Anna M. Dahlin
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View article: P12.07.B RARE GERMLINE VARIANTS CONTRIBUTE TO GLIOMA PREDISPOSITION
P12.07.B RARE GERMLINE VARIANTS CONTRIBUTE TO GLIOMA PREDISPOSITION Open
BACKGROUND Gliomas are the most common malignant primary brain tumors in adults and are associated with high mortality, particularly at higher grades. While familial syndromes and common genetic risk factors are relevant in glioma suscepti…
View article: The impact of socioeconomic status on glioma survival: a retrospective analysis
The impact of socioeconomic status on glioma survival: a retrospective analysis Open
Purpose Although sociodemographic factors such as socioeconomic status (SES), travel time to health care, cohabitation status, and region of residence are observed to influence incidence and survival for several types of cancers, it is unc…
View article: OS03.5.A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF 4,069 CHILDREN WITH GLIOMA IDENTIFIES 9P21.3 RISK LOCUS
OS03.5.A MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY OF 4,069 CHILDREN WITH GLIOMA IDENTIFIES 9P21.3 RISK LOCUS Open
BACKGROUND While recent sequencing studies have revealed that 10% of childhood gliomas are caused by rare germline mutations, the role of common variants is undetermined and no genome-wide significant risk loci for pediatric CNS tumors hav…
View article: P21.02.B THE EFFECT OF SOCIODEMOGRAPHIC FACTORS ON GLIOMA PROGNOSIS
P21.02.B THE EFFECT OF SOCIODEMOGRAPHIC FACTORS ON GLIOMA PROGNOSIS Open
BACKGROUND Sociodemographic factors are well known to contribute to health disparities for different cancer diagnoses, but they are not extensively studied for glioma patients. In this study socioeconomic status (SES), travel time to healt…
View article: Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines
Low-grade glioma risk SNP rs11706832 is associated with type I interferon response pathway genes in cell lines Open
View article: Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status Open
Purpose: The aim of this study was to relate the CpG island methylator phenotype (CIMP; characterized by extensive promoter hypermethylation) to cancer-specific survival in colorectal cancer, taking into consideration relevant clini…
View article: Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Supplementary Tables 1-7 Supplementary Table 1. PCR primers and conditions Supplementary Table 2. List of included diagnoses in each histological subgroup Supplementary Table 3. Associations between published genetic risk variants and risk…
View article: Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Supplementary Tables 1-7 from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Supplementary Tables 1-7 Supplementary Table 1. PCR primers and conditions Supplementary Table 2. List of included diagnoses in each histological subgroup Supplementary Table 3. Associations between published genetic risk variants and risk…
View article: Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status Open
Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
View article: Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Background: Although glioma etiology is poorly understood in general, growing evidence indicates a genetic component. Four large genome-wide association studies (GWAS) have linked common genetic variants with an increased glioma ris…
View article: Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status Open
Supplementary Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
View article: Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status
Data from The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status Open
Purpose: The aim of this study was to relate the CpG island methylator phenotype (CIMP; characterized by extensive promoter hypermethylation) to cancer-specific survival in colorectal cancer, taking into consideration relevant clini…
View article: Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study
Data from Investigation of Established Genetic Risk Variants for Glioma in Prediagnostic Samples from a Population-Based Nested Case–Control Study Open
Background: Although glioma etiology is poorly understood in general, growing evidence indicates a genetic component. Four large genome-wide association studies (GWAS) have linked common genetic variants with an increased glioma ris…
View article: Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus
Multi-ancestry genome-wide association study of 4069 children with glioma identifies 9p21.3 risk locus Open
Background Although recent sequencing studies have revealed that 10% of childhood gliomas are caused by rare germline mutations, the role of common variants is undetermined and no genome-wide significant risk loci for pediatric central ner…
View article: Prediagnostic biomarkers for early detection of glioma—using case–control studies from cohorts as study approach
Prediagnostic biomarkers for early detection of glioma—using case–control studies from cohorts as study approach Open
Background Understanding the trajectory and development of disease is important and the knowledge can be used to find novel targets for therapy and new diagnostic tools for early diagnosis. Methods Large cohorts from different parts of the…
View article: P10.18.A Replication of previous GWAS identifies TERT and near EGFR SNVs as risk factors in EPIC glioma patients: a nested case-control study
P10.18.A Replication of previous GWAS identifies TERT and near EGFR SNVs as risk factors in EPIC glioma patients: a nested case-control study Open
