorporeal Ultrafiltration Open
Introduction: We have recently developed a new miniaturized device for extracorporeal ultrafiltration (UF) to be used in patients with fluid overload: Artificial Diuresis-1 (AD1) (Medica S.p.A., Medolla, Italy). The device has a reduced pr…
Vancomycin Adsorption during in vitro Model of Hemoperfusion with Mini-Module of HA380 Cartridge Open
Introduction: Sepsis is a frequent complication in critically ill patients. Patients may require control of the source of infection, removal of pathogens and damaged cells, and organ support. Often, these targets can be achieved through th…
MO274: Vancomycin Adsorption During <i>In Vitro</i> Model of Hemoperfusion with Mini-Module of HA380 Cartridge Open
BACKGROUND AND AIMS Septic shock is one of the most frequent causes in Intensive Care Unit (ICU) admission and is related to a very high risk of mortality. About one-third of patients with sepsis develops AKI which contributes to a worseni…
Supplementary Material for: Clinical Assessment of Continuous Hemodialysis with the Medium Cutoff EMiC<b>®</b>2 Membrane in Patients with Septic Shock Open
Introduction: At the time of renal replacement therapy, approximately 20% of critically ill patients have septic shock. In this study, medium cutoff (MCO) continuous venovenous hemodialysis (CVVHD) was compared to high-flux membrane contin…
PMMA-Based Continuous Hemofiltration Modulated Complement Activation and Renal Dysfunction in LPS-Induced Acute Kidney Injury Open
Sepsis-induced acute kidney injury (AKI) is a frequent complication in critically ill patients, refractory to conventional treatments. Aberrant activation of innate immune system may affect organ damage with poor prognosis for septic patie…
Vancomycin Adsorption During in vitro Model of Hemoperfusion with HA380 Cartridge Open
Introduction: A critical point for using blood purification during sepsis may be the potential interaction with antimicrobial therapy, the mainstay of sepsis treatment. The aim of our study was to investigate the vancomycin removal during …
P0531CONTINUOUS HEMODIAFILTRATION WITH PMMA HEMOFILTER MODULATED COMPLEMENT ACTIVATION AND RENAL DYSFUNCTION IN A SWINE MODEL OF SEPSIS-INDUCED ACUTE KIDNEY INJURY Open
Background and Aims Sepsis-induced acute kidney injury (AKI) is a growing health care problem, refractory to conventional treatments. This disease is characterized by an overwhelmed immune response against a primary insult that become resp…
P0540EFFECT OF MEMBRANE MATERIALS ON VANCOMYCIN, TEICOPLANIN AND LINEZOLID REMOVAL DURING CONTINUOUS RENAL REPLACEMENT THERAPIES: AN IN VITRO STUDY Open
Background and Aims In a continuous renal replacement therapy (CRRT) scenario, removal of anti-methicillin resistant Staphylococcus Aureus agents can be quantitatively important, thereby contributing to clinically relevant decreases in the…
P0554IN VITRO ASSESSMENT OF HA330 CARTRIDGE ADSORPTION CAPACITY REALTED TO VANCOMYCIN Open
Background and Aims The rationale for blood purification as adjunctive therapy during sepsis involved the capacity in removing endogenous and exogenous toxins, but currently no recommendations exists [1]. A critical point may be the potent…