Background Gliomas, the most common malignant primary brain tumors in adults, typically have a poor prognosis irrespective of medical care. Previous large genome-wide association studies (GWAS) have identified 27 single-nucleotide variants…
View article: Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples Open
No strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre‐di…
View article: Pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα, and sIL-6R are associated with glioma risk: a nested case-control study of repeated samples
Pre-diagnostic levels of sVEGFR2, sTNFR2, sIL-2Rα, and sIL-6R are associated with glioma risk: a nested case-control study of repeated samples Open
View article: Swedish substrates suited for circular production of the edible gourmet mushroom maitake
Swedish substrates suited for circular production of the edible gourmet mushroom maitake Open
A selection of locally sourced substrates were evaluated for hyphal growth and fruiting body production of the edible gourmet mushroom maitake (Grifola frondosa). Hyphal growth was evaluated on a wide range of substrates (30) including dif…
View article: A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences Open
The number of national reference populations that are whole-genome sequenced are rapidly increasing. Partly driving this development is the fact that genetic disease studies benefit from knowing the genetic variation typical for the geogra…
View article: Travel time to care does not affect survival for patients with colorectal cancer in northern Sweden: A data linkage study from the Risk North database
Travel time to care does not affect survival for patients with colorectal cancer in northern Sweden: A data linkage study from the Risk North database Open
In contrast to most other studies, no association between travel time and colorectal cancer survival was found; despite that longer travel time was associated with known risk factors for poorer outcome. In the Swedish health care setting, …
View article: A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences
A whole-genome sequenced control population in northern Sweden reveals subregional genetic differences Open
The number of national reference populations that are whole-genome sequenced are rapidly increasing. Partly driving this development is the fact that genetic disease studies benefit from knowing the genetic variation typical for the geogra…
View article: A genome-wide association study on medulloblastoma
A genome-wide association study on medulloblastoma Open
Introduction Medulloblastoma is a malignant embryonal tumor of the cerebellum that occurs predominantly in children. To find germline genetic variants associated with medulloblastoma risk, we conducted a genome-wide association study (GWAS…
View article: The Genetic Architecture of Gliomagenesis–Genetic Risk Variants Linked to Specific Molecular Subtypes
The Genetic Architecture of Gliomagenesis–Genetic Risk Variants Linked to Specific Molecular Subtypes Open
Genome-wide association studies have identified 25 germline genetic loci that increase the risk of glioma. The somatic tumor molecular alterations, including IDH-mutation status and 1p/19q co-deletion, have been included into the WHO 2016 …
View article: Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study
Role of monoamine-oxidase-A-gene variation in the development of glioblastoma in males: a case control study Open
Background The Mono-amine oxidase-A (MAO-A) enzyme is involved in the degradation and regulation of catecholamines such as serotonin, dopamine, epinephrine and nor-epinephrine. Preclinical studies suggest that this enzyme may contribute to…
View article: The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking
The association between longer relative leukocyte telomere length and risk of glioma is independent of the potentially confounding factors allergy, BMI, and smoking Open
View article: P04.40 Telomere maintenance and glioma predisposition - relevance of telomere genetic score and telomere length
P04.40 Telomere maintenance and glioma predisposition - relevance of telomere genetic score and telomere length Open
Germline variants associated with predisposition for cancer are frequently located in genes involved in genome integrity. The telomeres at the chromosome ends are important in maintaining genomic stability, and germline variants in telomer…
View article: P01.03 Telomere length, allergies and risk of glioma
P01.03 Telomere length, allergies and risk of glioma Open
\nBackground: In glioma, a malignant brain tumour with poor prognosis, the etiology is largely unkown. Rare inherited syndromes, and high doses of ionising radiation are associated with increased risk of glioma. Common genetic variants hav…
View article: EPID-13. POLYMORPHISMS IN MYELOID-ASSOCIATED GENES PREDICT GLIOMA SURVIVAL
EPID-13. POLYMORPHISMS IN MYELOID-ASSOCIATED GENES PREDICT GLIOMA SURVIVAL Open
Growing evidence is revealing an association between the myeloid cell infiltration and glioma development and progression. Therefore, identifying myeloid-derived genes variants that predict survival may demonstrate important insight into t…
View article: Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor
Relation between Established Glioma Risk Variants and DNA Methylation in the Tumor Open
Genome-wide association studies and candidate gene studies have identified several genetic variants that increase glioma risk. The majority of these variants are non-coding and the mechanisms behind the increased risk in carriers are not k…